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Rare Aggressive form of Multiple Myeloma with Diffuse Osteosclerosis and Elevated Ca 15-3 Levels


Affiliations
1 Department of Hematology, Ziv Medical Center, Zefat, Israel
2 Ziv Medical Center, Zefat, Israel
3 Bar-Ilan University, Safed, Israel
4 Clalit Health Service, Akko, Israel
 

We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.

Keywords

Multiple Myeloma, Osteosclerosis, CA 15-3, Pleural Effusion.
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  • Rare Aggressive form of Multiple Myeloma with Diffuse Osteosclerosis and Elevated Ca 15-3 Levels

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Authors

Dally Najib
Department of Hematology, Ziv Medical Center, Zefat, Israel
Daniel Talmud
Ziv Medical Center, Zefat, Israel
Saher Srour
Bar-Ilan University, Safed, Israel
Rola Khamisy-Farah
Clalit Health Service, Akko, Israel
Raymond Farah
Department of Hematology, Ziv Medical Center, Zefat, Israel

Abstract


We report the case of a 56-year-old female who had recently been examined for back and epigastric pain, and was diagnosed in the internal medicine ward as having an aggressive rare form of multiple myeloma with diffuse osteoblastic bone lesions. She also had high levels of breast tumor marker (CA 15-3), severe tumor lysis syndrome, and pleural and central nervous system involvement. A few cases of multiple myeloma with diffuse osteosclerosis that are not part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changeshave) have been described. None of these cases were as aggressive as our case. To our knowledge it is the first report describing an elevation in CA 15-3 in conjunction with multiple myeloma.

Keywords


Multiple Myeloma, Osteosclerosis, CA 15-3, Pleural Effusion.