The Indian Practitioner

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Electrolyte Profile of Dengue Infected Patients:An Observational Study from a Tertiary Care Centre in Rajasthan


Affiliations
1 J.L.N. Medical College, Ajmer (Rajasthan), India
     

   Subscribe/Renew Journal


Dengue infection is one of the most common and potentially fatal mosquito-borne infections in tropical and subtropical countries. No specific treatment is available and the mainstay of treatment is careful fluid management, specific organ support and correction of metabolic and electrolyte derangement. The aim of our study was to evaluate electrolyte disturbances in patients with dengue infection in our hospital. In this study we included total 60 clinically diagnosed and serologically confirmed age and sex matched dengue infected cases. Serum electrolytes [sodium, potassium&calcium] were measured using semi- auto analyser. The mean age of the study group was 32 years. 65% of the patients were males and 35% were females. On analysis it was found that the amount of calcium decreased significantly (p < 0.03) in the study group as compared to control group while value of sodium (p < 0.6) and potassium (p < 0.5) reduced non-significantly. Hence timely diagnosis and supportive therapy of these electrolyte disturbances can reduce associated morbidity and mortality in dengue patients.

Keywords

Dengue, Electrolyte Disturbance, Hypocalcaemia.
Subscription Login to verify subscription
User
Notifications
Font Size


  • L. Castilla-Guerra, M. C. Fernandez-Moreno, J. M. Lopez-Chozas and R. Fernandez-Bolanos. Electrolytes Disturbances and Seizures. Epilepsia, 2006; 47:1990–1998.

  • Wichmann D, Kularatne S, Ehrhardt S, Wijesinghe S, Brattig NW, Abel W, et al. Cardiac involvement in dengue virus infections during the 2004/2005 dengue fever season in Sri Lanka. Southeast Asian J Trop Med Public Health. 2009;40:727–30.

  • Bunnag T, Kalayanarooj S. J Med Assoc Thai. Vol. 94. Bangkok, Thailand: 2011. Dengue shock syndrome at the emergency room of Queen Sirikit National Institute of Child Health; pp. S57–63.

  • Uddin KN, Musa AKM, Haque WMM, Sarker RSC, Ahmed AKMS. A follow up on biochemical parameters in dengue patients attending BIRDEM hospital. Ibrahim Med Coll J. 2008;2:25–7.

  • Kapoor S, Singh A. Hypocalcemic tetany: An infrequently recognized association with acute dengue infection. Indian J Pediatr. 2012;79:1673.

  • Constantine GR, Rajapakse S, Ranasinghe P, Parththipan B, Wijewickrama A, Jayawardana P Hypocalcemia is associated with disease severity in patients with dengue J Infect Dev Ctries. 2014 ;12:1205-9

  • Bielefeldt-Ohmann H, Meyer M, Fitzpatrick DR, Mackenzie JS. Dengue virus binding to human leukocyte cell lines: Receptor usage differs between cell types and virus strains. Virus Res. 2001;73:81–9.

  • Dhawan R, Chaturvedi UC, Khanna M, Mathur A,Tekwani BL, Pandey VC. Obligatory role of Ca2+in the cytotoxic activity of dengue virus-induced cytotoxin. Int J Exp Pathol. 1991;72:31–9

  • Khanna M, Chaturvedi UC, Dhawan R, Tekwani BL, Pandey VC. Presence of Ca 2+ is obligatory for the cytotoxic activity of dengue virus-induced cytotoxic factor. Immunology. 1991;72:73–8

  • Chaturvedi P, Saxena V, Dhawan R, Chaturvedi UC. Role of calcium in induction of dengue virus-specific helper T cells. Indian J Exp Biol. 1995;33:809–15

  • Baton, S.M , Oncog A . A pilot study on the level of serum calcium in pediatric patients with dengue fever and dengue shock syndrome. Pediatric critical care medicine: 2014 ;15: suppl - p 153

  • Cabrera-Cortina JI, Sanchez-Valdez E, Cedas-DeLezama D, Ramírez-González MD. Oral calcium administration attenuates thrombocytopenia in patients with dengue fever. Report of a pilot study. Proc West Pharmacol Soc. 2008;51:38–41.


Abstract Views: 168

PDF Views: 1




  • Electrolyte Profile of Dengue Infected Patients:An Observational Study from a Tertiary Care Centre in Rajasthan

Abstract Views: 168  |  PDF Views: 1

Authors

M. Maheshwari
J.L.N. Medical College, Ajmer (Rajasthan), India
R. Bansal
J.L.N. Medical College, Ajmer (Rajasthan), India
S. Gupta
J.L.N. Medical College, Ajmer (Rajasthan), India

Abstract


Dengue infection is one of the most common and potentially fatal mosquito-borne infections in tropical and subtropical countries. No specific treatment is available and the mainstay of treatment is careful fluid management, specific organ support and correction of metabolic and electrolyte derangement. The aim of our study was to evaluate electrolyte disturbances in patients with dengue infection in our hospital. In this study we included total 60 clinically diagnosed and serologically confirmed age and sex matched dengue infected cases. Serum electrolytes [sodium, potassium&calcium] were measured using semi- auto analyser. The mean age of the study group was 32 years. 65% of the patients were males and 35% were females. On analysis it was found that the amount of calcium decreased significantly (p < 0.03) in the study group as compared to control group while value of sodium (p < 0.6) and potassium (p < 0.5) reduced non-significantly. Hence timely diagnosis and supportive therapy of these electrolyte disturbances can reduce associated morbidity and mortality in dengue patients.

Keywords


Dengue, Electrolyte Disturbance, Hypocalcaemia.

References