Journal of Endocrinology and Reproduction

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Frequency of Chromosomal Associations in Human Peripheral Blood Lymphocytes Treated with Sodium Fluoride and Arsenic Trioxide and the Possible Protective Effects of Ascorbic Acid


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1 Cell Biology, Cytogenetics and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380009, India
     

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Trace elements like fluoride and arsenic are known to exert their toxic effects if their intake exceeds normal levels. The present in vitro studies on genotoxicity of fluoride and arsenic at dosages of 10μg and 0.001μg/7ml of culture media respectively were carried out to determine their effects on acrocentric and telomeric associations in human lymphocyte cultures.
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  • Frequency of Chromosomal Associations in Human Peripheral Blood Lymphocytes Treated with Sodium Fluoride and Arsenic Trioxide and the Possible Protective Effects of Ascorbic Acid

Abstract Views: 191  |  PDF Views: 0

Authors

S. B. Nair
Cell Biology, Cytogenetics and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380009, India
D. D. Jhala
Cell Biology, Cytogenetics and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380009, India
N. J. Chinoy
Cell Biology, Cytogenetics and Toxicology Unit, DST-FIST Sponsored Department of Zoology, School of Sciences, Gujarat University, Ahmedabad-380009, India

Abstract


Trace elements like fluoride and arsenic are known to exert their toxic effects if their intake exceeds normal levels. The present in vitro studies on genotoxicity of fluoride and arsenic at dosages of 10μg and 0.001μg/7ml of culture media respectively were carried out to determine their effects on acrocentric and telomeric associations in human lymphocyte cultures.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99315