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Synthesis, Molecular Structure and Anti-Onchocercal Studies of 1-(Phthalazin-1(2h)-One) [(pyridin-2-Yl)ethylidene]hydrazone
The novel ligand, 1-(phthalazin-1(2H)-one)[(pyridin-2-yl)ethylidene]hydrazone,(APN), derived from the antihypertensive drug, hydralazine hydrochloride, was synthesized and characterized by spectroscopic methods (IR, 1H NMR). The X-ray crystallographic data indicates that APN has an exocyclic C=N bond on the hydralazine moiety. APN revealed significant anti-onchocercal activity with IC50 values of 0.3125 μg/mL on microfilaria and 10 μg/mL on adult worms compared to the standard drug, ivermectin.
Hydralazine Hydrochloride, Schiff Bases, Anti-Onchocercal Activity.
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