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Thyroid Hormones as Renal Cell Cancer Regulators


Affiliations
1 Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
2 Institute of Genetics and Biotechnology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland
 

It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors. Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma.
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  • Thyroid Hormones as Renal Cell Cancer Regulators

Abstract Views: 49  |  PDF Views: 1

Authors

Lukasz Szymanski
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
Damian Matak
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
Ewa Bartnik
Institute of Genetics and Biotechnology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland
Cezary Szczylik
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
Anna M. Czarnecka
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland

Abstract


It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors. Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma.