Journal of Endocrinology and Reproduction

M. R. Vijayababu ¹, P. Kanagaraj ¹, A. Arunkumar ¹, Siva Dhanammal ¹, K. Balasubramanian ¹, N. Srinivasan ¹, M. M. Aruldhas ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Abstract

Recent estimates have placed prostate cancer as the most commonly diagnosed malignancy. It is the fourth most common cancer in men worldwide. Androgen dependent prostate cancer can responds to androgen ablative therapy. However, if the cell contains heterogeneous population of both androgen dependent and androgen independent, the androgen ablative therapy can only responds to androgen dependent cell population but not to independent cancer.

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M. Sridhar ¹, P. Venkataraman ¹, S. Dhanammal ¹, A. Arunkumar ¹, K. Balasubramanian ¹, M. M. Aruldhas ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, IN

Abstract

The present study was conducted to determine the effect of Aroclor 1254 (2 mg/kg bwt/day/IP) for 30 days, induced oxidative stress in prostate of adult albino rats. Additionally antioxidants such as Quercetin (2 mg/kg bwt/day/oral), Vitamin C (500 mg/kg bwt/day/oral) and Vitamin E (50 mg/kg bwt/ day/oral) were administrated to evaluate their therapeutic potency against Aroclor 1254 induced stress for 10 days.

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A. Arunkumar ¹, P. Kanagaraj ¹, M. R. Vijayababu ¹, K. Balsubramanian ¹, M. M. Aruldhas ¹, J. Arunakaran ¹

Affiliations
1 Department of Endocrinology, Dr. ALM PGIBMS, University of Madras, Taramani, Chennai-600 113, IN

Abstract

The cytochrome P450s are hemoproteins, which play critical role in the bioactivation and detoxicfication of a majority of xenobiotic substances such as drugs, environmental pollutants and dietary chemicals, and endogenous compounds such as steroids, fatty acids and prostaglandins. Environmental pollutants are main cause of several carcinogenesis, among these, polychlorinated biphenyls (PCB), are persistant environmental contaminants. Numerous epidemiological and experimental studies imply that garlic can be considered as a dietary anticarcinogenic component.

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