Journal of Endocrinology and Reproduction

R. Ilangovan ¹, S. Sitta-Djody ¹, H. M. Balaganes ¹, N. A. Jayavelan ², M. S. Holi ², N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medicai Sciences, Chennai 600113, IN
2 Institute Hospital, Biomedical Engineering Division, IIT Madras, Chennai 600 036, IN

Abstract

Osteoporosis is characterized by impairment of bone mass and deterioration of bone microscopic structure, resulting in increased bone fragility and susceptibility to fracture. Osteoporosis is considered as a postmenopausal woman's disease; however, recent studies indicate that the effects of this disease in men are at least as severe as in women. Insulin-like growth factors (IGFs) and its binding proteins (IGFBPs) are known to influence the bone physiology.

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S. Sitta-Djody ¹, R. Ilangovan ¹, M. Balaganesh ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Abstract

The age-related defects in osteoblast number and function may be due to quantitative and qualitative stem cell defects. Early commitment and conversion of bone marrow stem cells (BMSCs) towards osteoblastic lineage is a critical step in the process of bone formation and bone remodeling, which is regulated by various systemic hormones and local factors. There are a few studies that analyze whether changes in the functional characteristics of osteoblastic progenitor cells, the BMSCs.

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P. Kanagaraj ¹, M. R. Vijayababu ¹, S. Sitta-Djody ¹, N. Srinivasan ¹, M. M. Aruldhas ¹, P. Govindarajulu ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALMPGIBMS, University of Madras, Taramani, Chennai - 600 113, IN

Abstract

Insulin like growth factors have been implicated in the regulation of prostate epithelial cell proliferation and induction of prostate cancer. Estrogens play an important role in prostate physiology and disease development. E₂ has been reported to regulate the production of IGFs and IGFBPs in prostate cell lines. Hence, it is attempted to study the effects of E₂ on the production of IGFs and IGFBPs in PC-3 cell line. The PC-3 cells (1x10⁵ cells/ well) were treated with different doses of E₂ (1,10 and 10 nM) for 24 hrs and 48 hrs, the conditioned media were collected and assayed for IGF-I and IGFBP-5. Dose and duration dependent effect of E₂ on IGF-I and IGFBP-5 on PC-3 eel lines will be discussed with available literature.

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