Study of Incidence of Externally Visible Congenital Anomalies in Stillbirth Human Foetuses of Manipuri Origin
Introduction: Birth defect, congenital malformation, and congenital anomaly are synonymous term use to describe structural, behavioral, functional, and metabolic disorders present at birth. Causes of congenital anomalies are often divided into genetic and environmental factor. For 50-60% of congenital anomalies the etiology is unknown. In the present study, we only look for visible gross anomalies thereby the exact definition of congenital anomaly may not be fulfilled.
Materials and method: Study was conducted in the Department of Anatomy, Regional Institute of Medical Sciences, Imphal, for the period of 1 year, i.e., from 1st August 2011 to 1st August 2012. 120 numbers of stillbirth human foetuses were collected from the department of Obstetrics and Gynecology, RIMS, Imphal with a due permission from ethical committee. The specimens were preserved in 10% formalin. After 2 weeks specimens were observed carefully for any visible anomalies.
Results: Out of 120 foetuses; 15 foetuses, i.e., 12.5% were found to have congenital anomalies. The commonest anomaly is craniofacial anomaly (6.666%) in the form of anencephaly and cleft lip and palate. Next to craniofacial anomaly is vertebral arch defect in the form of spina bifida (2.5%). Other anomalies are abdominal wall defect and limbs defects, each contributing 1.666% of the total anomalies in the present study.
Conclusion: The incidence of congenital anomalies in the present study is 12.5%. The commonest anomaly encountered is in the form of craniofacial anomalies. This high of incidence congenital anomalies encountered in this study may be due to the fact that the study was conducted only in stillbirth human foetuses. Further research is recommended in order to pinpoint the causes of these of anomalies with the use of modern sophisticated tools.
- Sadler TW. Langman’s medical embryology. 11th ed. New Delhi: Wolters Kluwer Pvt. Ltd; 2011. p. 113.
- Moore KL, Persaud TVN. The developing human-clinically oriented embryology. 8th ed. New Delhi: Replika Press Pvt. Ltd; 2008. p. 457-8.
- Desilva M, Munoz FM, Mcmillan M, Kawai AT, Marshall H, Macartney et al. Congenital anomalies: case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 2016;34:6015-26.
- Rasmussen SA, Olney RS, Holmes LB, Lin AE, Keppler-Noreuil KM, Moore CA. Guidelines for case classification for the national birth defects prevention study. Birth Defects Res A Clinical Mol Teratol 2003;67:193-201.
- Gadow EC. Primary prevention of birth defects. In: Carrera JM, Carbero L, Baraibar R editors. Perinatal Medicine of the New Mellenium. Bologna: Monduzzi; 2001. p. 319-25.
- Al Jama F. Congenital malformations in newborns in a teaching hospital in eastern Saudi Arabia. J Obstet Gynaecol 2001;21:595-8.
- Gupta S, Gupta P, Soni JS. A study on incidence of various systemic congenital malformations and their association with maternal factors. National Journal of Medical Research 2012;2:19-21.
- Guha DK, Bhatia S. Mother based neonatal care unit. In: Guha DK editor. Neonatalogy: principles and practice. 2nd ed. New Delhi: Jaypee brothers; 2008. p. 65-66.
- Mishra PC, Baveja R. Congenital anomalies in a newborn - a prospective study. Indian Pediatrics 1989;26:53-58.
- Hatibaruah A, Hussain M. A study on prevalence of birth defects and its association with risk factors in fakhrudhin ali ahmed medical college and hospital. Journal of Evidence Based Medicine and Health care 2015;2(30):4336-43.
- Ghosh S, Bhargava SK, Bhatia R. Congenital anomalies in longitudinally studied birth cohort in a unban community. Indian J Med Res 1985;82:427-33.
- Shah K, Pensi CA. Study of incidence of congenital anomalies in newborns. Gujarat Medical Journal 2013;68(2):97-99.
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