African Journal of Bacteriology Research

Mohammad Esmaeil Hejazi ¹, Masoud Nazemiyeh ², Fatemeh Seifar ³, Fatemeh Beheshti ⁴

Affiliations
1 Respiratory Diseases, Tuberculosis and Pulmonary Disease Research Center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, IR
2 Respiratory Diseases, Tuberculosis and Lung Disease Research Center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, IR
3 Students’ Research Committee, Tabriz University of Medical Sciences, IR
4 Department of Microbiology, Tabriz University of Medical Sciences, IR

Abstract

Ventilator-associated pneumonia (VAP) is a common infection, developed in intensive care units (ICU). Early diagnosis and appropriate selection of antimicrobial therapy is important to reduce the mortality rate of these patients. Bronchoalveolar lavage (BAL) fluid was obtained from 27 patients, who fulfilled the criteria for ventilator-associated pneumonia. Samples underwent cytological and bacteriological analysis. Pathogens identified from culture of BAL and related antibiotic susceptibility was determined. Ventilator-associated pneumonia was determined in 39.70% of patients in the ICU. Out of enrolled patients, 92.59% had a polymicrobial infection. The most common form of poly microbial infection was with two different bacterial species which were isolated in 81.48% of patients. These isolates revealed a prominent susceptibility to Imipenem, Amikacin, Ciprofloxacin and Ceftazidime. According to the increasing rate of polymicrobial infections and bacterial drug resistance pattern, monotherapy in the treatment of VAP should be avoided. Based on our study, combination therapy with Imipenem or Ceftazidime accompanied by Amikacin or Ciprofloxacin can be recommended.

Keywords

Ventilator-Associated Pneumonia, Polymicrobial, Infection, Bacterial-Resistance, Bronchoalveolar Lavage (BAL).

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