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Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple Sclerosis


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1 Karadeniz Technical University, 61080 Trabzon, Turkey
 

Multiple sclerosis (MS) has been associated with reduced bone mineral density (BMD).The purpose of this study was to determine the possible factors affectingBMDin patients withMS.We included consecutive 155 patients withMS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lower T-scores and Z-scores in the femoral neck and trochanter compared to the controls. Ninety-four (61%) patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 (41.3%) had osteopenia and 30 (19.4%) had osteoporosis. The main factors affecting BMD were disability, duration of MS, and smoking. There was a negative relationship between femoral BMD and EDSS and disease duration. No association with lumbar BMD was determined.There were no correlations between BMD at any anatomic region and cumulative corticosteroid dose. BMD is significantly lower in patients with MS than in healthy controls. Reduced BMD in MS is mainly associated with disability and duration of the disease. Short courses of high dose steroid therapy did not result in an obvious negative impact on BMD in the lumbar spine and femoral neck in patients with MS.
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  • Lack of Association between Pulse Steroid Therapy and Bone Mineral Density in Patients with Multiple Sclerosis

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Authors

Serap Zengin Karahan
Karadeniz Technical University, 61080 Trabzon, Turkey
Cavit Boz
Karadeniz Technical University, 61080 Trabzon, Turkey
Sevgi Kilic
Karadeniz Technical University, 61080 Trabzon, Turkey
Nuray Can Usta
Karadeniz Technical University, 61080 Trabzon, Turkey
Mehmet Ozmenoglu
Karadeniz Technical University, 61080 Trabzon, Turkey
Vildan Altunayoglu Cakmak
Karadeniz Technical University, 61080 Trabzon, Turkey
Sibel Gazioglu
Karadeniz Technical University, 61080 Trabzon, Turkey

Abstract


Multiple sclerosis (MS) has been associated with reduced bone mineral density (BMD).The purpose of this study was to determine the possible factors affectingBMDin patients withMS.We included consecutive 155 patients withMS and 90 age- and sex-matched control subjects. Patients with MS exhibited significantly lower T-scores and Z-scores in the femoral neck and trochanter compared to the controls. Ninety-four (61%) patients had reduced bone mass in either the lumbar spine or the femoral neck; of these, 64 (41.3%) had osteopenia and 30 (19.4%) had osteoporosis. The main factors affecting BMD were disability, duration of MS, and smoking. There was a negative relationship between femoral BMD and EDSS and disease duration. No association with lumbar BMD was determined.There were no correlations between BMD at any anatomic region and cumulative corticosteroid dose. BMD is significantly lower in patients with MS than in healthy controls. Reduced BMD in MS is mainly associated with disability and duration of the disease. Short courses of high dose steroid therapy did not result in an obvious negative impact on BMD in the lumbar spine and femoral neck in patients with MS.