C. Upendra Prasad ¹, S. M. Bose ¹

Affiliations
1 Biochemistry Laboratory, Central Leather Research Institute, Madras-20, IN

Abstract

A few reports are available on the influence of dietary protein on the formation of collagen. The rate of formation of collagen in animal body was found to be decreased due to protein deficiency. Significant reduction in the collagen content of human skins was observed in kwashiorkor. The synthesis of skin collagen was found to decrease considerably in rats fed with low protein or protein free diets, while diets higher in protein than needed did not increase the synthesis of collagen. Recently Vasantha observed a higher hexosamine/collagen ratio in skins of protein calorie deficient rats.

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V. Hanumantha Rao ¹, S. M. Bose ¹

Affiliations
1 Central Leather Research Institute, Madras-20, IN

Abstract

The information with respect to the influence of vitamins on the lathyrogenic changes is meagre. In animals fed on L. Odoratus or treated with B-amino-propionitrite (B A P N), aminoacetonitrile (AAN) or semicarbazide, simultaneous administration of riboflavin, pyridoxine, vitamin B12, choline, ascorbic acid, calciferol or vitamin E has been shown not to inhibit the skeletal manifestations of lathyrism while ascorbic acid has an additive influence on BAPN toxicity.

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