Biometrics and Bioinformatics

T. Prem Anand ¹, C. Chellaram ¹

Affiliations
1 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

The discovery of novel chemical classes has been in decline for the past two decades, the need to exploit new resources in search for effective chemicals with novel mechanism of actions is imperative. Marine bacteria are such a resource yet to be tapped, and the potential it offers is vast. The antitumour assay (artemia toxicity bioassay) developed by McLaughlin et al. is being used as a "bench top bioassay" by many researchers for the preliminary screening of bioactive compounds. McLaughlin group has founded positive correlation between brine shrimp toxicity and cytotoxicity and has isolated a number of novel antitumor natural products using this bioassay. The lowest ED50 values were exhibited by 4 strains out of the 94 strains screened. Bacterial extracts exhibiting artemia toxicity test.

Keywords

Antitumor Activity, Marine Bacteria, Gulf of Mannar.

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G. Priya ¹, C. Chellaram ²

Affiliations
1 Department of Biotechnology, Dr. M.G.R. University, Chennai, Tamilnadu, IN
2 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

In the present investigation, an attempt has been made to test the hepatoprotective efficacy of the herbal plant Trianthema decandra on carbon tetrachloride induced toxic hepatitis. The carbon tetrachloride induced rats showed increased activity of Total protein, Total cholesterol, Triglycerides, ALP, AST, ALT and bilirubin in serum. The herbal Trianthema decandra leaf extract treated rats showed marked reduction in the activity of TP, TC, TG, ALP, AST, ALT &Bilirubin when compared with normal rats.

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D. Kesavan ¹, C. Chellaram ²

Affiliations
1 Department of Biotechnology, Vel Tech High Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN
2 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

On pharmacological study the leaf extract showed good anti-diarrhoeal profiles in two models. The ethanol extract showed significant anti diarrhoeal activity comparing to control group. The results obtained was comparable to the of the standard drug activity used. So from this investigation relating to different approaches it is observed that leaves of Bauhinia racemosa Lam contains some steroidal, glycosidal and flavanoidal components. The ethanol extract showed significant anti-diarrhoeal activity and anti-inflammatory activity from Bauhinia Racemosa Lam.

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C. Chellaram ¹, T. Prem Anand ¹

Affiliations
1 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

The bacteria isolated from the surface of the corals were found to have an inhibitory effect against 10 human pathogens. It was observed that out of 318 and 345 bacterial strains isolated from the surface of Favites abdita and Turbinaria mesenterina respectively, 12% was found be potent producers with maximum inhibition against Staphyloccus aureus (6 mm) and Streptococcus pneumonia (6 mm). It was observed in that the same percentage (12%) of bacterial strains isolated from Turbinaria mesenterina. Gram-positive, Gram-negative, pigmented and non-pigmented strains were all found to be antibiotic producers without exceptions. However, the antibiotic producing strains consisted of a higher percentage of non-pigmented strains in comparison with that of the pigmented ones, Favites abdita (38/288 strains), Turninaria mesenterina (41/304 strains). These results suggest that the epiphytic bacteria isolated from these corals could be effectively used for the development of novel drugs to combat the pathogens producing diseases to humans.

Keywords

Corals, Marine Bacteria, Antagonistic Activity, Human Pathogens.

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C. Gladis Rajamalar ¹, M. Chandrika ¹, C. Chellaram ²

Affiliations
1 Department of Chemistry, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN
2 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

The aim of the present investigation is to synthesis three different Schiff bases like 4-[-(4-hydroxy-3-methoxy benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazole-3-one,4–[(furan-2-yl-methylene-)-amino]-1,5–dimethyl-2-phenyl-1,2-dihydro-pyrazole-3-one, and 1,5-dimethyl-4 [(2-nitro benzylidene)-amino]-2-phenyl-1,2-dihydro-pyrazole-3-one. The above Schiff bases were characterized by IR,UV and NMR Spectral techniques.

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C. Chellaram ¹, N. Gurusamy ¹, T. Prem Anand ¹

Affiliations
1 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamilnadu, IN

Abstract

Apparatus and method for the early detection of somnolence of a person, particularly of a person gripping an object such as a steering wheel. A wrist band is worn by the person and sensors are pressed against the person's skin by band to sense various physiological parameters of the user, including peripheral pulse rate variability, peripheral vasodilation. If the majority of these parameters are indicative of increased somnolence, an audio alert is provided to the user. The main aim of this work is to provide an improved non-intrusive method for the physiological monitoring and alerting for events indicating increasing somnolence. A major advantage of this work is the absence of head-mounted electrodes and sensors. The monitoring from the limbs is a major advantage because the device is self-contained, having no wires to tangle with. The parameters monitored are analog signals in nature. They are amplified, filtered, and converted into a digital format for further processing by microcontroller or embedded unit. For each parameter an individualized baseline is computed and stored in memory. When the physiological value deviates from a preset baseline value an alert alarm is raised.

Keywords

Somnolence, Peripheral Pulse Rate, Vasodilation.

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