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Kaur, Amrinder
- Hyperbasophilic Variant of Acute Promyelocytic Leukemia
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MVP Journal of Medical Sciences, Vol 3, No 2 (2016), Pagination: 125-127Abstract
Acute Promyelocytic Leukemia (APL) is an extremely rare variant of acute myeloid leukemia. APL constitutes around 10-15 % of acute myeloid leukemia in adults. It is commonly diagnosed around 40 years age. Molecular/genetic studies exhibit chromosomal translocation between chromosome 15 and chromosome 17-t(15;17)(q22;q21) and PML-RARa rearrangement. Four variants of APL have been identified: The classic form M3 hypergranular variant, the microgranular variant, the hyperbasophilic form and zinc-finger form-M3r, identified by a different chromosomal translocation, between chromosome 11 and chromosome 17:t(11,17) (q23, q11-12).Keywords
Acute Promyelocytic Leukemia, ATRA, PML/RARαReferences
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