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Synthesis, Spectroscopy and X-Ray Characterization, of Novel Derivatives of Substituted 2-(Benzothiazol-2'-Ylthio) Acetohydrazide


Affiliations
1 Department of Chemistry, Kuwait University, Safat, Kuwait
 

Treatment of 2-(benzo[d]thiazol-2'-ylthio)acetohydrazide (3) with acetylacetone afforded N-(4- oxopentan-2-ylidine) acetohydrazide derivative 5. The acetohyrazide derivatives 3 and 5 were utilized as a key intermediate for the synthesis of a novel heterocyclic compounds. The synthesis of a novel series of condensation and substituted derivatives of 2-(benzo[d]thiazol-2'-ylthio) acetohydrazide in good yield has been reported. The newly synthesized compounds were characterized by elemental analysis 1H-NMR, 13C-NMR spectra and X-ray crystallographic investigations. The reported crystal structures of these novel 2-(benzo[d] thiazol-2'-ylthio)acetohydrazide derivatives are expected to be a remarkable contribution to the crystallographic database of heterocyclic compounds.

Keywords

Acetohydrazide, Benzothiazole, Pyrazole, 1,2,4-Triazolopyridine, N’-Acetylcinnamohydrazide.
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  • Synthesis, Spectroscopy and X-Ray Characterization, of Novel Derivatives of Substituted 2-(Benzothiazol-2'-Ylthio) Acetohydrazide

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Authors

Al-Omran Fatima
Department of Chemistry, Kuwait University, Safat, Kuwait
El-Khair Adel Abou
Department of Chemistry, Kuwait University, Safat, Kuwait

Abstract


Treatment of 2-(benzo[d]thiazol-2'-ylthio)acetohydrazide (3) with acetylacetone afforded N-(4- oxopentan-2-ylidine) acetohydrazide derivative 5. The acetohyrazide derivatives 3 and 5 were utilized as a key intermediate for the synthesis of a novel heterocyclic compounds. The synthesis of a novel series of condensation and substituted derivatives of 2-(benzo[d]thiazol-2'-ylthio) acetohydrazide in good yield has been reported. The newly synthesized compounds were characterized by elemental analysis 1H-NMR, 13C-NMR spectra and X-ray crystallographic investigations. The reported crystal structures of these novel 2-(benzo[d] thiazol-2'-ylthio)acetohydrazide derivatives are expected to be a remarkable contribution to the crystallographic database of heterocyclic compounds.

Keywords


Acetohydrazide, Benzothiazole, Pyrazole, 1,2,4-Triazolopyridine, N’-Acetylcinnamohydrazide.