A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Roy, Soumen
- Fraxinus Excelsior and Vitamin E Combination for NAFLD (FEVEN)
Authors
1 Medical Affairs Department, Macleods Pharmaceuticals Ltd.
Source
The Indian Practitioner, Vol 71, No 11 (2018), Pagination: 22-29Abstract
Objective: The combination of Vitamin E 400 IU soft gelatin capsule and Fraxinus excelsior500 mg soft gelatin capsules (Ensules+) were evaluated for safety and efficacy as compared to Vitamin E 400 IU soft gelatin capsules in patients with NAFLD.Material and Methods: The prospective, open-label, comparative, randomized, single centre clinical trial was conducted by Macleods Pharmaceuticals in collaboration with Muktai Hospital, Nashik. Total of 24 NAFLD patients were divided into 2 groups and received either Vitamin E (400 IU) soft gelatin capsule or Ensules+ (combination of Vitamin E 400 IU and Fraxinus excelsior 500mg) soft gelatin capsules BID for 8 weeks. The Grades of Liver steatosis after 8 weeks, liver function test (AST, ALT, ALP, bilirubin levels) and serum lipid profile (Tg, Tc, HDL, LDL) was evaluated at the end of the study.
Result: Nonalcoholic fatty liver disease (NAFLD) patients with Vitamin E and Ensules+ therapy BID for 8 weeks revealed no significant difference in the physical parameters like mean body temperature, pulse rate and blood pressure from baseline to end of the study.
Significant improvement in lipid profile and liver function parameters were observed in both the groups at the end of the study as compared to the baseline. The % improvement in Tc and LDL (3.27 % and 4.93% respectively) from baseline were significant in Ensules+ group (B) as compared to Vitamin E group (A) (1.10% and 1.13 % respectively), also HDL levels were significantly elevated (1.34 %) in Ensules+ group.
Percentage improvement in liver function parameters in group A patients treated with Ensules+ Capsule had higher AST (53.64%), ALT (59.53%) ALP (38.43%) and Bilirubin levels (56.54%) as compared to group B patients treated with vitamin E capsules.
5 Patients treated with Ensules+ (combination of Vitamin E 400IU and Fraxinus excelsior 500mg) soft gelatin capsules) showed significant regression with the fatty liver disease at the end of the study.
Conclusion: Combination of Vitamin E and Fraxinus excelsior (Ensules+) capsule were found to be better in improving the lipid profile and liver function parameters in patients with NAFLD. To the best of our knowledge, this is the first study which compares the combination with Vitamin E capsule and found to be more effective in treating patients with NAFLD.
Keywords
NAFLD, NASH, Vitamin E, Fraxinus Excelsior, Ensules+
References
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- A Review of Digestive Enzyme and Probiotic Supplementation for Functional Gastrointestinal Disorders
Authors
1 Yatharth Super Speciality Hospital, Greater Noida, IN
2 Senior Consultant, Internal Medicine, Bhopal, IN
3 Sunflower Medical Centre, Lucknow, IN
4 Paras Hospitals, Gurugram, IN
5 Medical Affairs, Macleods Pharmaceuticals Ltd., Mumbai, IN
6 Centre for Clinical Research and Practice & Research Centre for Diabetes, Hypertension and Obesity, Samastipur, IN
Source
The Indian Practitioner, Vol 73, No 3 (2020), Pagination: 35-39Abstract
Functional gastrointestinal disorders (FGIDs) also known as disorders of gut-brain interaction are chronic, recurrent disorders with no identifiable underlying pathology. The FGID with upper abdominal pain and discomfort is the hallmark feature of functional dyspepsia. Around 11-30 % prevalence of functional dyspepsia is reported worldwide. One of the unique features of functional dyspepsia is transient deficiency of digestive enzymes in the system. Digestive enzymes are produced and secreted by the gastrointestinal system to break down fats, proteins, and carbohydrates, to accomplish digestion and, afterwards, the absorption of nutrients. Supplementation with digestive enzymes could provide management of disorders caused by impaired digestive function. Various formulations of enzyme supplementation are available commercially in the market, and are currently used in clinical practice for the management of several digestive diseases. Probiotics have multi-faceted role, helping to restore the gut microbiota.
This review elaborates the potential of multi digestive enzymes along with probiotics in the management of digestive diseases and dyspepsia.
Keywords
Digestive enzyme, Probiotics, Functional Dyspepsia, Indigestion.References
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