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The world is at present passing through an epidemiological transition with the rate of growth of elderly population exceeding the general population. By the year 2001, India will have the second highest population of elderly in the world with an absolute number of 76 million. The state with highest proportion of elderly in India is Kerala where the elderly constitute approximately 9.79 per cent of total population. Industrialization and urbanization together with the migration of the younger generation abroad has severe impact on the Indian society, with the care of the aged having emerged as a pressing social problem. To an extent, old age homes have filled this need. Kerala has the largest number of homes for the aged. A sharp contrast of environments was perceived to be existing in two types of institutional settings - those with free facilities, which are government aided and those having pay and stay facilities run by private undertakers. The study was an attempt to compare nutritional status of inmates of these two kinds of institutions.

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Antidiabetic Activity of Bioactive Compounds in Pleurotus florida Using Protein Receptors

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Authors

Beena Cherian ¹, Shilpa Jose ²

Affiliations
1 Department of Food Science and Nutrition, Mar Athanasios College for Advanced Studies, (MACFAST) Tiruvalla - 689 101, Kerala, IN
2 St. Teresa’s College, Ernakulam - 682 011, Kerala, IN

Source

The Indian Journal of Nutrition and Dietetics, Vol 59, No 3 (2022), Pagination: 294-299

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder due to the defects of insulin secretion (type 1) and increased cellular resistance to insulin (type 2). Mushrooms were found to be effective for reducing diabetic complications and for decreasing the blood glucose levels. When compared to synthetic drugs, the bioactive compounds isolated from mushrooms seem to be less toxic and free of side effects. The ethanol extracts of <I>Pleurotus florida</I> mushroom was used for the extraction of bioactive compounds. The compounds PFEE-1 to PFEE -14 were screened for drug likeness and molecular properties. For structural molecular biology and computer -assisted drug design, molecular docking is found to be a strong tool. It has been used in an attempt to identify and to expound the mechanism of action of the bioactive compounds in <I>Pleurotus florida</I> with the inhibition of GPCR40, PTPBI, PPAR and DPP4 protein receptor for controlling the blood sugar level. 14 bioactive compounds screened from Pleurotus florida mushroom ethanol extract was docked with the glide software based on the drug-likeness score. Ergosterol was found to be a potent inhibitor of DPP4, GPCR40, PPAR and PTPBI when compared to other bioactive compounds.

Keywords

Molecular Docking, Pleurotus florida, Bioactive Compounds, GPCR40, PTPBI, PPAR and DPP4 Protein Receptor

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