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A Study of Serum Zinc in Depression


Affiliations
1 Jorhat Medical College, Jorhat, Assam, India
2 Department of Biochemistry, Tezpur Medical College, Tezpur, Assam, India
3 Department of Psychiatry, Assam Medical College, Dibrugarh, Assam, India
4 Assam Medical College, Dibrugarh, Assam, India
 

Introduction: Depression, a mood disorder is a common mental health problem in all sections of people of the society, and it causes physical, psychological and social symptoms. So, keeping this in mind, the study is carried out to estimate serum zinc in cases of depression and compare the levels with that of age and sex matched healthy controls. Aim: To measure the serum zinc in clinically diagnosed patients with depression and study their levels in different age groups and gender. Methods: serum zinc estimation is done by colorimetric method. Serum albumin estimation is done by Bromocresol Green (BCG) method. Results: Serum zinc was significantly (p<0.01) lower in the cases (58.55±8.70 μμg/dl) than in the controls (64.78±9.86 μg/dl). Conclusion: It is suggestive that Serum zinc levels being lower in cases of depression; may have a role on the causation or be a result of depression. So, longer duration of study and with a larger sample size may reveal significant insights on the role of this micronutrient in depression.

Keywords

Psychiatry, Assam, Micronutrient.
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  • Reddy MS. Depression: The disorder and the burden. Indian J Psycho Med 2010 Jan-Jun;32(1):1-2.

  • Lecomte D, Fornes P. Suicide among youths and young adults,15 through 24 years of age. A report of 392 cases from Paris,1989-1996.J Forensic Sci43:946-68.

  • Song C, Lin A, Bonaccorso S, Heide C, Verkerk R, Kenis G et al. The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. J Affect Disorder 1998 Jun;49(3):211-9.

  • Maes M, Vandoolaeghe E, Neels H, Demedts P, Wauters A, Meltzer HY. Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biological Psychiatry 1997;42:349-58.

  • Kushner I. Regulation of the acute phase response by cytokines. Perspectives in Biology and Medicine 1993;36(4):611-22.

  • Nowak G, Szewczyk B, Pilc A. Zinc and depression.An update. Pharmacl. Rep 2005;57:713-18.

  • Makino T. A sensitive, direct colorimetric assay of serum zinc using nitro-PAPS and microwell plates.Clinica Chimica Acta 1991;197(3):209-20

  • Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem 1969;6:24–27.

  • Doumas BT, Watson WA, Biggs HG. Albumin standards and the measurement of serum albumin with bromcresol green. Clinica Chimica Acta 1971 Jan 1;31(1):87-96.

  • Siwek M, Szewczyk B, Dudek D, Styczeñ K, Sowa-Kuæma M, Mlyniec K et al. Zinc as amarker of affective disorders. Pharmacological Reports 2013;65:1512-18,ISSN 1734-140.

  • Salimi S, Kianpoor M, Abbasi MR, Abdani M, Moghaddam ES. Lower total serum protein, albumin and zinc in depression in an iranian population. J Med Sci 2008 Sep 15;8(6):587-90.

  • Mousavi SA, Habibbollahi H, Mahmoudian F. Low serum zinc level in depression. Journal of Research in Medical Sciences 2006; 11(3):190-92.

  • Amani R, Saeidi S, Nazari Z, Nematpour S. Correlation between dietary zinc intakes and its serum levels with depression scales in young female students. Biol Trace Elem Res 2010 Nov;137(2):150-8.

  • Maes M, DeVos N, Demedts P, Wauters A, Neels H. Lower serum zinc in major depression in relation to changes in serum acute phase proteins. Journal of Affective Disorders 1999 Dec;56(2-3):189–94.

  • Roozbeh J, Sharifian M, Ghanizadeh A, Sahraian A, Sagheb MM, Shabani S, et al. Association of zinc deficiency and depression in the patients with end-stage renal disease on hemodialysis. Journal of Renal Nutrition 2011 Mar;21(2):184-7.

  • Mc Loughlin IJ, Hodge JS. Zinc in depressive disorder. Acta Psychiatr Scand 1990 Dec;82(6):451-3.

  • Grieger JA, Nowson CA, Ackland LM. Nutritional and functional status indicators in residents of a long-term care facility. J Nutr Elder 2009;28:47–60.


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  • A Study of Serum Zinc in Depression

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Authors

Anju Teli Barhai
Jorhat Medical College, Jorhat, Assam, India
Jahnabi Baruah
Department of Biochemistry, Tezpur Medical College, Tezpur, Assam, India
Hiranya Goswami Kumar
Department of Psychiatry, Assam Medical College, Dibrugarh, Assam, India
Pratim Gupta
Assam Medical College, Dibrugarh, Assam, India

Abstract


Introduction: Depression, a mood disorder is a common mental health problem in all sections of people of the society, and it causes physical, psychological and social symptoms. So, keeping this in mind, the study is carried out to estimate serum zinc in cases of depression and compare the levels with that of age and sex matched healthy controls. Aim: To measure the serum zinc in clinically diagnosed patients with depression and study their levels in different age groups and gender. Methods: serum zinc estimation is done by colorimetric method. Serum albumin estimation is done by Bromocresol Green (BCG) method. Results: Serum zinc was significantly (p<0.01) lower in the cases (58.55±8.70 μμg/dl) than in the controls (64.78±9.86 μg/dl). Conclusion: It is suggestive that Serum zinc levels being lower in cases of depression; may have a role on the causation or be a result of depression. So, longer duration of study and with a larger sample size may reveal significant insights on the role of this micronutrient in depression.

Keywords


Psychiatry, Assam, Micronutrient.

References