Abstract Views :177 |
PDF Views:0
Authors
Affiliations
1 Department of Cardiology and Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati - 517 507, IN
2 Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati - 517 507, IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 43, No 4 (2006), Pagination: 146-152
Abstract
Mccully first reported association of elevated levels of homocysteine with vascular disease. It was later confirmed by Wilken and Wilken in a case-control study. Development of aggressive, premature vascular disease with homocystinuria led to the hypothesis that mild to moderate elevations in plasma homocysteine might contribute to the development and progression of atherosclerosis in adults. Reduction of cardiovascular risk in homocystinuric patients with dietary methionine restriction and B vitamin supplementation suggested a causal role of higher levels of homocysteine in vascular pathology of homocystinuria.
