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4-Nonylphenol (4-NP) is a well-known endocrine-disrupting chemical that could be present in the aquatic environment, but little is known about its oxidative stress effects. An emerging literature suggests that early life exposure to 4-NP may increase the risk of metabolic syndrome. Due to its hydrophobicity and long half-life, 4-NP can easily accumulate in living organisms, including humans, where it inflicts a series of toxic effects. In the present study, the oxidative stress and antioxidant parameters of Labeo rohita after exposure to various sub-lethal concentrations of 4-NP for 5, 10 and 15 days were examined. The level of glutathione content and the activity of glutathione peroxidase and glutathione-s-transferase were significantly inhibited, whereas the activity of superoxide dismutase, catalase and glutathione reductase and the lipid peroxidation products such as malondialdehyde and conjugated diene were significantly elevated, indicating the occurrence of oxidative stress. The results demonstrate that 4-NP in aquatic systems can affect antioxidant responses.

Keywords

Antioxidants, Endocrine-Disrupting Chemical, 4-Nonylphenol, Oxidative Stress.

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References

Agergaard N, Jensen PT. Procedure for blood glutathione peroxidase determination in cattle and swine. Acta Vet Scand. 1982; 23:515-27.

Ahmad I, Hamid T, Fatima M, Chand HS, Jain SK, Athar M, Raisuddin S. Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure. Biochem Biophys Acta. 2000; 1523:37-48. https://doi.org/10.1016/S0304-4165(00)00098-2

Amin KA, Hashem KS. Deltamethrin-induced oxidative stress and biochemical changes in tissues and blood of catfish (Clarias gariepinus): antioxidant defense and role of alpha-tocopherol. BMC Vet Res. 2012; 8:45. https://doi.org/10.1186/1746-6148-8-45 PMid:22537979 PMCid:PMC3482145

Benke GM, Cheevar KC. The comparative toxicity, acetylcholinesterase action and metabolism of methyl parathion and parathion in sunfish and mice. Toxicol Appl Pharmacol. 1974; 28:97-109. https://doi.org/10.1016/0041008X(74)90135-5

Bernadac-Villegas LG, Solís-Casados DA, Corral-Avitia AY, Galar-Martínez M, Islas-Flores H, Dublán-García O, Gómez-Oliván LM. As2O3 induces oxidative stress in gill, liver, brain and blood of Cyprinus carpio. Electronic J Biol. 2016; 12:1.

Bradford MM. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72:248-54. https://doi.org/10.1016/0003-2697(76)90527-3

David M, Richard JS. Methods of enzymatic analysis. In: Bergmeyer J, Mariare GB (eds.) Verlag Chemie Wenhein Deer Field, Beach Floride. 1983; 26:358-59.

de Haan JB, Cristiano F, Iannello RC, Kola I. Cu/ Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem Mol Biol Int. 1995; 35:1281-97.

Desai TH. Toxicological studies of methanol on Superoxide dismutase (SOD) activity of freshwater fish Cirrhinus mrigala. Int J of Fish and Aqua Stud. 2018; 6(5):20-22.

Di Giulio RT. Biochemical responses in aquatic animals: A review of determinants of oxidative stress. Environ Toxicol Chem. 1989; 8: 1103-23. https://doi.org/10.1002/ etc.5620081203

Dimitrova MST, Tsinova V, Velcheva V. Combined effects of zinc and lead on the hepatic superoxide dismutase-catalase system in carp (Cyprinus carpio). Comp Biochem Physiol Part C. 1994; 108:43-6. https://doi.org/10.1016/13678280(94)90087-6

Dittmar M, Knuth M, Beineke M, Epe B. Role of oxidative DNA damage and antioxidative enzymatic defence systems in human aging. Open Anthropol J. 2008; 1:38-45. https:// doi.org/10.2174/1874912700801010038

Duncan DB. Multiple range and multiple F- tests. Biometrics.1995; 11:1-42. https://doi.org/10.2307/3001478

Emmanuel OO, Stanley CI, Christopher DN, Christian EM, Ogochukwu CO, Ibrahim BU. Toxicity of diazepam on lipid peroxidation, biochemical and oxidative stress indicators on liver and gill tissues of African catfish Clarias gariepinus (Burchell, 1822). Int J of Fish and Aqua Stud. 2017; 5(3):114-23.

European Commission (EC). European Union Risk Assessment Report 4-nonylphenol (branched) and nonylphenol. 2002.

Farombi EO, Ajimoko YR, Adelowo OA. Effect of butachlor on antioxidant enzyme status and lipid peroxidation in freshwater African catfish (Clarias gariepinus). Int J Environ Res Pub Health. 2008; 5:423-27. https://doi.org/10.3390/ ijerph5050423 PMid:19151438 PMCid:PMC3700003

Filho DW, Giulivi C, Boveris A. Antioxidant defenses in marine fish. 1 Teleosts. Comp Biochem Physiol. 1993; 106: 409-413. https://doi.org/10.1016/0742-8413(93)90154-D

Garaiova G, Muchova J, Sustrova M, Blazicek P, Sivonova M, Kvasnicka P, Pueschel S, Durackova Z. The relationship between antioxidant systems and some markers of oxidative stress in persons with Down syndrome. Biologica Bratislava. 2004; 59(6): 787-94.

Geret F, Serafim A, Barreira L, Bebianno MJ. Effect of cadmium on antioxidant enzyme activities and lipid peroxidation in the gills of the clam Ruditapes decussatus. Biomarkers. 2002; 7(3): 242-56. https://doi.org/10.1080/13547500210125040 PMid:12141067

Gul S, Belge-Kurutas E, Yildiz E, Sahan A, Doran F. Pollution correlated modifications of liver antioxidant systems and histopathology of fish (Cyprinidae) living in Seyhan Dam Lake, Turkey. Environ Int. 2004; 30:605-09. https://doi.org/10.1016/S0160-4120(03)00059-X

Habig WH, Pabst MJ, Jakoby WB. Glutathione-Stransferases: The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249:7130-39.

Halliwell B, Gutteridge JMC (Eds). Free Radicals in Biology and Medicine. 3rd Edition, Oxford University Press, Oxford, 1999. p. 1-25.

Hamilton F. An account of the fishes found in the river Ganges and its branches. Edinburgh & London, 1822. p. 1-405. https://doi.org/10.5962/bhl.title.59540

Kakkar P, Das B, Viswanathan PN. A modified spectroscopic assay of superoxide dismutase. Indian J Biochem Biophys. 1984; 21:130-32.

Kwan HP. Alteration of hepatic antioxidant systems by 4-Nonylphenol, a metabolite of alkylphenol polyethoxylated detergents, in Far Eastern catfish, Silurus asotus. Environ Health Toxicol. 2015; 30:573-701. https://doi.org/10.5620/ eht.e2015006 PMid:26602557 PMCid:PMC4548496

Lawrence RA, Burck RA. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 1976; 71:952-58. https://doi.org/10.1016/0006291X(76)90747-6

Maehly AC, Chance B. The assay of catalase and peroxide. In: Glick D (ed.) Methods of Biochemical Analysis I.Interscience: New York. 1954; 1:357. https://doi.org/10.1002/9780470110171.ch14 PMid:13193536

Maiti S, Chatterjee AK. Effects on levels of glutathione and some related enzymes in tissues after an acute arsenic exposure in rats and their relationship to dietary protein deficiency. Arch Toxicol. 2001; 75(9):531-37. https://doi.org/10.1007/s002040100240 PMid:11760813

Newbold R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: Implications for other environmental estrogens. Environ. Health Perspect. 1995; 103:83-7. https://doi.org/10.1289/ehp.95103s783 PMid:8593881 PMCid:PMC1518878

Nichans WG, Sannelson D. Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation. Eur J Biochem. 1968; 6:126-130. https://doi.org/10.1111/j.1432-1033.1968.tb00428.x PMid:4387188

Nwani CD, Lakra WS, Naqpure NS, Kumar R, Kushwaha B, Srivastava SK. Toxicity of the herbicide atrazine: effects on lipid peroxidation and activities of antioxidant enzymes in the freshwater fish, Channa punctatus. Int J of Environ Res and Pub Health. 2010; 7:3298-312. https://doi.org/10.3390/ ijerph7083298 PMid:20948961 PMCid:PMC2954582

Oliveira M. Organ specific antioxidant responses in golden grey mullet (Liza aurata) following a short-term exposure to phenanthrene. Sci Total Environ. 2008; 396:70-8. https:// doi.org/10.1016/j.scitotenv.2008.02.012 PMid:18358514

Oluwatosin AA, Abiola MA. Effect of environmental pollution on oxidative stress biomarkers in African catfish (Clarias gariepinus) from Asejire River in Oyo state, Nigeria. J Environ Occup Sci. 2016; 5(4):71-76. https://doi.org/10.5455/jeos.20161122030636

Organisation for Economic Co-operation and Development (OECD). Guidance Document on standardised test guidelines for evaluating chemicals for endocrine disruption. 2012; 1-524.

Padmini E, Vijaya GB, Usha RM. Liver oxidative stress of the grey mullet, Mugil cephalus, presents seasonal variations in Ennore estuary. Braz J Med Bio Res. 2008; 41(11):95155. https://doi.org/10.1590/S0100-879X2008005000038 PMid:18853043

Palermo FA, Mosconi G, Angeletti M, Polzonetti-Magni AM. Assessment of water pollution in the Tronto River (Italy) by applying useful biomarkers in the fish model Carassius auratus. Arch Environ Contam Toxicol. 2008; 55(2):295-304. https://doi.org/10.1007/s00244-007-9113-2 PMid:18214578

Pannunzio TM, Storey KB. Antioxidant defenses and lipid peroxidation during anoxia stress and aerobic recovery in the marine gastropod Littorina littorea. J Exp Mar Bio and Ecol. 1998; 221: 277-92. https://doi.org/10.1016/S00220981(97)00132-9

Perez-Lopez M, Novoa-Valinas MC, Nlelgar-Riol MJ. Glutathione-S-transferasecytosolic isoforms as biomarkers of polychlorinated biphenyl experimental contamination in rainbow trout. Toxicol Lett. 2002; 136:97-106. https://doi.org/10.1016/S0378-4274(02)00284-9

Raja P, Puvaneswari S. Heavy metal lead nitrate induced toxic effects on enzymatic and non-enzymatic antioxidant activities in selected tissues of the fish Labeo rohita fingerlings. Int J of Zool Stud. 2017; 2:58-62

Recknagel RO, Goshal AK. Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning. Exp Mol Pathol. 1966; 5:413-26. https://doi.org/10.1016/0014-4800(66)90023-2

Sanchez W, Pallulel O, Meunier L, Coquery M, Porcher JM, Ait-Aissa S. Copper-induced oxidative stress in three-spined stickleback: relationship with hepatic metal levels. Environ Toxicol Pharmacol. 2005; 19:177-183. https://doi.org/10.1016/j.etap.2004.07.003 PMid:21783474

Sedeno-Diaz JE, Lopez-Lopez E. Freshwater fish as sentinel organisms: from the molecular to the population level, a review. In Turker H (ed.). New Advances and Contributions to Fish Biology. 2013; 4:151-73

Statistical Package for Social Sciences (SPSS). IBM SPSS Statistics for Windows, Version 22.0. IBM Corp Armonk NY. 2013.

Tanu A, Awasthi A, Rana SVS. Fish chromatophores as biomarkers of arsenic exposure. Environ Biol Fishes. 2004; 71:7-11. https://doi.org/10.1023/B:EBFI.0000043145.58953.86

Teles M, Pacheco M, Santos MA. Sparus aurata L. Liver EROD and GST activities, plasma cortisol, lactate, glucose and erythrocytic nuclear anomalies following short-term exposure either to 17 beta-estradiol (E2) or E2 combined with 4-nonylphenol. Sci Total Environ. 2005; 336(13):57-69. https://doi.org/10.1016/j.scitotenv.2004.05.004 PMid:15589249

U.S. Environmental Protection Agency (U.S.EPA). Aquatic Life Ambient Water Quality Criteria - Nonylphenol. 2005.

Vieira CED, Almeira MS, Galindo BA, Pereira L, Martinez CBR. Integrated biomarker response index using a neotropical fish to assess the water quality in agricultural areas. Neotrop Ichthyol. 2014; 12: 153-64. https://doi.org/10.1590/S1679-62252014000100017

Xueji L, Liting Z, Yiping N, Aiqing W, Mingjiang H, Yao L, Chengjiao H, Jianmei W, Bin C, Lijun F, Jian T, Xing T, Shasha T, Hailin T. Nonylphenol induces pancreatic damage in rats through mitochondrial dysfunction and oxidative stress. Toxicol Res (Camb). 2017; 6(3):353-60. https://doi.org/10.1039/C6TX00450D PMid:30090504 PMCid:PMC6062391

Yilmaz HR, Turkoz Y, Yukse, E, Orun I. An investigation of antioxidant enzymes activities in the liver of Cyprinus carpio taken from different stations in the Karakaya Dam Lake. Int J Sci Tech. 2006; 1:1-6.

Zhang J, Shen H, Wang X, Wu J, Xue Y. Effects of chronic exposure of 2,4- dichlorophenol on the antioxidant system in the liver of freshwater fish Carassius auratus. Chemosphere. 2004; 55(2):167-74. https://doi.org/10.1016/j.chemosphere.2003.10.048 PMid:14761689

Impact of Bisphenol S as an Endocrine Disruptor in a Freshwater Fish, Oreochromis mossambicus

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Authors

V. R. Anjali ¹, V. S. Remya ¹, S. Reshmi ¹, S. Shehna Mahim ¹, C. Aruna Devi ¹

Affiliations
1 Department of Zoology, University College, Thiruvananthapuram - 695034, Kerala, IN

Source

Journal of Endocrinology and Reproduction, Vol 23, No 2 (2019), Pagination: 49-63

Abstract

Endocrine Disrupting Chemicals (EDCs) have the potential to alter the hormonal pathways concerned with regulation of the normal homeostatic mechanisms. The adverse effects of EDCs can be observed in areas where pollution is high, particularly in aquatic ecosystems, where persistent environmental chemicals accumulate. In the present study, we investigated the endocrine disrupting effects of Bisphenol S (BPS), if any, in the levels of thyroxine, triiodothyronine, cortisol and sex steroidal [17βestradiol (E2) and testosterone(T)] hormones in juvenile as well as adult Oreochromis mossambicus. Drastic changes in serum thyroxine and triiodothyronine levels showed that BPS treatment resulted in disruption of thyroid gland function. Alteration to significant levels in serum cortisol indicated acute stress and impairment of hypothalamic-pituitaryinterrenal axis. Significant changes (p<0.05) occurred in the steroidal hormone levels which are biomarkers of endocrine disruption as they affect hypothalamic-pituitary-gonadal axis in fish. Bisphenol S also revealed estrogenic potency by inducing significant alteration in the E2/T ratio. DNA fragmentation, if any, induced by BPS was also analyzed in juvenile fish. There was no significant DNA fragmentation observed in gel electrophoresis, but a significant elevation was seen in percent fragmented DNA in the diphenylamine method. Therefore, it could be concluded that BPS at different sublethal concentrations have a profound impact on endocrine physiology of fish.

Keywords

Bisphenol S, DNA Fragmentation, Endocrine Disruption, Thyroxine, Triiodothyronine

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References

Kinnberg K, Toft G. Effects of estrogenic and antiandrogenic compounds on the testis structure of the adult guppy (Poecilia reticulata). Ecotoxicol Environ Saf. 2003; 54:1624. doi.org/10.1016/s0147-6513 (02)00010-6. https://doi.org/10.1016/S0147-6513(02)00010-6.

Marino M, Pellegrini M, La Rosa P, Acconcia F. Susceptibility of estrogen receptor rapid responses to xenoestrogens: Physiological outcomes. Steroids. 2012; 77:910-917. https:// doi.org/10.1016/j.steroids.2012.02.019. PMid:22410438

Ropero AB, Alonso-Magdalena P, Ripoll C, Fuentes E, Nadal A. Rapid endocrine disruption: environmental estrogen actions triggered outside the nucleus. J Steroid Biochem Mol Biol. 2006; 102:163-169. https://doi.org/10.1016/j.jsbmb.2006.09.019. PMid:17084624.

Tabb MM, Blumberg B. New modes of action for endocrinedisrupting chemicals. Mol Endocrinol. 2006; 20:475-482. https://doi.org/10.1210/me.2004-0513. PMid:16037129.

Scholz S, Mayer I. Molecular biomarkers of endocrine disruption in small model fish. Mol Cell Endocrinol. 2008; 293: 57-70. https://doi.org/10.1016/j.mce.2008.06.008. PMid:18619515.

Mendil D, Demirci Z, Tuzen M, Soylak M. Seasonal investigation of trace element contents in commercially valuable fish species from the black sea, Turkey. Food Chem Toxicol. 2010; 48: 865-870. https://doi.org/10.1016/j.fct.2009.12.023. PMid:20036302.

Erler C, Novak J. Bisphenol A exposure: Human risk and health policy. J Pediatr Nurs. 2010; 25:400-407. https://doi.org/10.1016/j.pedn.2009.05.006. PMid:20816563.

Asimakopoulos AG, Thomaidis NS, Koupparis MA. Recent trends in biomonitoring of bisphenol A, 4-t-octylphenol, and 4-nonylphenol. Toxicol Lett. 2012; 210:141-154. https://doi.org/10.1016/j.toxlet.2011.07.032. PMid:21888958.

European Commission (EC). Bisphenol A: EU ban on baby bottles to enter into force tomorrow. European Union, Brussels. 2011.

US Food and Drug Administration. Update on bisphenol A for use in food contact applications. Silver Spring (MD): US Food and Drug Administration. 2010.

Health Canada. Government of Canada acts to protect newborns and infants from bisphenol A in polycarbonate plastic baby bottles. 2009.

Liao C, Liu F, Kannan K. Bisphenol S, a new bisphenol analogue, in paper products and currency bills and its association with bisphenol A residues. Environ Sci Technol. 2012; 46:6515-6522. https://doi.org/10.1021/es300876n. PMid:22591511.

Lotti N, Colonna M, Fiorini M, Finelli L, Berti C. Poly(butylene terephthalate) modified with ethoxylated bisphenol S with increased glass transition temperature and improved thermal stability. Polymer. 2011; 52:904-911. https://doi.org/10.1016/j.polymer.2011.01.018.

Naderi M, Wong MYL, Gholami F. Developmental exposure of zebrafish (Danio rerio) to bisphenol-S impairs subsequent reproduction potential and hormonal balance in adults. Aquat Toxicol. 2014; 148:195-203. https://doi.org/10.1016/j.aquatox.2014.01.009. PMid:24508763.

Ji K, Hong S, Kho Y, Choi K. Effects of bisphenol S exposure on endocrine functions and reproduction of zebra fish. Environ Sci Technol. 2013; 47:8793-8800. https://doi.org/10.1021/es400329t. PMid:23806087.

Nelson JC, Wilcox RB. Analytical performance of free and total thyroxine assays. Clin Chem.1996; 42:146-154. https://doi.org/10.1093/clinchem/42.1.146.

Bablok W. A general regression procedure for method transformation. Application of linear regression procedures for method comparison studies in clinical chemistry, Part III. J Clin Chem Clin Biochem. 1988; 26:783-790. https:// doi.org/10.1515/cclm.1988.26.11.783. PMid:3235954.

Iqbal MJ, Dalton M, Sawers RS. Binding of testosterone and estradiol to sex hormone binding globulin, human serum albumin and other plasma proteins: Evidence for non-specific binding of estradiol to sex hormone binding globulin. Clin Sci. 1983; 64:307-314. https://doi.org/10.1042/cs0640307. PMid:6681600.

Wheeler MJ. The determination of bio-available testosterone. Ann Clin Biochem. 1995; 32:345-357. https:// doi.org/10.1177/000456329503200401. PMid:7486793.

Iwasa M, Maeno Y, Inoue H, Koyama H, Matoba R. Induction of apoptotic cell death in rat thymus and spleen after a bolus injection of methamphetamine. Int J Legal Med. 1996; 109:23-28. https://doi.org/10.1007/ BF01369597. PMid:8876318.

Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 1996; 274:1710-1713. https://doi.org/10.1126/science.274.5293.1710. PMid:8939861.

Duncan DB. Multiple Range and Multiple F Tests. Biometrics. 1995; 11:1-42. https://doi.org/10.2307/3001478.

Hecker M, Tyler CR, Hoffmann M Maddix S, Karbe I. Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe river, Germany. Environ Sci Technol. 2002; 36:2311-2321. https://doi.org/10.1021/ es010186h. PMid:12075783.

Soffker M, Tyler CR. Endocrine disrupting chemicals and sexual behaviors in fish - a critical review on effects and possible consequences. Crit Rev Toxicol. 2012; 42:653668. https://doi.org/10.3109/10408444.2012.692114. PMid:22697575.

Wendelaar Bonga SE. The stress response in fish. Physiol Rev. 1997; 77:591-625. https://doi.org/10.1152/ physrev.1997.77.3.591. PMid:9234959.

Mommsen TP, Vijayan MM, Moon TW. Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation. Rev Fish Biol Fish. 1999; 9: 211-268. https://doi.org/10.1023/A:1008924418720.

Norris DO. Vertebrate Endocrinology, 3rd ed. Academic Press, Inc., San Diego. 1997.

Barton BA. Stress in fishes: A diversity of responses with particular reference to changes in circulating corticosteroids. Integr Comp Biol. 2002; 42:517-525. https://doi.org/10.1093/icb/42.3.517. PMid:21708747.

Bury NR, Eddy FB, Codd GA. Stress responses of brown trout, Salmo Trutta L., to the cyanobacterium, Microcystis aeruginosa. Environ Toxicol Water Qual.1996; 11:187-193. https://doi.org/10.1002/(SICI)10982256(1996)11:3<187::AID-TOX3>3.0.CO;2-5.

Ernst B, Hoeger SJ, O’Brien E, Dietrich DR. Physiological stress and pathology in European whitefish (Coregonus lavaretus) induced by subchronic exposure to environmentally relevant densities of Planktothrix rubescens. Aquat Toxicol. 2007; 82:15-26. https://doi.org/10.1016/j.aquatox.2007.01.007. PMid:17320197.

Donaldson EM, Dye HM. Corticosteroid concentrations in sockeye salmon (Oncorhynchus nerka) exposed to low concentrations of copper. J Fish Res Bd Can. 1975; 33:533539. https://doi.org/10.1139/f75-065.

Hill CW, Fromm PO. Response of interrenal gland of rainbow trout (Salmo gairdneri) to stress. Gen Comp Endocrinol. 1968; 11:69-77. https://doi.org/10.1016/00166480(68)90108-1.

James VA, Wigham T. The effects of cadmium on prolactin cell activity and plasma cortisol levels in the rainbow trout (Salmo gairdneri). Aquat Toxicol. 1986; 8:273-280. https:// doi.org/10.1016/0166-445X(86)90079-2.

Richard AC, Daniel C, Anderson P, Hontela A. Effect of subchronic exposure to cadmium chloride on endocrine and metabolic functions in rainbow trout (Onchorhynchus mykiss). Arch Environ Contam Toxicol. 1998; 34:377-381. https://doi.org/10.1007/s002449900333. PMid:9543508.

Pandya P, Upadhyay A, Thakkar B, Parikh P. Evaluating the toxicological effects of agrochemicals on glucocorticoid receptor and serum cortisol level in Mozambique tilapia. Cogent Biol. 2018; 4:1. https://doi.org/10.1080/23312025.2 018.1480338.

Ezemonye LIN, Ikpesu TO. Evaluation of sublethal effects of endosulfan on cortisol secretion, glutathione s-transferase and acetycholinesterase activities in Clarias gariepinus. Food Chem Toxicol. 2010; 49:1898-1903. https://doi.org/10.1016/j.fct.2010.10.025. PMid:21056611.

Thangavel P, Sumathiral K, Maheswari S, Rita S, Ramaswamy M. Hormone profile of an edible, freshwater teleost, Sarotherodon mossambicus (Peters) under endosulfan toxicity. Pest Biochem Physiol. 2010; 97:229-234. https:// doi.org/10.1016/j.pestbp.2010.03.001.

Akhtar SM, Pal AK, Sahu NP, Alexander C, Gupta SK, Choudhar AK, Rajan MG. Stress mitigating and immunomodulatory effect of dietary pyridoxine in Labeo rohita (Hamilton) fingerlings. Aquac Res. 2010; 41:9911002. https://doi.org/10.1111/j.1365-2109.2009.02383.x.

Martínez-Porchas M, Martínez-Córdova LR, RamosEnriquez R. Cortisol and glucose: reliable indicators of fish stress. Pan-American J Aquat Sci. 2009; 4:158-178.

Campinho MA. Teleost metamorphosis: The role of thyroid hormone. Front Endocrinol. 2019; 10:383. https:// doi.org/10.3389/fendo.2019.00383. PMid:31258515 PMCid:PMC6587363.

Blanton ML, Specker JL. The Hypothalamic-PituitaryThyroid (HPT) axis in fish and its role in fish development and reproduction. Crit Rev Toxicol. 2007; 37:97-115. https:// doi.org/10.1080/10408440601123529. PMid:17364706.

Van der Geyten S, Mol KA, PluymersW, Kühn ER, Darras VM. Changes in plasma T3 during fasting/refeeding in tilapia (Oreochromis niloticus) are mainly regulated through changes in hepatic type II iodothyronine deiodinase. Fish Physiol Biochem.1998; 19:135-143. https://doi.org/10.1023/A:1007790527748.

Ruby SM, Idler DR, So YP. Plasma vitellogenin, 17βestradiol, T3 and T4 levels in sexually maturing rainbow trout, Oncorhynchus mykiss following sublethal HCN exposure. Aquat Toxicol. 1993; 26:91-101. https:// doi.org/10.1016/0166-445X(93)90007-N.

Abdolali M, Negin S, Parvin K. Effects of the environmental endocrine disrupting compound benzo[a] pyrene on thyroidal status of Abu mullet (Liza abu) during shortterm exposure. Toxicol Rep. 2018; 5:377-382. https:// doi.org/10.1016/j.toxrep.2018.02.018. PMid:29854607 PMCid:PMC5977374.

Cao C, Wang Q, Jiao F, Zhu G. Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish. Experiment Toxicol Pathol. 2016; 68(8):463-469. https://doi.org/10.1016/j.etp.2016.07.004. PMid:27480594.

Yu L, Chen M, Liu Y, Gui W, Zhu G. Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole. Aquat Toxicol. 2013; 138139:35-42. https://doi.org/10.1016/j.aquatox.2013.04.001. PMid:23685399.

Teles M, Santos MA, Pacheco M. Physiological and genetic responses of European eel (Anguilla anguilla) to short-term chromium or copper exposure- influence of pre exposure to a PAH-like compound. Environ Toxicol. 2005; 20:92-99. https://doi.org/10.1002/tox.20082. PMid:15712285.

Li D, Xie P, Zhang XZ. Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins. Chemosphere. 2008; 74: 13-18. https://doi.org/10.1016/j. chemosphere.2008.09.065. PMid:18990424.

Morgado I, Campinho MA, Costa R, Jacinto R, Power DM. Disruption of the thyroid system by diethylstilbestrol and ioxynil in the sea bream (Sparus aurata). Aquat Toxicol. 2009; 92:271-280. https://doi.org/10.1016/j.aquatox.2009.02.015. PMid:19375178.

Guo Y, Zhou B. Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay. Aquat Toxicol. 2013; 142-143:138-145. https://doi.org/10.1016/j.aquatox.2013.08.005. PMid:24001430.

McCormick SD, O’Dea MF, Moeckel AM, Lerner DT, Björnsson BT. Endocrine disruption of parr-smolt transformation and seawater tolerance of Atlantic salmon by 4-nonylphenol and 17βestradiol. Gen Comp Endocrinol. 2005; 142:280-288. https://doi.org/10.1016/j.ygcen.2005.01.015. PMid:15935154.

Zhang DH, Zhou EX, Yang ZL. Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLOS ONE. 2017; 12(5):e0176927. https://doi.org/10.1371/journal.pone.0176927. PMid:28467477 PMCid:PMC5415059.

Power DM, Llewellyn L, Faustino M, Nowell MA, Björnsson BT, Einarsdottir IE, Canario AV, Sweeney GE. Thyroid hormones in growth and development of fish. Comp Biochem Physiol C Toxicol Pharmacol. 2001; 130(4):447459. https://doi.org/10.1016/S1532-0456(01)00271-X.

Stephens SM, Brown JA, Frankling SC. Stress responses of larval turbot, Scophthalmus maximus L, exposed to sublethal concentrations of petroleum hydrocarbons. Fish Physiol Biochem. 1997; 17:433-439. https://doi.org/10.1023/A:1007799928020.

Waring CP, Moore A. The effect of atrazine on Atlantic salmon (Salmo salar) smolts in freshwater and after seawater transfer. Aquat Toxicol. 2004; 66:93-104. https:// doi.org/10.1016/j.aquatox.2003.09.001. PMid:14687982.

Heuer H, Visser Th. J. Pathophysiological importance of thyroid hormone transporters. Endocrinology. 2009; 150:1078-1083. https://doi.org/10.1210/en.2008-1518. PMid:19179441.

Hess RA. Estrogen in the adult male reproductive tract: A review. Reprod Biol Endocrinol. 2003; 1:52. https:// doi.org/10.1186/1477-7827-1-52. PMid:12904263 PMCid:PMC179885.

Chaves-Pozo E, Arjona FJ, García-López A, García-Alcázar A, Meseguer J, García-Ayala A. Sex steroids and metabolic parameter levels in a seasonal breeding fish (Sparus aurata L). Gen Comp Endocrinol. 2008; 156:531-536. https://doi.org/10.1016/j.ygcen.2008.03.004. PMid:18407272.

Valero Y, Miriam Sánchez-Hernández M, Alicia GarcíaAlcázar A, Alfonsa García-Ayala A, Alberto Cuesta A, Elena Chaves-Pozo E. Characterization of the annual regulation of reproductive and immune parameters on the testis of European sea bass. Cell Tissue Res. 2015; 362:215-229. https://doi.org/10.1007/s00441-015-2172-1. PMid:25896883.

Aruna Devi C. Role of Bisphenol A as an endocrine disruptor in a freshwater fish, Anabas testudineus, PhD Thesis. University of Kerala, Thiruvananthapuram, India. 2013.

Naderi M, Zargham D, Asadi A, Bashti T, Kamayi K. Short-term responses of selected endocrine parameters in juvenile rainbow trout (Oncorhynchus mykiss) exposed to 4-nonylphenol. Toxicol Ind Health. 2015; 31:12181228. https://doi.org/10.1177/0748233713491806. PMid:23771873.

Spanò L, Tyler CR, Aerle RV, Devos P, Mandiki SNM, Silvestre F, Thomé JP, Kestemont P. Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus). Aquat Toxicol. 2004; 66(4):369-379. https://doi.org/10.1016/j.aquatox.2003.10.009. PMid:15168945.

Mills LJ, Chichester C. Review of evidence: Are endocrinedisrupting chemicals in the aquatic environment impacting fish populations? Sci Total Environ. 2005; 343:1-34. https://doi.org/10.1016/j.scitotenv.2004.12.070. PMid:15862833.

Nakamura D, Yanagiba Y, Duan Z, Ito Y, Okamura A, Asaeda N. Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol. Toxicol Lett. 2010; 194:16-25. https://doi.org/10.1016/j.toxlet.2010.02.002. PMid:20144698.

Yang Q, Yang X, Liu J, Ren W, Chen Y, Shen S. Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic-pituitary-gonadal axis of zebrafish. Environ Sci Pollut Res Int. 2017; 24:21311-21322. https:// doi.org/10.1007/s11356-017-9773-z. PMid:28741210.

Webb P, Nguyen P, Kushner PJ. Differential SERM effects on corepressor binding dictate ERα activity in vivo. J Biol Chem. 2003; 278:6912-6920. https://doi.org/10.1074/jbc.M208501200. PMid:12482846.

Hinck JE, Blazer VS, Denslow ND, Meyers MS, Gross TS, Tillitt DE. Biomarkers of contaminant exposure in Northern Pike (Esox lucius) from the Yukon River Basin, Alaska. Arch Environ Contam Toxicol. 2007; 52:549-562. https:// doi.org/10.1007/s00244-006-0134-z. PMid:17396212.

Dutta HM, Nath A, Adhikari S, Roy PK, Singh NK, Datta Munshi JS. Sublethal malathion induced changes in the ovary of an air-breathing catfish, Heteropneustes fossilis. A histological study. Hydrobiologia. 1994; 294:215-218.

https://doi.org/10.1007/BF00021294.

Dogan D, Can C. Endocrine disruption and altered biochemical indices in male Oncorhynchus mykiss in response to dimethoate. Pest Biochem Physiol. 2011; 99:157-161. https://doi.org/10.1016/j.pestbp.2010.11.012.

Folmar LC, Denslow ND, Rao V, Chow M, Crain DA, Enblom J, Marcino J, Guillete LJ. Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ Health Perspect. 1996; 104:1096-1101. https://doi.org/10.1289/ehp.961041096.

PMid:8930552 PMCid:PMC1469501.

Borg B. Androgens in teleost fishes. Comp Biochem Physiol. 1994; 109C:219-245. https://doi.org/10.1016/0742-8413(94)00063-G.

Bergh A. Paracrine regulation of Leydig cells by the seminiferous tubules. Int J Androl. 1983; 6:57-65. https://doi.org/10.1111/j.1365-2605.1983.tb00323.x. PMid:6840880.

Park CB, Aoki JY, Lee JS, Nagae M, Lee YD, Sakakura Y, Hagiwara A, Soyano K. The effects of 17β estradiol on various reproductive parameters in the hermaphrodite fish Kryptolebias marmoratus. Aquat Toxicol. 2010; 96(4):273-279. https://doi.org/10.1016/j.aquatox.2009.11.006. PMid:20006390.

Labadie P, Budzinski H. Alteration of steroid hormone profile in juvenile turbot (Psetta maxima) as a consequence of short-term exposure to 17α-ethynylestradiol. Chemosphere. 2006; 64:1274-1286. https://doi.org/10.1016/j.chemosphere.2005.12.065. PMid:16490234.

Sayed AEDH, Mahmoud UM, Mekkawy IA. Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol. Ecotoxicol Environ Saf. 2012; 78:310-319. https://doi.org/10.1016/j.ecoenv.2011.11.041. PMid:22177982.

Hunter GA, Donaldson EM. Hormonal sex control and its application to fish culture. In W.S. Hoar, D.J. Randall and E.M. Donaldson (eds). Fish Physiol. Vol. IX B, New York: Academic Press. 1983; 1:223-303. https://doi.org/10.1016/ S1546-5098(08)60305-2.

Baldigo BP, Sloan RJ, Smith SB, Denslow ND, Blazer VS, Gross TS. Polychlorinated biphenyls, mercury, and potential endocrine disruption in fish from the Hudson River, New York, USA. Aquat Sci. 2006; 68:206-228. https:// doi.org/10.1007/s00027-006-0831-8.

Folmar LC, Denslow ND, Kroll K, Orlando EF, Enblom J, Marcino J, Metcalfe C, Guillete LJ. Altered serum sex steroids and vitellogenin induction in walleye (Stizostedion citreum) collected near a metropolitan sewage treatment plant. Arch Environ Contam Toxicol. 2001; 40:392-398. https://doi.org/10.1007/s002440010188. PMid:11443371.

Connell D, Lam P, Richardson B, Wu R. Introduction to ecotoxicology. Oxford, UK: Blackwell Science; 1999.

Steinert SA. DNA damage as a bivalve biomarker. Biomarkers. 1999; 4:492-496. https://doi.org/10.1080/135475099230651. PMid:23902394.

Black MC, Ferell JR, Horning RC, Martin LK. DNA strand breakage in freshwater mussels (Anodonta grandis) exposed to lead in laboratory and field. Environ Toxicol Chem.1996; 15:802-808. https://doi.org/10.1002/etc.5620150528.

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