Journal of Endocrinology and Reproduction

Srinivasan, N.

• Studies on Certain Serum Biochemical Profiles and Bone Mineral Density in Normal and Osteoporotic Men

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Authors

R. Ilangovan ¹, S. Sitta-Djody ¹, H. M. Balaganes ¹, N. A. Jayavelan ², M. S. Holi ², N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medicai Sciences, Chennai 600113, IN
2 Institute Hospital, Biomedical Engineering Division, IIT Madras, Chennai 600 036, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 40-41

Abstract

Osteoporosis is characterized by impairment of bone mass and deterioration of bone microscopic structure, resulting in increased bone fragility and susceptibility to fracture. Osteoporosis is considered as a postmenopausal woman's disease; however, recent studies indicate that the effects of this disease in men are at least as severe as in women. Insulin-like growth factors (IGFs) and its binding proteins (IGFBPs) are known to influence the bone physiology.

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• Regulation of Rat Bone Marrow Stem Cells Differentiation into Osteoblasts and Mineralization by Estrogen

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Authors

S. Sitta-Djody ¹, R. Ilangovan ¹, M. Balaganesh ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 43-43

Abstract

The age-related defects in osteoblast number and function may be due to quantitative and qualitative stem cell defects. Early commitment and conversion of bone marrow stem cells (BMSCs) towards osteoblastic lineage is a critical step in the process of bone formation and bone remodeling, which is regulated by various systemic hormones and local factors. There are a few studies that analyze whether changes in the functional characteristics of osteoblastic progenitor cells, the BMSCs.

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• Studies on Biochemical and Hormonal Profiles and Bone Mineral Density in Pre and Post-Menopausal Diabetic Women

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Authors

V. Gopala Krishnan ¹, A. Sundaram ², C. R. Anand Mosses ², S. Raghunandanan ³, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN
2 Department of Diabetology, Govt. Kilpauk Medical College and Hospital, Kilpauk, Chennai 600 010, IN
3 Department of Medicine, Govt. Kilpauk Medical College and Hospital, Kilpauk, Chennai 600 010, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 44-44

Abstract

A number of endocrine disorders, such as diabetes mellitus, hypogonadism and hyperparathyroidism have been associated with osteopenia and osteoporosis. Since diabetes mellitus and osteopenia are very common and of great socioeconomic relevance, interactions between both have become an interesting topic.

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• Effects of Experimental Diabetes and Insulin Replacement on Testicular Leydig Cells of Adult Rat

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Authors

S. Yuvaraj ¹, C. Parthasarathy ¹, N. Srinivasan ¹, P. Govindarajulu ¹, K. Balasubramanian ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 44-45

Abstract

Clinical and experimental studies have shown the adverse effects of diabetes on testicular steroidogenesis and spermatogenesis. The present study was designed to assess the effects of streptozotocin (STZ)-diabetes on Leydig cell LH receptors and steroidogenic enzymes. Diabetes was induced by single intraperitoneal injection of STZ at a dose of 65 mg/kg body weight. Induction of diabetes was confirmed by plasma insulin and glucose estimations. One set of diabetic rats was treated with insulin (3U/100g body weight/day in two equally divided doses), 3 days after STZ treatment. Control and experimental animals were killed after twenty days.

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• Anticancer Activity of Quercetin on Prostate Cancer Cell Line In vitro

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Authors

M. R. Vijayababu ¹, P. Kanagaraj ¹, A. Arunkumar ¹, Siva Dhanammal ¹, K. Balasubramanian ¹, N. Srinivasan ¹, M. M. Aruldhas ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 47-47

Abstract

Recent estimates have placed prostate cancer as the most commonly diagnosed malignancy. It is the fourth most common cancer in men worldwide. Androgen dependent prostate cancer can responds to androgen ablative therapy. However, if the cell contains heterogeneous population of both androgen dependent and androgen independent, the androgen ablative therapy can only responds to androgen dependent cell population but not to independent cancer.

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• Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro

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Authors

S. Rengarajan ¹, R. Sivakumar ¹, N. Srinivasan ¹, P. Govindarajulu ¹, K. Balasubramanian ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 54-55

Abstract

Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro.

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• Dose Dependent Effects of Gamma Radiation on LH and cAMP Stimulated Steroidogenesis in Cultured Human Leydig Cells

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Authors

R. Sivakumar ¹, J. Arunakaran ¹, N. Srinivasan ¹, P. Govindarajulu ¹, K. Balasubramanian ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 55-55

Abstract

Therapeutic or experimental radiation exposure is known to impair testicular Leydig cell function. However, the molecular mechanisms that underlie such effects are largely unknown. Our previous study demonstrated that higher doses of gamma radiation impair basal and LH-stimulated cAMP production. The present study deals with the dose dependent effects of gamma radiation on LH and cAMP stimulated steroidogenesis in human Leydig cells. Testicles removed from advanced prostatic carcinoma patients, who do not have any endocrine or metabolic disorders known to affect the testicular functions were used in the present study. Prior to orchidectomy, serum hormones such as FSH, LH, testosterone and estradiol were assayed to evaluate the testicular functions.

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• Effect of 17β-Estradiol (E₂) on the Production of Insulin Like Growth Factor-I (IGF-I) and their Components on PC-3 Cell Lines

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Authors

P. Kanagaraj ¹, M. R. Vijayababu ¹, S. Sitta-Djody ¹, N. Srinivasan ¹, M. M. Aruldhas ¹, P. Govindarajulu ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALMPGIBMS, University of Madras, Taramani, Chennai - 600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 56-56

Abstract

Insulin like growth factors have been implicated in the regulation of prostate epithelial cell proliferation and induction of prostate cancer. Estrogens play an important role in prostate physiology and disease development. E₂ has been reported to regulate the production of IGFs and IGFBPs in prostate cell lines. Hence, it is attempted to study the effects of E₂ on the production of IGFs and IGFBPs in PC-3 cell line. The PC-3 cells (1x10⁵ cells/ well) were treated with different doses of E₂ (1,10 and 10 nM) for 24 hrs and 48 hrs, the conditioned media were collected and assayed for IGF-I and IGFBP-5. Dose and duration dependent effect of E₂ on IGF-I and IGFBP-5 on PC-3 eel lines will be discussed with available literature.

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• Effects of Quercetin, Vitamin C and E on PCB Exposed Ventral Prostatic Zinc Content of Albino Rats

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Authors

P. Venkataraman ¹, M. Sridhar ¹, S. Dhanammal ¹, P. Murugesan ¹, J. Arunakaran ¹, N. Srinivasan ¹, M. M. Aruldhas ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 85-85

Abstract

Effects of quercetin, vitamin C and E on PCB exposed ventral prostaitc zinc content were studied in adult albino rats, a group of 20 rats were treated with Aroclor 1254 (2 mg/kg bwt/day/IP) for 30 days. Five rats were treated as PCB control. The remaining 15 rats were subdivided into the following subgroups of five animals each. They were given vitamin C (500 mg/kgbwt/day/oral) for 10 days; vitamin E (50 mg/kg bwt/day/oral) for 10 days; quercetin (2 mg/kg bwt/day/oral) for 10 days.

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• Role of RhTGF-β1 on Differentiation and Mineralization of Rat Bone Marrow Stem Cells

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Authors

E. Thirupavai ¹, S. Veni ¹, S. Sitta Djody ¹, R. Ilangovan ¹, M. Balaganesh ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 72-72

Abstract

Bone marrow is a complex tissue, which contains stem cells for haematopoietic and mesenchymal lineage. Among various growth factors that regulate bone remodeling, TGF-bl is the major growth fator, which is synthesized and stored in bone in large amount. But, the exact role of TGF-bl on the differentiation and mineralization of bone marrow stem cells (BMSCs) is still not clear. Hence, the present study is designed to delineate the role of rhTGF-bl on the differentiation and mineralization of rat BMSC in vitro. Bone marrow stem cells were isolated from the femur bones of healthy rats and cultured with osteogenic medium (OM).

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• Role of RhIGF-I on Differentiation and Mineralization of Rat Bone Marrow Stem Cells

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Authors

S. Veni ¹, E. Thirupavai ¹, S. Sitta Djody ¹, R. Ilangovan ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 76-76

Abstract

Bone marrow stem cells (BMSC) develop into pre-osteoblast, mature into osteoblast and attain sensitivity as osteocytes. Among the potential regulators of bone formation, insulin like growth factor-I (IGF-I) occupies an important position because of its ability to stimulate osteoblast proliferation and differentiation. Although, it is well known that osteoblasts are important target cell types, little is known about the effect of rhIGF-I on osteoprogenitors.

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• Effect of 17β-Estradiol on IGFBP-3 Production and Differentiation of SAOS-2 Cells in Vitro

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Authors

M. Balaganesh ¹, R. Ilangovan ¹, S. Sitta Djody ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 81-81

Abstract

Bone formation is a dynamic process, which is regulated by various hormones and local growth factors. Numerous clinical and experimental studies have shown that estrogen deficiency delays the maturation of the skeleton and interferes with the normal growth of the bones.

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• Serum Dihydrotestosterone is a Major Determinant of Bone Mineral Density in Men

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Authors

R. llangovan ¹, M. Balaganesh ¹, S. Sittadjody ¹, R. Sivakumar ¹, M. Sridhar ¹, R. C. Vignesh ¹, B. Ravi Sankar ¹, J. Arunakaran ¹, K. Balasubramanian ¹, M. Michael Aruldhas ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN

Source

Journal of Endocrinology and Reproduction, Vol 10, No 1 (2006), Pagination: 56-58

Abstract

In the present investigation, 100 osteoporotic men with 100 age-matched normal were studied for serum sex steroids, parathyroid hormone (PTH), thyroid hormone (T₃), cytokines and bone turnover markers. Serum dihydrotestosterone (DHT) was significantly decreased in osteoporotic men compared with normal. In osteoporotic men, there was a significant increase in serum interleukin (IL)-lalpha. A marked increase in bone formation marker, serum osteocalcin (OCN) and bone resorption marker, serum tartrate-resistant acid phosphatase (TRAP) reflects high bone turnover in osteoporotic men. In conclusion, the present findings point out an important role of DHT in maintaining BMD in men. A strong positive correlation of serum DHT with BMD offers new perspectives in understanding the role of non-aromatizable androgen in the regulation of bone metabolism in men.

Keywords

BMD, Cytokines, DHT.

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