A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Agarwal, A.
- Phytochemical Evaluation of Extracts of Stem of Eclipta alba (Bhringaraja)
Authors
1 Department of Chemistry, College of Pharmacy, IFTM, Moradabad, (U.P.), IN
2 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, (Rajasthan), 302025, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 134-139Abstract
This paper deals with the detailed phytochemical evaluation of the stem of Eclipta alba (Bhringaraja) family: (Compositae). The preliminary phytochemical screening shows that different extracts of plant have different constituents like carbohydrate, alkaloids, phenolics, steroids, glycosides, fat and oils. TLC of the hexane extract after column extraction was shown Rf value 0.78 in Petroleum ether:Hexane:Chloroform:Methanol, used as mobile phase in 2:4:2:1 ratio and TLC of pet. Ether extract also shown Rf value is 0.72 in Petroleum ether:Hexane:Chloroform, used as mobile phase in 4:3:1 ratio after column extraction. This is evaluated by the instrumental analysis (UV, IR, and NMR) of hexane and pet. Ether extract. They shows consequently that pet. Ether extract contains alkane (2940 Cm-1, δ 0.827), alkene (1630 Cm-1, δ 1.253-1.351), monomer of aliphatic acid (1760 Cm-1 δ 2.169), aromatic amine (1570 Cm-1, δ 2.593) etc. and hexane extract contains alkane (2940 cm-1, δ 0.801-0.873) alkene (1625 Cm-1, δ 0.988-1.075) aldehyde (1740 Cm-1, δ 2.154 – 2.288) and aromatic alcohol (1110Cm-1, δ 5.324). These data suggests that the extracts (pet. ether and hexane) may have the glycoside, aliphatic acid, steroids, fats and oils. They are pharmacologically important.Keywords
Eclipta alba, Flavanoids, Glycosides, Thin Layer Chromatography.References
- Kritikar KR and Basu BD. Chronica Botanica Indian Medicinal plants. New Delhi. 1975
- Chopra RN et al. Glossary of medicinal plants. CSIR publication, New Delhi. 1966: pp.104.
- Evans WC. Trees and Evans pharmacognosy. W.B. Saunders , London. 2002; 15th ed: pp. 4-8.
- Sharma PC et al. Database of meditional plants used in ayurveda. Vol II. Central council for research in ayurveda and siddha, New Delhi. 2001; 15th ed: pp. 590.
- Wagner H et al. Coumestans as the Main Active Principles of the Liver Drugs Eclipta alba and Wedelia calendulacea. Plant Med. 1986; 5: 370-374.
- Yahara S and Ning D. Taraxastane glycosides from Eclipta alba. Phyto Chem.1997; 44 (1): 131-135.
- Upahyay RK et al. Eclalbatin, a triterpene saponin from Eclipta alba. J Asian Nat Prod Res. 2001; 3(3): 213-217.
- Leal LKAM et al. Antinociceptive, Anti-inflammatory and bronchodilator activities of Brazilian medicinal plant containing coumarin: a comparative study. J Ethnopharmacol. 2000; 70: 151-159.
- Kokate CK. Practical pharmacognosy. Vallabh Prakashan, Delhi. 1986b; 1th ed: pp. 111.
- Harborne JB. Methods of Extraction and isolation. In: Phytochemical methods. Chapman and hall, London. 1998; 3rd ed: pp. 60-66.
- Agarwal OP. Advanced practical organic chemistry. Goel publishing house, Meerut. 2000; pp. 43, 59.
- Kothavade RJ et al. Protective effect on an Indigenous drug Livomyn on Ketoconazole Induced hepatotoxicity. Indian J Pharm Sci. 1996; 58(4): 142-146.
- Singh B et al. In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol. 2001; 45(4): 435-441.
- Zhang X et al. Screening of antiviral agents from medicinal herbs by means of Hepadnaviruses models. Zhonggno Zhong Yao Za Zi. 1996; 21(8): 480-1, 510.
- Kumar S et al. Antibacterial activity observed in the seeds of some Coprophilous plants. Indian J Pharm. 1997; 35(3): 179-184.
- Thakur VD and Mengi SA. Neuropharmacological profile of Eclipta alba (Linn.) Hassk. J Ethnopharmacol. 2005; 102(1): 23-31.
- Sawant M et al. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytother Res. 2004; 18(2): 111-113.
- Ananthi J et al. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med. 2003; 76(3): 97-102.
- Khandeparkar UK and Kulkarni RD. Antifatigue effect of indigenous drug 'Geriforte' in rats. Indian Drugs. 1981; 18(10): 346-349.
- George M et al. A search for Antibiotic substance in some Indian medicinal plants. J Sci Indian Res. 1947; B: 42-46.
- Kishore N and Dubey NK. Fungitoxicity of some higher plant against Trichophyton rubrum and Epidermophyton floccossum. Indian J Pharm Sci. 1988; 50 (60): 323-325.
- Venaktsam S and Ravi R. Antifungal Activity of Eclipta alba. Indian J Pharm Sci. 2004; Jan- feb: 97-98.
- Roy RK et al. Development and evaluation of polyherbal formulation for hair growth-promoting activity. J Cosmet Dermatol. 2007; 6(2): 108-112.
- Rangineni V et al. Diuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot study. J Med Food. 2007; 10(1): 143-148.
- Christybapita D et al. Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus. Fish Shellfish Immunol. 2007; 23(4): 840-52.
- Jayathirtha MG and Mishra SH. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine. 2007; 11(4): 361-365.
- Pharmacoeconomics - Emerging Need of Health System
Authors
1 Dept. of Community Medicine, G. R. Medical College, Gwalior 474009 (MP), IN
2 Dept. of Pharmacology, G. R. Medical College, Gwalior 474009 (MP), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 166-170Abstract
No Abstract.References
- T. Walley and A. Haycox. Pharmacoeconomics: basic concepts and terminology. Br J Clin Pharmacol 1997; 43: 343-348.
- Cull R, Wells N, Miocevick M Economic costs of migraine Br J Med Econ 1992; 5:103-115.
- http;//cdsco.nic.in/html/cdsco%contact20125-9-08.hhn, access on 6/8/2013.
- McGregor M Cost-utility analysis: use QALYs only with great caution. Can Med Ass J 2003; 168:433-434.
- Raftery J. NICE: faster access to modern treatments? Analysis of guidance on health technologies. Br Med J 2001; 323:1300-1303.
- A Clinical Study on Role of Different Types of Plates in Surgical Management of Middle one Third Clavicle Fracture in Adults
Authors
1 SS Medical College Rewa, MP, IN
Source
International Journal of Medical and Dental Sciences, Vol 5, No 1 (2016), Pagination: 991-995Abstract
Background:Fractures of the clavicle is one of the most common injures of human skeleton. It has been traditionally treated nonoperatively.Objectives: The present study was undertaken to evaluate the outcome of different types of plates in surgical management of middle one third clavicle fracture in adults.
Methods: Thirty two adult patients with middle one third clavicular fractures treated surgically between July2011 to May 2013 were included for this study. 22 middle third clavicle fractures were fixed with reconstruction plate and screws and six middle third clavicle fractures were fixed with semitubular plate and screws and 4 middle third clavicle fractures were fixed with dynamic compression plate and screws. The functional outcome compared.
Result: Among 32 patients with middle third clavicle fracture treated with plate and screws 30 fractures united at an average of 11.13 weeks.
Conclusion: Clavicle fractures are usually treated conservatively but there are specific indications for which operative treatment is needed like comminuted, displaced middle third clavicle fractures. In this study reconstruction plates were used as it can be contoured to the shape of the clavicle. Semitubular plates were used in 6 patients and it had no complications but it was difficult to contour. Dynamic compression plate is strong but it gives excessive prominence through the skin and it is difficult to contour.
Keywords
Clavicle, Fracture, Non-Union, Plates, Union.- Ocular Surface Disorders in Patients Admitted in Intensive Care Unit of a Tertiary Care Hospital
Authors
1 Department of Ophthalmology, SRMS IMS, Bareilly, IN
Source
Invertis Journals of Science & Technology, Vol 10, No 2 (2017), Pagination: 93-97Abstract
To assess the frequency and to identify the predisposing factors for ocular surface disorders in ICU patients. Prospective observational study of all patients admitted to the ICU complex of SRMSIMS between1st January to 31st April 2016 for a minimum period of 5 days. Patients will be observed for abnormalities of the lid , conjunctiva, cornea and tear film by diffuse illumination aided by Schirmer's Test, corneal and conjunctival staining and conjunctival swab when required. Other factors like consciousness, use of a ventilator, preexisting comorbidities shall also be noted. Patients will be observed on Day1, 5, 6, and so on. 60 eyes of 30 patients were examined . In mechanically ventilated patients , 36 eyes (60%) had conjunctival hyperemia which resolved upon intervention which included antibiotics and lubricants . 18 eyes (9%) had conjunctival discharge which resolved upon intervention. 12 eyes (20%) were stain positive. The critically ill often develop ocular surface disorders, especially when sedated and immobilized. A close relationship was observed between these conditions and the inability to close one's eyes. The presence of ocular surface disease was closely correlated with the degree of lagophthalmos, which in turn was closely related to the depth of sedation or paralysis.Keywords
Ocular Surface Disorders, ICU, Intensive Care Unit.References
- A. Grixti, M. Sadri, J. Edgar and A.V. Datta. Ocular surface disorders in patients in intensive care units. The Ocular Surface. 10, (2012) 26-42.
- N. Joyce. A Systematic Review. 21. Adelaide, Australia: The Joanna Briggs Institute for Evidence Based Nursing and Midwifery; Eye care for the intensive care patient. (2002).
- E.K. Mela, E.G. Drimtzias, M.K. Christofidou, K.S. Filos, E.D. Anastassiou and S.P. Gartaganis. Ocular surface bacterial colonisation in sedated intensive care unit patients. Anaesthesia and Intensive Care. 38(1), (2010) 190-193.
- J.F. Kirwan, T. Potamitis, H. El-Kasaby, M.W. Hope-Ross and G.A. Sutton. Lesson of the week: microbial keratitis in intensive care. British Medical Journal. 314(7078), (1997) 433-434.
- E.V. Hernandez and M.J. Mannis. Superficial keratopathy in intensive care unit patients. American Journal of Ophthalmology. 124(2), (1997) 212-216.
- H. Imanaka, N. Taenaka, J. Nakamura, K. Aoyama and H. Hosotani. Ocular surface disorders in the critically ill. Anesthesia and Analgesia. 85(2), (1997) 343-347.
- F. Mercieca, P. Suresh, A. Morton and A. Tullo. Ocular surface disease in intensive care unit patients. Eye. 13(2), (1999) 231-236.
- P. Suresh, F. Mercieca, A. Morton and A. Tullo. Eye care for the critically ill. Intensive Care Med. 26, (2000) 162-166.
- J.F. Kirwan, T. Potamitis, H. El-Kasaby, M.W. Hope-Ross and G.A. Sutton. Microbial keratitis in intensive care. BMJ. 314, (1997) 433-434.
- J. Wincek and M.S. Ruttum. Exposure keratitis in comatose children. J Neurosci Nurs. 21, (1989) 241-244.
- D.C.J.J. Bergmans, M.J.M. Bonten, F.H. Van Tiel, C.A. Gaillard, S. van der Geest and R.M. Wilting et al. Cross-colonisation with Pseudomonas aeruginosa of patients in an intensive care unit. Thorax. 53, (1998) 1053-1058.
- X. Bertrand, M. Thouverez, D. Talon, A. Boillot, G. Capellier and C. Floriot et al. Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units. Intensive Care Med. 27, (2001) 1263-1268.
- T.B. Saritas, B. Bozkurt, B. Simsek, Z. Cakmak, M. Ozdemir and A. Yosunkaya. Ocular Surface Disorders in Intensive Care Unit Patients. The Scientific World Journal (2013) 182038. http://doi.org/10.1155/2013/182038.
- B. Parkin and S. Cook. A clear view: The way forward for eye care on ICU. Intensive Care Med. 26, (2000) 155-6.
- S.B. Lenart and J.A. Garrity. Eye care for patients receiving neuromuscular blocking agents or propofol during mechanical ventilation. Am J Crit Care. 9, (2000) 188-91.
- Necessity of ‘Two Time Zones: IST-I (UTC + 5 : 30 h) and IST-II (UTC + 6 : 30 h)’ in India and Its Implementation
Authors
1 Academy of Scientific and Innovative Research (AcSIR), CSIR-NPL Campus, New Delhi 110 012, IN
2 CSIR-National Physical Laboratory (CSIR-NPL), Dr K. S. Krishnan Marg, New Delhi 110 012,, IN
Source
Current Science, Vol 115, No 7 (2018), Pagination: 1252-1261Abstract
A strong demand of a separate time zone by northeast populace has been a matter of great debate for a very long period. However, no implementable solution to this genuine problem has yet been proposed. The CSIR-National Physical Laboratory, CSIR-NPL (the National Measurement Institute, NMI, o f India and custodian o f Indian Standard Time, IST) proposes an implementable solution that puts the country in two time zones: (i) IST-I (UTC + 5: 30 h, represented by longitude passing through 82 °33 E) covering the regions falling between longitude 68 °7 E and 89 °52 E and (ii) IST-II (UTC + 6: 30 h, represented by longitude passing through 97°30E) encompassing the regions between 89°52E and 97°25E. The proposed demarcation line between IST-I and IST-II, falling at longitude 89 °52 E, is derived from analyses o f synchronizing the circadian clocks to normal office hours (9: 00 a.m. to 5 : 30p.m.). This demarcation line passes through the border of West Bengal and Assam and has a narrow spatial extension, which makes it easier to implement from the railways point o f view. Once approved, the implementation would require establishment of a laboratory for ‘Primary Time Ensemble - I I ’ generating IST-II in any o f the north-eastern states, which would be equivalent to the existing ‘Primary Time Ensemble-I’ at CSIR-NPL, New Delhi.Keywords
Circadian Clock, Energy Saving, Indian Standard Time, Longitude, Sun Graphs, Two Time Zone.References
- Liang, L., One India, two time zones. The Hindu, 2017; retrieved from http://www.thehindu.com/opinion/op-ed/one-india-two-timezones/article17653169.ece
- Wikimedia Commons, Standard time zones of the world. Retrieved from https://commons.wikimedia.org/wiki/File:Standard time zones of the world (2012).svg
- Bureau International des PoidsetMesures (BIPM), Coordinate Universal Time, UTC, retrieved from https://www.bipm.org/cc/CCTF/Allowed/18/CCTF 09-32 noteUTC.pdf
- Bureau International des Poidset Mesures (BIPM), SI Brochure: The International System of Units (SI), Unit of time (second), retrieved from https://www.bipm.org/en/publications/si-brochure/ second.html
- International Earth Rotation Service (IERS), retrieved from https://www.iers.org/IERS/EN/Home/home_node.html
- Bureau International des Poidset Mesures (BIPM), Member States and Associates of the Metre Convention, retrieved from www.bipm.org/en/convention/member_states/
- Time and date. com, Time Zones in the United States. Retrieved from https://www.timeanddate.com/time/zone/usa
- National Institute of Standard and Technology, Time and Frequency Services; https://www.nist.gov/pml/time-and-frequency-division/time-services
- United States Naval Oceanography, precise time, retrieved from http://www.usno.navy.mil/USNO/time
- CSIR-National Physical Laboratory, National Measurement Institute of India, Time and Frequency Metrology, retrieved from http://www.nplindia.in/time-and-frequency-metrology-section
- CSIR-National Physical Laboratory, National Measurement Institute of India, CSIR-NPL and ISRO sign MoU for time and frequency traceability services, retrieved from http://www.nplindia.in/csir-npl-and-isro-sign-mou-time-and-frequency-traceability-services.
- Ahuja, D. R., Sen Gupta, D. P. and Agrawal, V. K., Energy savings from advancing the Indian Standard Time by half an hour. Curr. Sci., 2007, 93, 298-302.
- Nobelprize.org; The Nobel Prize in Physiology or Medicine 2017; retrieved from https://www.nobelprize.org/nobel prizes/medicine/laureates /2017/press. html
- Wikimedia Commons, Overview of biological circadian clock in humans, retrieved from https://commons.wikimedia.org/wiki/File%3ABiological_clock_human.svg
- Wikipedia, Seasons and some Earth's orbit characteristics. retrieved from https://en.wikipedia.org/wiki/Earth%27s orbit#/media/File:Seasons1.svg
- Time and date. com, Sunrise and Sunset Calculator, retrieved from https://www.timeanddate.com/sun
- Wikipedia, List of states and union territories of India by population, retrieved from https://en.wikipedia.org/wiki/List_of_states_and_union_territories_of_India_by_population
- Central Electricity Authority, Growth of Electricity Sector in India from 1947-2017, Ministry of Power, Government of India, 2017, retrieved from http://www.cea.nic.in/reports/others/planning/pdm/growth 2017.pdf
- Wikipedia, Map of Northeast Frontier Railway zone railway lines. Retrieved from https://en.wikipedia.org/wiki/Northeast_Frontier_Railway_zone#/media/File:Northeast_India_railway.png
- Planning Commission, Government of India, Annual report of planning commission on the ‘working of state power utilities and electricity departments’, 2014; retrieved from http://planningcommission.gov.in/reports/genrep/reparpower1305.pdf