Biometrics and Bioinformatics

Archana Damodaran ¹, Balasubramanian Kabali ¹, Krishnan Muralikrishnan ¹, Sathya Palaniswamy ¹, Suresh Chander Kapali ²

Affiliations
1 Department of Physiology, Stanley Medical College, Chennai-1, IN
2 Department of Bio-Medical Engineering, Veltech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College in affiliated to Anna University, Chennai, IN

Abstract

Obesity, an evolving metabolic disease, has becomeone of the common risk factors for ailments like Hypertension, Diabetes Mellitus and Myocardial Infarction. Autonomic imbalance is one of the pathways to such increased morbidity and mortality. Heart Rate Variability (HRV) analysis is a non invasive research tool toassess the cardiovascular autonomic function. Although many methods are there to study the relationship between obesity and autonomic function, HRV plays an easy, simple, non invasive and effective method to study. We attempted to study the cardiovascular autonomic function in obese individuals using HRV as a measure of index. Heart Rate Variability analysis at supine rest in obese individuals were compared with age and gender matched non-obese ECG (Lead II) was acquired for 5 minutes at supine position with normal breath rate of 12-16/min and instantaneous RR intervals were analysed using Finland software for HRV. Both time and frequency domain measures were taken for analysis. Obese individuals found to have sympathovagal imbalance characterized by depressed para sympathetic tone and increased sympathetic activity.

Keywords

Body Mass Index, Heart Rate Variability, Obesity, Sympathovagal Balance.

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Samundeeswari Parameshwaran ¹, Balasubramanian Kabali ¹, Krishnan Muralikrishnan ¹, Suresh Chander Kapali ²

Affiliations
1 Department of Physiology, Stanley Medical College, Chennai-1, IN
2 Department of Bio-Medical Engineering, Veltech Multi Tech Dr. Rangarajan Dr. Sakunthala Engineering College in affiliated to Anna University, Chennai, IN

Abstract

Background: Systemic Lupus Erythematosus is a multi system disorder with auto immune origin. Autonomic dysfunction is attributed to morbidity of cardiovascular system in these patients. Heart rate variability is a useful tool in evaluating themodulations of autonomic nervous system. Aim of the study: To evaluate cardiac function in Systemic Lupus Erythematosus (SLE) patients by means of non invasive measures to detect earlydysfunction of cardiovascular system. Materials and methods: 30patients (28 female and 2 male) with SLE and 30 controls were enrolled for the study. This study evaluated the effects of Supine,Standing and Deep breathing on cardiac autonomic nervous modulation by heart rate variability. Both Time Domain andFrequency Domain measures were evaluated. Results were analysed using Student independent t test. Results: Subjects were similar with regard to height, weight, systolic and diastolic blood pressure. SDNN, RMSSD, and High Frequency(HF) component were decreased in SLE patients compared with healthy controls, but Low Frequency (LF) component, LF/HF and total power were higher in SLE patients. Conclusion: The results of our study showed that there is subclinical impairment of cardiovascular autonomic functions. HRV is a suitable technique to assess autonomic modulations in SLE patients.

Keywords

Heart Rate Variability, Systemic Lupus Erythematosus, Autonomic Nervous System, Polyrite.

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Gowri Velayutham ¹, Balasubramanian Kabali ¹

Affiliations
1 Stanley Medical College, Dr. MGR Medical University, Tamilnadu, IN

Abstract

Background: Hypothyroidism is a multi organ endocrine disorder also results in retro cochlear sensor neural hearing loss. Neuromuscular symptoms present in 30-80% of patients with hypothyroidism. BRAINSTEM EVOKED RESPONSE AUDIOMETRY (BERA) has expanded the possibility of objective testing of conduction in auditory pathway and hearing functions. Aim: To evaluate the audiological conduction i.e. electrical potential differences in auditory pathway recorded from the scalp in response to auditory stimuli as clicks. Objective: To use BERA as a tool to assess the hearing impairment of hypothyroid females. Materials and Methods: Study design was a cross sectional study. BERA recording was done in neurophysiology laboratory of Research wing, Department of Physiology, Stanley Medical College, using Polyrite Medicaid-Neuroperfect Plus. 30 hypothyroid females diagnosed from endocrine OPD and 30 normal healthy females were selected from Master Health Check Up. The left and right ears were tested separately in all subjects. Absolute Wave latencies I, II, III, IV and V, interpeak latency I-III, III-V and I-V and amplitudes of waves were measured. Statistical analysis was done by Student unpaired t test using SPSS software 11 version. There was significant prolongation of the inter peak latency of I-V in the study group compared to the control group and there was significant prolongation in the absolute latencies of the waveforms III and V which indicates thyroid hormone effects myelination of nerves. Hence hypothyroidism has leaded to demyelination caused by mitochondrial oxidative defects, decreased degradation of proteins. Conclusion: To conclude electrophysiological studies can be useful in the diagnosis of asymptomatic polyneuropathy in hypothyroid subjects. BERA can be a tool used to detect the neurological involvement earlier even before the subjects present clinically with complications of hypothyroidism. The other laboratory methods are highly improbable in diagnosing earlier involvement of nerves and muscles.

Keywords

Auditory Functions, Brainstem Evoked Response Audiometry, Hypothyroidism, Polyrite Medicaid-Neuro Perfect Plus.

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