International Journal of Medical Sciences https://www.i-scholar.in/index.php/Ijmss <div id="i-scholarabout">International Journal of Medical Sciences is an official publication of the HAS. It features the original research in all branches of Medical Science and other cognate branches of sufficient relevance. The journal publishes three types of articles. i.e. Review/Strategy/Case study (exclusively by in vitat ion from the personalities of eminence), Research paper and Research Note. The manuscripts shou ld be submitted in triplicate with CD in all respect to th e Editor, International Journal of Medical Sciences</div> Hind Agri-Horticultural Society en-US International Journal of Medical Sciences 0974-2654 Association Between Circulating Inflammatory and Anti-Inflammatory Proteins and Risk of Development of Type II Diabetes Mellitusin Indian Obese Children https://www.i-scholar.in/index.php/Ijmss/article/view/179555 <strong>Background and aim:</strong> Anti-inflammatory IL-10, omentin-1 and inflammatory visfatin dysregulation play a role in the development of metabolic syndrome. The objective of this study was to evaluate the association between circulating IL-10, omentin-1 and visfatin concentration and risk of development of type II diabetesin obese with MS children.<strong>Methods:</strong>Total of 220 obese were enrolled in our case-control study. They were divided according to NCEP ATP III criteria into obese without MS (control) and obese with MS (case) based on their BMI-percentile, obese children subdivided into overweight, obese, severally obese on the basis of BMI (percentile). Fasting blood sample was collected to determine biochemical parameters. Serum IL-10, omentin-1and visfatin plasma level was assessed by ELISA kit method. Association of these proteins with biochemical and anthropometric parameters were studied. <strong>Results:</strong> Obese children with MS showed a borderline significant decrease in serum IL-10 levels, Omentin-1 levels however, significantly increased in visfatin levels as compared to without MS obese children. In correlation analysis, we found all the three proteins were significantly corelated with BMI (percentile) but visfatin was also corelated with fasting plasma glucose. <strong>Interpretation and conclusions:</strong> Our study supports the hypothesis that abnormal production of IL- 10, omentin-1 and visfatin may contribute to the development of obesity in children, the correlation between MS and the BMI (percentile) may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI (percentile) for MS is an important factor for establishing an early diagnosis of diabetes.Risk of development of MS may be a diagnostic parameter for obesity-related complications such as Type II DM. Himani Kulshrestha Vani Gupta Sameeksha Mishra Supriya Mishra Shelly Awasthi Abbas Ali Mahdi 2018-10-01 2018-10-01 11 An Apple a Day Keeps Parkinsonism Away https://www.i-scholar.in/index.php/Ijmss/article/view/179556 Parkinson’s disease is a progressive neurological disorder characterized by tremors, rigidity, shuffling gait and hypokinesia. Deficiency of Dopamine in substantia nigra pars compacta is the main cause of the disease. Bromocriptine can be used as an alternate to levodopa because this drug is a direct agonist of striatal dopamine receptors. Therefore, in the present study Bromocriptine served as a standard drug. The main phytoconstituents of Apple fruit are vitamin B<sub>3</sub>, Vitamin B<sub>6</sub>, flavanoids and phenolic compounds such as polyphenol oxidase. Niacin is also reported to improve cognitive as well as motor function by stimulating the production of neurotransmitters. Therefore, anti-parkinsonian potential of Apple juice was investigated in the present study. Apple juice (0.5 ml and 1ml/100g p.o.) reduced the severity of tremors evoked by oxotremorine (0.5 mg/kg, i. p.). Apple juice diminished rigidity induced by Reserpine and restored the mobility impaired by Reserpine (5mg/ kg, i. p.) in rodents. Apple juice appears to produce its anti-parkinsonian activity mediated via enhanced dopamine and nor-epinephrine synthesis, increased cereberal blood flow through stimulation of NO production, antioxidant activity and neuroprotective action. Milind Parle Pankaj Rakha 2018-10-01 2018-10-01 11 Physical Performance of Anemic Adult Females, Udaipur City https://www.i-scholar.in/index.php/Ijmss/article/view/179557 The organ and tissues of human body need a steady supply of oxygen to maintain healthy life. An adequate level of work capacity and physical fitness are important not only from point of view of well being but also of economic productivity, which especially applies to the developing countries. The present study was conducted to find out the physical performance of selected adult females. A baseline survey was conducted on 300 college adult females aged 18-25 years of Udaipur to identify 30 anemic and 10 normal females. The normal group was considered as reference group. An interview schedule was developed to collect the information about the subject and their family. The nutritional status was assessed by anthropometric measurements, Clinical and biochemical examination using standardized techniques. A group of 30 subjects was identified on the basis of hemoglobin level (Below 12g/dl) and clinical signs of anemia. Further a group of 10 normal subjects was also selected on the basis of BMI, hemoglobin and clinical examination. Haematological examination and physical performance of each selected females were assessed. The result revealed that majority of the families i.e. 74 per cent were Hindu. Eighty nine per cent were vegetarian and about 67 per cent of the families were nuclear. The percentage distribution of families as per their socio-economic status revealed that they were from middle class. The anthropometric measurements of 300 females revealed that weight and height were 80.48 and 94.86 per cent of NCHS standard for 18 years old girls, respectively. Mean BMI (kg/m<sup>2</sup>) and weight for height (%) of these females was 18.86 and 103.66 revealing that study group had normal weight for their height. Mean hemoglobin level of adult females was 10.4g/dl. Only 27.67 per cent females were normal by hemoglobin level. Clinical signs of anemia were not common among these females indicating subclinical stage of anemia was present. Reference group had better nutritional status in comparison to anemic group with respect to all measured parameters. It was observed that reference group subjects were in superior oxidative category with 99.76 per cent physical fitness. Mean physical fitness and endurance capacity of anemic group was 77.37 per cent and 256.23 steps, respectively. These results clearly depicts that iron deficiency had negative impact on iron status and which in turn on physical performance and work capacity. Monica Dungarwal Shashi Jain 2018-10-01 2018-10-01 11 Product Development for Boosting Immune System https://www.i-scholar.in/index.php/Ijmss/article/view/179558 The objective of present investigation was to development products for boosting immune systemusing honey, ginger oats and conducting sensory evaluation of developed products to know the accceptability.The immune system is amazingly complex. It can recognize and remember millions of different enemies and it can produce secretions and cells to match up with and wipe out each one of them. The secret to its success is an elaborate and dynamic communications network. Millions and millions of cells, organized into sets and subsets, gather like clouds of bees swarming around a hive and pass information back and forth.Once immune cells receive the alarm, they undergo tactical changes and begin to produce powerful chemicals.These substances allow the cells to regulate their own growth and behaviour, enlist their fellows and direct new recruits to trouble spots. Developed products for boosting immune system were ginger candy, oats tikki, oats pancake,oats honey cookies, immune boosting <em>Laddoo</em>. The organoleptic evaluation of products was done by panel members using (9-point hedonic rating scale). The result showed that ginger candy and oats tikki (T<sub>1</sub>) were best in all treatment in case of all sensory attributes. The average for overall acceptability of experimental (T<sub>1</sub>) ginger candy and oats tikki was 10.0 and 9.1, respectively. Developed products were accepted by panellist . Archana Singh Reshu Singh 2018-10-01 2018-10-01 11 Effect of Supplementation of Cinnamon (<i>Cinnamomum zeylanicum</i>) Powder on Diabetics https://www.i-scholar.in/index.php/Ijmss/article/view/179559 The present study was designed to determine the effect of supplementation of cinnamon powder on blood glucose level of selected diabetic patients. The cinnamaldehyde an active component in cinnamon have health protecting effect. Cinnamon has insulin like activity and it contains an active ingredient water soluble polyphenol compound MHCP (methyl hydroxi chalcon polymer). It initiates insulin, triggers its receptors and works synergistically with insulin cells. The investigation was conducted in two phases. In the first phase of experiment, thirty Type II diabetic subjects were selected by purposive sampling technique in Parbhani city. They were personally interviewed with the help of pre-tested questionnaire to elicit the information regarding socio-economic background, health status and food and nutrient intake. In the second phase of experiment, they were divided into two equal groups experimental and control group. The experimental group was supplemented by three capsules (containing 500 mg of cinnamon powder each) daily for 60 days. No supplementation was given to control group. The fasting and post prandial blood sugar level of all the selected thirty subjects, both experimental and control group was recorded initially, after 30 and 60 days. Anthropometric measurements were taken before and after the experiment. Nutrient content of cinnamon powder was analyzed. The collected data was analyzed statistically and it was concluded that the consumption of 1.5 g of cinnamon powder continuously for 60 days has positive effect in diabetic subjects. Reshma Uddhavrao Malleshe Farooqui Hafeez Farzana 2018-10-01 2018-10-01 11