Open Access Subscription Access
The Clinical Profile and Histological Variations of Medulloblastoma in North East India
Introduction: Medulloblastoma is the most common embryonal central nervous system (CNS) tumor of childhood. Medulloblastoma comprises up to 38% of all pediatric posterior fossa tumour. Objectives: To study the clinical presentation of medulloblastoma with regards to variables like age, sex, etc., the CT, MRI features and the various histological types, the modes of management and outcome of the patients belonging to the Northeast India. Method: This prospective study done in the Department of Neurosurgery Gauhati Medical College and Hospital from January 2010 to December 2016. A total of 65 patients were included in the study. Results: Most cases belonged to the paediatric age group with only 4.6% cases above 15 years. Male comprised 61.5% and female 38.4% with male to female ratio 1.6:1. Classical type was the most common with 51(78.4%) cases. Desmoplastic variant comprised 12(18.4%) cases and was seen in older age. Classical variants appeared as homogenous mass in CT scan while the desmoplastic and anaplastic variant appeared as heterogenous mass. Classical variants 49(75.3%) were mostly vermian in location. Heterogeneity is more common in the older age group and it is more prominent in MRI than CT. Gross total excision was done in 51(78.46%) cases and near total was done in 14(21.5%) cases. Recurrence was noted in 6 cases. Conclusion: Medulloblastoma is commonly seen in paediatric age and more common in males. Classical variant was the most common type with mostly vermian location. CT and MRI features varied in different variants of medulloblastoma. In most of the cases gross total excision was possible and surgical outcome is favorable.
Posterior Fossa Tumor, Childhood Tumour.
- Rutka JT. Medulloblastoma. Clin Neuro Surge 1997;44:571.
- Roberts RO, Lynch CF, Jones MP, Hart MN. Medulloblastoma: a population-based study of 532 cases. J Neuro Pathol Exp Neurol 1991;50:134-44.
- Duffner PK, Cohen ME. Recent developments in pediatric neurooncology. Cancer 1986;58:561-8.
- Bailey P, Cushing H. Medulloblastoma cerebelli: a common type of midcerebellar glioma of childhood. Arch Neurol & Psychiat 1925;XIV:192-223.
- Kadin ME, Rubinstein LJ, Nelson JS. Neonatal cerebellar medulloblastoma originating from the fetal external granular layer. J Neuropathol Exp Neurol 1970 Oct;29(4):583-600.
- Reddy AT, Packer RJ. Medulloblastoma. Curr Opin Neurol 1999 Dec;12(6):681-5.
- Marino S, Vooijs M, van Der GH, Jonkers J, Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 2000 Apr 15;14(8):994-1004.
- Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 2005 Jan;11(1):17-22.
- Raffle C. Medulloblastoma: molecular genetics and animal models. Neoplasia 2004 Jul;6(4):310-22.
- Schoenberg BS, Schoenberg DG, Christine BW, et al. The epidemiology of primary intracranial neoplasms of childhood. A population study. Mayo Clin Proc 1976;51:51.
- Agerlin N, Gjerris F, Brincker H. Childhood Medulloblastoma in Denmark 1960-1984. A population - based retrospective study. Childs Nerv Syst 1999;15:29.
- Alston RD, Newton R, Kelsey A, Newbould MJ. Developmental Medicine and Child Neurology. London: 2003 May ;45(5):308.
- McManamy CS, Pears J, Weston CL. Nodule formation and desmoplasia in medulloblastomas—defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol 2007;17:151.
- Bourgouin PM, Tampieri D, Grahovac SZ, Leger C, Del Carpio R, Melancon D. CT and MR imaging findings in adults with cerebellar medulloblastoma: comparison with findings in children. AJR Am J Roentgenol 1992;159:609-12.
- Hubbard JL, Scheithauer BW, Kispert DB, Carpenter SM, Wick MR, Laws ER, Jr. Adult cerebellar medulloblastomas: the pathologic, radiographic, and clinical disease spectrum. J Neurosurg 1989;70:536-44.
- Raffel C. Medulloblastoma: molecular genetics and animal models. Neoplasia 2004 Jul;6(4):310-22.
Abstract Views: 56
PDF Views: 0