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Study on Gender Specific Variability of Gastrointestinal, Genitourinary and Depression Related Non Motor Symptoms of Parkinson Disease
Introduction: Parkinson’s disease is a second most common neurodegenerative disorder after Alzheimer’s disease. It affects 1% of population over age of 50 years. Three main features of PD is asymmetric onset of bradykinesia, rigidity and resting tremors. Non motor symptoms are common in patients of Parkinson’s Disease. These remain undiagnosed most of the time. Aim and Objectives: To analyse gender specific, age related and demographic variability of non motor symptoms (Gastrointestinal, genitourinary and depression related symptoms) of Parkinson’s disease. Material and Methods: Present study Included 100 cases (65 Males and 35 Females) of Parkinson’s disease presenting at department of neurology, Dayanand Medical College and hospital, Ludhiana. 30 questionnaire of non motor symptoms in hindi and Punjabi were given to patients. Gender, age, duration of non motor symptoms, Parkinson’s phenotype and complete demographic profile of each patient taken into account for study. Thereafter results were statistically analysed for all parameters. Conclusion: It is concluded that mean age and duration of non-motor symptoms were higher in males as compared to females. GI symptoms amongst non-motor symptoms were commonest and amongst GI symptoms constipation was most common and there was positive correlation of H&Y with age and non motor symptoms especially gastrointestinal, genitourinary and depression related symptoms.
Gender Specific Variability, Non Motor Symptoms of Parkinson, Parkinson’s Disease.
- Przedborski S. Etiology and pathogenesis of Parkinson’s disease. Jankovic J, Tolosa E, editors. Parkinson’s disease and Movement Disorder. 5th ed. Philadelphia: Lippincott Williams and wilkins; 2007. p. 77-92.
- The metric properties of a novel non motor symptoms scale of Parkinson’s disease: results from an international pilot study. Mov Disord. 2007; 22:1901–11. https://doi.org/10.1002/mds.21596 PMid:17674410
- Delong MR, Juncos JL. Parkinson’s disease and other extrapyramidal movement disorders. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jamesson JL, et al., editors. Harrison’s Principles of Internal Medicine. 17th ed. Newyork (NY): The McGraw-Hill Companies; 2008. p. 2549–59.
- Jankovic J, Shannon KM. Movement disorders. Bradley WG, Daroff RB, Fenichel GM editors. Neurology in Clinical Practice. 5th ed. Philadelphia: Butterworth- Heinemann, Elsevier; 2008. p. 2081–122.
- Chaudhuri KR, Healy DG, Schapira AHV. Nonmotor symptoms of parkinson’s disease: Diagnosis and management. Lancet Neurol. 2008; 5:314–24.
- Parkinson J. An essay on the shaking palsy. London: Sherwood, Neely and Jones; 1817.
- Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non recognition of depression and other non motor symptoms in parkinson’s disease. Parkinsonism Relat Discord. 2002; 8:193–7. https://doi.org/10.1016/S1353-8020(01)00015-3
- Tolosa E, Compta Y, Gaig C. The premotor phase of parkinson’s disease. Parkinsonism Relat Disord. 2007; 13(suppl):S2–7. https://doi.org/10.1016/j.parkreldis.2007.06.007 PMid:17681839
- Chaudhury KR, Healy DG, Schapira AH. Non-motor symptoms of Parkinson’s disease: Diagnosis and management. Lancet Neurol. 2006; 5:235–45. https://doi.org/10.1016/S1474-4422(06)70373-8
- Lolekha P, Kongkiat K. Non motor symptoms in Thai Parkinson disease patients: prevalence, manifestation and health related quality of life. Neurology Asia. 2014; 19(2):163–70.
- Ravan A, Faiz MR, Chabria S, Gadhari M, Sankhla CS. Nonmotor symptoms in an Indian cohort of Parkinson’s disease patients and correlation of progression of non motor symptoms with motor worsening. Neurology India. 2015; 63:166–74. https://doi.org/10.4103/0028-3886.156276 PMid:25947979
- Song Y, Gu Z, An J. Chinese Parkinson study group. Gender difference on motor and non motor symptoms of de novo patients with early Parkinson’s disease. Neurosci. 2014; 35:1991–6. https://doi.org/10.1007/s10072-014-1879-1
- Goetz CG, Lutze W, Tanner CM. Autonomic dysfunction in Parkinson’s disease. Neurology. 1986; 36–73.
- Krishnan S, Sarma G, Sarma S, Kishore A. Do non motor symptoms in Parkinson’s disease differ from normal aging. Mov Disord. 2011; 26:2110–3. https://doi.org/10.1002/mds.23826 PMid:21661056
- Ozge A, Bugdayy R, Togrol E, Saracoglu M. Gastrointestinal symptom in Parkinson disease. 14th International Congress on Parkinson Disease in Helsinki-Finland.
- Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. PRIAMO study group. The PRIAMO study: A multicenter assessment of non motor symptoms and their impact on quality of life in parkinson’s disease. Movdiscord 2009; 24:1641–9. https://doi.org/10.1002/mds.22643
- Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non recognition of depression and other non motor symptoms in Parkinson’s disease. Parkinsonism Relat Discord. 2002; 8:193–7. https://doi.org/10.1016/S1353-8020(01)00015-3
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