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Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2h)-One) [(pyridin-2-Yl)ethylidene]hydrazone


Affiliations
1 Department of Chemistry, University of Buea, Buea, Cameroon
2 Department of Biomedical Sciences, University of Bamenda, Bambili, Cameroon
 

The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.

Keywords

Hydralazine Hydrochloride, Schiff Bases, Anti-Onchocercal Activity.
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  • Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2h)-One) [(pyridin-2-Yl)ethylidene]hydrazone

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Authors

Joseph N. Yong
Department of Chemistry, University of Buea, Buea, Cameroon
Majoumo-Mbe Felicite
Department of Chemistry, University of Buea, Buea, Cameroon
Moses Samje
Department of Biomedical Sciences, University of Bamenda, Bambili, Cameroon
Emmanuel N. Nfor
Department of Chemistry, University of Buea, Buea, Cameroon

Abstract


The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.

Keywords


Hydralazine Hydrochloride, Schiff Bases, Anti-Onchocercal Activity.