International Journal of Health Research and Medico Legal Practice

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Mercury Poisoning with Acute Kidney Injury


Affiliations
1 Dept. of Nephrology, Gauhati Medical College and Hospital, India
2 Gauhati Medical College and Hospital, Guwahati, Assam, India
 

Exposure to inorganic mercury or mercuric salt can occur as an occupational hazard or suicidal attempt and can cause vomiting, severe abdominal pain, gastrointestinal bleeding, hypovolemic shock and renal tubular necrosis leading to oliguria or anuria. Hemodialysis is used in severe cases of toxicity when renal function has declined. This report aims at highlighting the clinical presentation and course of a case of mercuric poisoning who was treated with hemodialysis. This article reports a case of mercury poisoning whose renal failure improved with high flux hemodialysis. A 25 years old girl ingested a heavy metal compound containing Mercuric chloride obtained from her place of work in a deliberate suicidal attempt, following which she developed massive hematemesis, hypotension and developed renal failure with anuria. She was treated with broad spectrum antibiotics, IV pantoprazole and high flux hemodialysis. Renal biopsy was suggestive of acute tubular necrosis. After 7 hemodialysis her urine output began to improve and dialysis was stopped. Her renal function gradually improved and her blood mercury level also decreased. We have here by presented a case of mercury intoxication with acute tubular necrosis in a 25-year old woman, with an excellent improvement of the renal failure and normalization of laboratory results with high flux hemodialysis.

Keywords

High Flux Dialysis, Renal Biopsy, Acute Tubular Necrosis.
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  • Barnes JL, McDowell EM, McNeil JS, Flamenbaum W, Trump BF. Studies on the pathophysiology of acute renal failure veffect of chronic saline loading on the progression of proximal tubular injury and functional impairment following administration of mercuric chloride in the rat. Virchows Arch B Cell Pathol InclMol Pathol 1980;32(3):233-60.

  • Norseth T, Clarkson TW.Intestinal transport of 203hg-labelled methyl mercury chloride role of biotransformation in rats. Archives of Environmental Health 1971;22(5):568–77.

  • Kostial K, Kello D, Jugo S, Rabar I, Maljkoviæ T. Influence of age on metal metabolism and toxicity. Environ Health Perspect 1978 Aug;25:81–6.

  • Taugner R, Winkel KZum, Iravani J. The localization of mercuric chloride concentration in the rat kidney. Virchows Archiv 1966;340(4):369–83.

  • Cherian MG, Clarkson TW. Radioactive mercury distribution in biological fluids and excretion in human subjects after inhalation of mercury vapour. Archives of Environmental Health 1978;33(3):109–14.

  • Berlin M, Ullberg S. Accumulation and retention of mercury in the mouse i an autoradiography study after a single intravenous injection of mercuric chloride. Archives of Environmental Health 1963;(6):589–601.

  • Bjornberg KA, Vahter M, Berglund B. Transport of methyl mercury and inorganic mercury to the fetus and breast-fed infant. Environ Health Perspect 2005;113:1381–5.

  • Dargan PI, Giles LJ, Wallace CI, House IM, Thomson AH, Beale RJ, et al. Severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration. Crit Care 2003;7:1–6.

  • Yoshida M, Satoh H, Igarashi M, Akashi K, Yamamura Y, Yoshida K. Acute mercury poisoning by intentional ingestion of mercuric chloride. Tohoku J ExpMed 1997;182:347–52.

  • Rothstein A, Hayes AD. The metabolism of mercury in the rat studied by isotope techniques. J PharmacolExpTher 1960;130:166.


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  • Mercury Poisoning with Acute Kidney Injury

Abstract Views: 433  |  PDF Views: 90

Authors

Manjuri Sharma
Dept. of Nephrology, Gauhati Medical College and Hospital, India
Arunima Mahanta
Dept. of Nephrology, Gauhati Medical College and Hospital, India
Himanab Jyoti Das
Dept. of Nephrology, Gauhati Medical College and Hospital, India
Baruah Swaroop Kumar
Gauhati Medical College and Hospital, Guwahati, Assam, India

Abstract


Exposure to inorganic mercury or mercuric salt can occur as an occupational hazard or suicidal attempt and can cause vomiting, severe abdominal pain, gastrointestinal bleeding, hypovolemic shock and renal tubular necrosis leading to oliguria or anuria. Hemodialysis is used in severe cases of toxicity when renal function has declined. This report aims at highlighting the clinical presentation and course of a case of mercuric poisoning who was treated with hemodialysis. This article reports a case of mercury poisoning whose renal failure improved with high flux hemodialysis. A 25 years old girl ingested a heavy metal compound containing Mercuric chloride obtained from her place of work in a deliberate suicidal attempt, following which she developed massive hematemesis, hypotension and developed renal failure with anuria. She was treated with broad spectrum antibiotics, IV pantoprazole and high flux hemodialysis. Renal biopsy was suggestive of acute tubular necrosis. After 7 hemodialysis her urine output began to improve and dialysis was stopped. Her renal function gradually improved and her blood mercury level also decreased. We have here by presented a case of mercury intoxication with acute tubular necrosis in a 25-year old woman, with an excellent improvement of the renal failure and normalization of laboratory results with high flux hemodialysis.

Keywords


High Flux Dialysis, Renal Biopsy, Acute Tubular Necrosis.

References