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High Fructose Intake, HCFS and Metabolic Syndrome-Should We Be On Guard?


Affiliations
1 Sir Vithaldas Thackersey College of Home Science (Autonomous), SNDT Women’s University, Mumbai, India
2 Nirmala Niketan College of Home Science, Mumbai University, India
     

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The prevalence of Non-Communicable Diseases (NCDs) is increasing universally at an alarming rate. NCDs are estimated to account for 60% of total deaths. Globally, type 2 diabetes mellitus is prevalent in epidemic proportions. According to International Diabetes Federation (IDF), 366 million adults were affected by the disease in 2011, and this figure is likely to escalate to 552 million by 2030. India, like many other developing countries, faces the triple burden of malnutrition from the persisting array of communicable diseases, lifestyle related NCDs and micronutrient deficiencies. This cuts across all age groups and socioeconomic strata.
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  • Hosseini-Esfahani F, Hosseinpanah F, Azizi F, Hosseinpour-Niazi S, Bahadoran Z, Mirmiran P: Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study [electronic resource]. Nutrition & Metabolism 2011, 8.

  • Tappy L, Lê K-A: Metabolic effects of fructose and the worldwide increase in obesity. Physiological Reviews 2010a, 90:23-46.

  • Malik VS, Hu FB. Sweeteners and Risk of Obesity and Type 2 Diabetes: The Role of Sugar- Sweetened Beverages. Curr Diab Rep (2012) 12:195-203 DOI 10.1007/s11892-0120259-6.

  • Hanover LM, White JS. Manufacturing, composition and applications of fructose. Am J Clin Nutr. 1993;58:724S–32S.

  • Vuilleumier S. Worldwide production of high-fructose syrup and crystalline fructose. Am J Clin Nutr.

  • ;58:733S–6S.

  • Park YK, Yetley EA. Intake and food sources of fructose in the United States. Am J Clin Nutr. 1993;58:737S–47S.

  • Sigman-Grant M, Keast DR. Addendum to Am J ClinNutr 1995;62 (Suppl):178S–194S. Am J Clin Nutr. 1997;65:1572– 4.

  • Bialostosky K, Wright JD, Kennedy-Stephenson J, McDowell M, Johnson CL. Dietary intake of macronutrients, micronutrients and other dietary constituents: United States 1988–94. National Center for Health Statistics. Vital Health Stat 11. 2002;245:1–58.

  • Popkin BM, Nielsen SJ. The sweetening of the world’s diet. Obes Res. 2003;11:1325–32.

  • Chan T-F, Lin W-T, Chen Y-L, Huang H-L, Yang W-Z, Lee C-C, Chen M-H, Wang T-N, Huang M-C, et al.

  • Elevate Serum Triglyceride and Retinal-Binding Protein 4 Levels Associated with Fructose-Sweetened Beverages in Adolescents. PLOS. 2014;9:1-9.

  • Stanhope, K.L.; Schwarz, J.M.; Keim, N.L.; Griffen, S.C.; Bremer, A.A.; Graham, J.L.; Hatcher, B.; Cox, C.L.; Dyachenko, A.; Zhang, W.; et al. Consuming fructosesweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Investig. 2009, 119, 1322–1334.

  • Jensen, M.D.; Haymond, M.W.; Rizza, R.A.; Cryer, P.E.; Miles, J.M. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Investig. 1989, 83, 1168–1173.

  • Ma J, Sloan M, Fox CS, Hoffmann U, Smith CE, Saltzman E, Rogers GT, Jacques PF, McKeown NM Sugar-sweetened beverage consumption is associated with abdominal fat partitioning in healthy adults. J Nutr 2014;144:1283–90.

  • Sievenpiper, J.L.; de Souza, R.J.; Mirrahimi, A.; Yu, M.E.; Carleton, A.J.; Beyene, J.; Chiavaroli, L.; Di Buono, M.; Jenkins, A.L.; Leiter, L.A.; et al. Effect of fructose on body weight in controlled feeding trials: A systematic review and meta-analysis. Ann. Intern. Med. 2012, 156, 291–304.

  • Perry, R.J.; Camporez, J.P.; Kursawe, R.; Titchenell, P.M.; Zhang, D.; Perry, C.J.; Jurczak, M.J.; Abudukadier, A.; Han, M.S.; Zhang, X.M.; et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 2015, 160, 745–758.

  • David Wang, D.; Sievenpiper, J.L.; de Souza, R.J.; Cozma, A.I.; Chiavaroli, L.; Ha, V.; Mirrahimi, A.; Carleton, A.J.; Di Buono, M.; Jenkins, A.L.; et al. Effect of fructose on postprandial triglycerides: A systematic review and meta-analysis of controlled feeding trials. Atherosclerosis 2014, 232, 125–133.

  • Agebratt, C.; Strom, E.; Romu, T.; Dahlqvist-Leinhard, O.; Borga, M.; Leandersson, P.; Nystrom, F.H. A randomized study of the effects of additional fruit and nuts consumption on hepatic fat content, cardiovascular risk factors and basal metabolic rate. PLoS ONE 2016, 11, e0147149.

  • Marriott,B.P.; Cole,N.; Lee, E. National estimates of dietary fructose intake increased from1977 to 2004 in the United States. J. Nutr. 2009, 139, 1228s–1235s.

  • Chung,M.; Ma,J.; Patel,K.; Berger,S.; Lau,J.; Lichtenstein, A.H. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: A systematic review and meta-analysis. Am. J. Clin. Nutr. 2014, 100, 833–849.

  • TeMorenga,L.; Mallard,S.; Mann, J. Dietary sugars and body weight: Systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ 2012, 346, e7492.

  • Chiu,S.; Sievenpiper,J.L.; deSouza,R.J.; Cozma,A.I.; Mirrahimi,A.; Carleton,A.J.; Ha,V.; DiBuono,M.; Jenkins, A.L.; Leiter, L.A.; et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of controlled feeding trials. Eur. J. Clin. Nutr. 2014, 68, 416–423.

  • Volynets,V.; Machann,J.; Kuper,M.A.; Maier,I.B.; Spruss,A.; Konigsrainer,A.; Bischoff,S.C.; Bergheim,I. A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): A pilot study. Eur. J. Nutr. 2013, 52, 527–535.

  • Schwarz,J.M.; Noworolski,S.M.; ErkinCakmak,A.; Korn,N.J.; Wen,M.J.; Tai,V.W.; Jones,G.M.; Palii,S.P.; Velasco-Alin, M.; Pan, K.; et al. Effects of dietary fructose restriction on liver fat, de novo lipogenesis, and insulin kinetics in children with obesity. Gastroenterology 2017.

  • Kelishadi R, Mansourian M, Heidari-Beni M. Association of fructose consumption and components of metabolic syndrome in human studies: A systematic review and meta-analysis. Nutrition. 2014;30:503–10.

  • Bantle, J. P. Dietary fructose and metabolic syndrome and diabetes. J. Nutr.139, 1263S–1268S (2009).

  • Shin JY, Kim JY, Kang HT, Han KH, Shim JY. Effect of fruits and vegetables on metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Int J Food Sci Nutr. 2015;66(4):416–25.PubMed.

  • Dushay JR, Toschi E, Mitten EK, Fisher FM, Herman MA, Maratos-Flier E.Fructose ingestion acutely stimulates circulating FGF21 levels in humans. MolMetab. 2014 Oct 8;4(1):51-7. doi: 10.1016/j.molmet.2014.09.008. eCollection 2015 Jan.


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  • High Fructose Intake, HCFS and Metabolic Syndrome-Should We Be On Guard?

Abstract Views: 234  |  PDF Views: 4

Authors

Jagmeet Madan
Sir Vithaldas Thackersey College of Home Science (Autonomous), SNDT Women’s University, Mumbai, India
Chandni Chopra
Nirmala Niketan College of Home Science, Mumbai University, India

Abstract


The prevalence of Non-Communicable Diseases (NCDs) is increasing universally at an alarming rate. NCDs are estimated to account for 60% of total deaths. Globally, type 2 diabetes mellitus is prevalent in epidemic proportions. According to International Diabetes Federation (IDF), 366 million adults were affected by the disease in 2011, and this figure is likely to escalate to 552 million by 2030. India, like many other developing countries, faces the triple burden of malnutrition from the persisting array of communicable diseases, lifestyle related NCDs and micronutrient deficiencies. This cuts across all age groups and socioeconomic strata.

References