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Amitabh, Handique
- Value of AgNOR, in Malignant Lesions of Cervix
Authors
1 Department of Pathology, Tezpur Medical College, Tezpur, Assam, IN
Source
International Journal of Health Research and Medico Legal Practice, Vol 2, No 2 (2016), Pagination: 24-27Abstract
Objectives: To evaluate the correlation of AgNOR count and malignant lesions of cervix.
Methods: The material for the study was collected from patient with various lesions of cervix. After colposcopy, a cervical biopsy was done. Routine paraffin sectioning was done for these biopsy specimens. Histopathologic diagnosis was first established on these sections using the routine (H&E) stain. Then, further sections were cut from prepared blocks and were subjected to AgNOR staining technique. AgNOR count was taken as the mean number of black dots per 100 cells observed under a 100× oil immersion objective.
Results: In this series biopsy specimens were obtained and subjected to routine method of haematxoylin and eosin staining which revealed 25% to be benign and 26.6% to be cervical intraepithelial neoplasia and 48.4% cases to be carcinoma.
Conclusion: The results of the AgNOR when used can provide strength to the clinician and histopathologist in diagnosing early carcinoma in cases of suspicious cervix.