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Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets


Affiliations
1 Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
2 L'UNAM, University of Angers, GEPEA UMR-CNRS 6144, 2 boulevard Lavoisier, 49045 Angers, France
3 L'UNAM, University of Angers, GEIHP EA 3142, Institut de Biologie en Sante-IRIS, CHU, 4 rue Larrey, 49933 Angers, France
4 Universite de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, France
 

Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modifiedwith coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersiveX-ray spectroscopy (SEMEDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N = 3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.
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  • Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets

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Authors

Serge Foukmeniok Mbokou
Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
Maxime Pontie
L'UNAM, University of Angers, GEPEA UMR-CNRS 6144, 2 boulevard Lavoisier, 49045 Angers, France
Jean-Philippe Bouchara
L'UNAM, University of Angers, GEIHP EA 3142, Institut de Biologie en Sante-IRIS, CHU, 4 rue Larrey, 49933 Angers, France
Francis Merlin Melataguia Tchieno
Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
Evangeline Njanja
Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon
Assad Mogni
Universite de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, France
Pierre Yves Pontalier
Universite de Toulouse, INP-ENSIACET, Laboratoire de Chimie Agro-Industrielle (LCA), 31030 Toulouse, France
Ignas Kenfack Tonle
Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon

Abstract


Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modifiedwith coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersiveX-ray spectroscopy (SEMEDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N = 3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.