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Shrivastava, N.
- A Study of Lipid Profile and Antioxidant Capacity in Pregnancy Induced Hypertension
Authors
1 Department of Obstetrics and Gynaecology, M.G.M. Medical College, Indore, Madhya Pradesh, IN
Source
The Indian Practitioner, Vol 69, No 1 (2016), Pagination: 30-35Abstract
Objectives: (1) To evaluate the relationship between different fractions of serum lipid and subtypes of PIH. (2) Assessing consumption of antioxidants due to increased lipid peroxidation in pregnancy induced hypertension that may contribute to atherogenicity and pathogenesis in pregnancy induced hypertension.
Design and setting: This was a prospective study, conducted between October 2012 and December 2012 in the department of obstetrics and gynaecology- MGM Medical College and associated M.Y. Hospital.
Method and material: This study was carried out on 250 patients, divided in four groups: (a) gestational hypertension, (b) pre-eclampsia, (c) eclampsia and (d) normotensive pregnant women (controls). Blood samples were collected from all patients and analysed enzymatically for serum cholesterol, triglycerides, and VLDL, LDL, HDL and spectrophotometric antioxidant capacity.
Statistical analysis used: Statistical analysis done with SPSS-17 programme, variables were described first than compared between three groups using ANNOVA test. A p-value < 0 .05 was considered significant.
Results: In our study, level of serum cholesterol, triglyceride, low density lipoproteins and very low density lipoproteins were significantly higher in all subgroups of PIH as compared to normotensive pregnant patients. Antioxidant capacity was also significantly low in PIH patients compared to normotensive pregnant patients.
Conclusion: Significant difference in the level of lipids and antioxidant capacity between PIH and normotensive pregnant patients suggests that lipid metabolism and lipid peroxidation play key role in pathophysiology of PIH.
Keywords
Pregnancy Induced Hypertension (PIH), VLDL (Very Low Density Lipoproteins), LDL (Low Density Lipoproteins), HDL (High Density Lipoproteins), Antioxidant Capacity.
- Correlation of Histopathological and Anatomical Changes in Placenta with Intrauterine Growth Restriction
Authors
1 Dept. of Obs and Gynae, MGM Medical College, Indore, Madhya Pradesh, IN
Source
The Indian Practitioner, Vol 69, No 5 (2016), Pagination: 30-37Abstract
Background: Placenta is a vital organ for maintaining pregnancy and promoting normal growth by transfer of essential nutrients between foetus and mother. Any morphological alteration of the placenta affects the growth of foetus leading to intrauterine growth restriction (IUGR). The purpose of this study was to find out morphological and histopathological changes of placenta and to evaluate correlation of IUGR and placental histology.Material and Methods: This study included 200 pregnant patients whose foetuses had intrauterine growth restriction and 200 patients with normal foetal growth. Gross and histopathological features of placentas of both groups were studied, analysed by student's t test and compared with chi square test. p values of < 0.05 were considered significant.
Results: Gross features, weight, thickness and calcification in study group show significant increase in value (p < 0.05) compared to control group and histopathology of placenta in study group also shows significant increase in syncytial knots formation, cytotrophoblastic proliferation, stromal fibrosis and calcification as compared to control group.
Conclusion: To conclude, whatever may be the cause of IUGR, these morphological and histopathological changes lead to decrease blood to the placenta and this restriction of blood flow ultimately causes IUGR in the foetus.
Keywords
Placenta, IUGR, Syncytial Knot, Cytotrophoblastic Proliferation.References
- Kaur P, Kaushal S, Singh K, Sharma A. Placental weight, birth weight and fetal outcome in preeclampsia and normotensive pregnancy. IJPAES. 2013;3(4):30-34
- Arias F. Practical guide to high risk pregnancy and delivery. 2008;3/e :99-100
- Dhabhai P, Gupta G. Placental weight and surface area in iugr cases. Innovative Journal of Medical and Health Sciences. 2014;4(6):198-200.
- Aherne W, Dunnill MS. Quantitative aspects of placental structure. J Pathol Bacteriol. 1966; 91(1):123-39
- Cetin I, Alvino G.Intrauterine Growth Restriction: Implications for placental metabolism and transport-A review Placenta.2009;(30):77-82
- Althshuler G, Russell P, Ermochilla R. The placental pathology of small for gestational age infants. Am J Obs Gynecol. 1975;121:351-59
- Nigam JS, Mishra V, Singh P, Singh A, Chauhan S, Thakur B.Histological study of placenta in low birth baby in india.2014;4(8):79-83.
- Hemlata M, Pani Kumar M, Jankai M, Dudala SR. Histopathological evaluation of placentas in IUGR pregnancies. Asian Pac J. Health Sci. 2014;1(4):566-569.
- Kotgirwar S, Ambiye M,Athavale S,Gupta V, Trivedi S. Study of Gross and Histological features of placenta in intrauterine growth retardation. J. Anat. Soc. India2011; 60(1) :37-40
- Biswas S, Ghosh SK. Gross morphological changes of placentas associated with intrauterine growth restriction of fetuses: a case-control study. Early Human Develop. 2008;84(6):357-62.
- Meeejus G. Influence of placental size and gross abnormalities on intrauterinegrowth retardation in high-risk pregnancies. Acta Medical lituanica. 2005;12 (2):14–19 12. Barker DPJ. Fetal growth restriction: A workshop report. Clin Sci. 1998:95;115-128.
- Correlation of Histopathological and Anatomical Changes in Placenta of Intrauterine Growth Restriction (I.U.G.R)
Authors
1 Dept of Obstetrics And Gynaecology, M.G.M. Medical College, Indore, Madhya Pradesh, IN
2 Department of Obstetrics And Gynaecology, M.G.M. Medical College, Indore, Madhya Pradesh, IN
Source
The Indian Practitioner, Vol 69, No 8 (2016), Pagination: 19-24Abstract
Background: Placenta is a vital organ for maintaining pregnancy and promoting normal growth by transfer of essential nutrients between fetus and mother. Any morphological alteration of placenta affects the growth of fetus leads to intrauterine growth restriction.
Material and methods: This study was conducted in 200 patients with IUGR and 200 normal patients. Gross and histopathological features of placentas of both groups are studied, analysed by student t test and compared with chi square test. p value<.05 was considered significant.
Results: Gross features weight, thickness and calcification in study show significant increase in value(p<0.05) compared to control group and histopathology of placenta also show significant increase in syncytial knots formation, cytotrophoblastic proliferation, stromal fibrosis and calcification in comparison to control group.
Conclusion: To conclude these morphological and histopathological findings of placenta are the etiological bases of I.U.G.R.
Keywords
Placenta, I.U.G.R., Syncytial Knot, Cytotrophoblastic Proliferation.References
- Prabhjot Kaur, Subhash Kaushal, Kuljit Singh and Ashish Sharma. Placental weight, birth weight and fetal outcome in preeclampsia and normotensive pregnancy. International journal of plants animal and environmental sciences Oct-Dec2013; 3(4):30-34
- Fernando Arias. Practical guide to high risk pregnancy and delivary. 2008;3/e :99-100
- Pooja Dhabha, Ghanshyam Gupta. Placental weight and surface area in iugr cases. Innovative journal of medical and health sciences. nov-dec 2014; 4-6: 198200.
- Aherne W, Dunnill MS. Quantitative aspects of placental structure. J Pathol Bacteriol 1966 Jan;91(1):123-39
- Cetin I, Alvino G. Intrauterine Growth Restriction: Implications for placental metabolism and transport-A review Placenta.2009;(30):77-82
- Althshuler G, Russell P, Ermochilla R.The placental pathology of small for gestational age infants. Am J obstet. Gynecol.1975; 121: 351-59
- J S Nigam, V Mishra, P Singh, P A singh, S Chauhan, B Thakur. Histological study of placenta in low birth baby in india.2014;4(8):79-83.
- Hemlata M, Pani Kumar M, Jankai M, Shankar Raddy Dudala. histopathological evaluation of placentas in IUGR pregnancies. Asian Pac J. Health Sci 2014;1(4):566-569.
- S Kotgirwar, M Ambiye, S Athavale,V Gupta, S Trivedi. Study of Gross and Histological features of placenta in intrauterine growth retardation. J. Anat. Soc. India2011; 60(1) :37-40
- Biswas S, Ghosh SK. Gross morphological changes of placentas associated with intrauterine growth restriction of fetuses: a case-control study. Early Human Develop 2008 jun; 84(6): 357-62.
- Gediminas Meèëjus. Influence of placental size and gross abnormalities on intrauterine growth retardation in high-risk pregnancies. Acta medica lituanica. 2005; 12 (2): p. 14–19
- Barker DPJ. Fetal growth restriction: A workshop report. Clin sci 1998: 95; 115-128