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Gestational Exposure to Chromium Alters the Histoarchitecture of Adult Rat Testis: a Light Microscopic Study


Affiliations
1 Post Graduate Department of Zoology, Voorhees College, Vellore-632001, India
2 Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
3 Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, India
     

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Heavy metals and chemicals are known to cause male infertility. Chromium, an occupational heavy metal pollutant is a wellknown carcinogen with toxic effect on skin, lung and kidney. A few early reports point out the reproductive toxicity of chromium in experimental animals. An extensive study conducted in our laboratory in adult rats and monkeys established that altered prooxidant - antioxidant balance leading to free radical toxicity in the testis as the mechanism underlying the reproductive toxicity of chromium.
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  • Gestational Exposure to Chromium Alters the Histoarchitecture of Adult Rat Testis: a Light Microscopic Study

Abstract Views: 178  |  PDF Views: 0

Authors

P. Sekhar
Post Graduate Department of Zoology, Voorhees College, Vellore-632001, India
S. Subramanian
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
N. S. Venkatesh
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
A. M. J. Sashi
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
N. Kalpana
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
J. Anbalagan
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
G. Vengatesh
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
P. Govindarajulu
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India
M. A. Akbarsha
Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, India
M. M. Aruldhas
Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, India

Abstract


Heavy metals and chemicals are known to cause male infertility. Chromium, an occupational heavy metal pollutant is a wellknown carcinogen with toxic effect on skin, lung and kidney. A few early reports point out the reproductive toxicity of chromium in experimental animals. An extensive study conducted in our laboratory in adult rats and monkeys established that altered prooxidant - antioxidant balance leading to free radical toxicity in the testis as the mechanism underlying the reproductive toxicity of chromium.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F99235