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Drug Delivery Through Blood Brain Barrier:Taming the Bottleneck in CNS Therapeutics


Affiliations
1 Department of Pharmacology, Government Medical College, Patiala, Punjab - 147001, India
 

Although many agents have therapeutic potentials for Central Nervous System (CNS) diseases, few of these agents have been clinically used because of the brain barriers. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. Different strategies for efficient CNS delivery have been studied. This review presents the current approaches to facilitate penetration across these barriers for enhanced drug delivery to the CNS.

Keywords

Blood Brain Barrier, CNS Drug Delivery.
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  • Drug Delivery Through Blood Brain Barrier:Taming the Bottleneck in CNS Therapeutics

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Authors

Vijay K. Sehgal
Department of Pharmacology, Government Medical College, Patiala, Punjab - 147001, India
Ritika Singla
Department of Pharmacology, Government Medical College, Patiala, Punjab - 147001, India

Abstract


Although many agents have therapeutic potentials for Central Nervous System (CNS) diseases, few of these agents have been clinically used because of the brain barriers. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. Different strategies for efficient CNS delivery have been studied. This review presents the current approaches to facilitate penetration across these barriers for enhanced drug delivery to the CNS.

Keywords


Blood Brain Barrier, CNS Drug Delivery.

References





DOI: https://doi.org/10.18311/ijmds%2F2018%2F20037