Journal of Endocrinology and Reproduction

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Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro


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1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
     

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Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro.
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  • Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro

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Authors

S. Rengarajan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
R. Sivakumar
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
N. Srinivasan
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
P. Govindarajulu
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
K. Balasubramanian
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India

Abstract


Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro.


DOI: https://doi.org/10.18519/jer%2F2003%2Fv7%2F98961