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Luliconazole: Paradigm Shift in the Management of Topical Tinea Infections
Luliconazole is an imidazole topical antifungal agent with a unique structure. Pre-clinical studies have demonstrated excellent activity against dermatophytes. Although luliconazole belongs to the azole group, it has strong antifungal activities against Trichophyton spp. This may be attributed to a combination of strong in vitro antifungal activity and favourable pharmaco kinetic properties in the skin. Clinical trials have demonstrated its superiority over placebo in dermatophytosis, and performed better than terbinafine. The frequency of application (once daily) and duration of treatment (one week for tinea corporis/cruris and 2 weeks for interdigital tinea pedis) was favourable when compared to other topical regimens in treating tinea pedis. Such regimens include 2–4 weeks of twice-daily treatment with econazole, up to 4 weeks of twice-daily treatment with sertaconazole, 1–2 weeks of twice-daily treatment with terbinafine, 4 weeks of once-daily application of naftifine and 4–6 weeks of once-daily treatment with amorolfine. Luliconazole 1% cream was approved in Japan in 2005 for the treatment of tinea infections. Recently, the US Food and Drug Administration (USFDA) approved luliconazole for interdigital tinea pedis, tinea cruris, and tinea corporis treatment. Topical luliconazole has a favourable safety profile, with mild application-site reactions reported occasionally.
Luliconazole, Tinea pedis, Tinea corporis, Tinea cruris, once a daily
- Sahoo AK, Mahajan R. Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian Dermatol Online J 2016; 7:77-86
- Khanna D, Bharti S. Luliconazole for the treatment of fungal infections: an evidence-based review. Core Evidence 2014:9 113–124.
- LUZU label. Prescribing information http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204153s000lbl.pdf assessed on 30th December, 2018.
- Brunton LL editor. Anti-fungal agents. In: Goodman & Gilman’s - The Pharmacological Basis of Therapeutics. 12th edition. The McGraw-Hill publication. Newyork.2011.
- Tripathi KD editor. Anti-fungal drugs. In: Essentials of Medical Pharmacology, 7th edition. Jaypee Brothers Medical Publishers (P) Ltd. New Delhi.2013
- Koga H et al. In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses. J Infect Chemother (2006) 12:163–165.
- Koga H et al. In vitro antifungal activities of luliconazole, a new topical imidazole. Medical Mycology 2009; 47: 640-647.
- Gupta AK, Daigle D. A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections. Infection and Drug Resistance 2016; 9: 1–6.
- Feng X et al. Efficacy and tolerability of luliconazole cream 1% for dermatophytoses: A Meta-analysis. Journal of Dermatology 2014; 41: 779–782.
- Vidhya Lakshmi CP, Bengalorkar GM, Shiva Kumar V. Clinical efficacy of topical terbinafine versus topical luliconazole in treatment of tinea corporis/tinea cruris patients. British Journal of Pharmaceutical Research 2013; 3(4): 1001-1014.
- Jerajani H, Janaki C, Kumar S, Phiske M. Comparative assessment of the efficacy and safety of sertaconazole (2%) cream versus terbinafine cream (1%) versus luliconazole (1%) cream in patients with dermatophytoses: a pilot study. Indian J Dermatol.2013; 58:34–38.
- Selvan A, Girisha G, Vijaybhaskar, Suthakaran R. Comparative evaluation of newer topical anti-fungal agents in the treatment of superficial fungal infections (tinea or dermatophytic). Int Res J Pharm 2013; 4:224–228.
- Jones TM, Jarratt MT, Mendez-Moguel I et al. A randomized, multicenter, double-blind, vehicle-controlled study evaluating the efficacy and safety of luliconazole cream1% once daily for 7 days in patients aged ≥ 12 years with tinea cruris. J Drugs Dermatol.2014; 13:32–38
- Jarratt M et al. Luliconazole for the treatment of interdigital tinea pedis: A doubleblind, Vehiclecontrolled study. Cutis 2013;91 (4):20310
- Gold MH, Olin JS. Once-daily luliconazole cream 1% for the treatment of interdigital tinea pedis. Expert Review of Antiinfective Therapy 2015:1-17.
- Watanabe S et al. A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis. Mycoses 2006; 49: 236–241.
- Watanabe S, Takahashi H, Nishikawa T et al. Dose-finding comparative study of 2weeks of luliconazole cream treatment for tinea pedis – comparison between three groups (1%, 0.5%, 0.1%) by a multicenter randomised double-blind study. Mycoses 2007; 50: 35–40.
- Jarratt M et al. Efficacy and safety of once-daily luliconazole 1% cream in patients ≥12 years of age with interdigital tinea pedis: a phase 3, randomized, double-blind, vehicle-controlled study. J Drugs Dermatol. 2014; 13(7):838-46.
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