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Nag, Shikha
- ESAT-6 Independent Survival and Virulence:Need For Paradigm Shift?
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1 National Centre for Cell Science, SPP University Campus, Ganeshkhind Road, Pune - 411 007, IN
1 National Centre for Cell Science, SPP University Campus, Ganeshkhind Road, Pune - 411 007, IN
Source
Current Science, Vol 115, No 4 (2018), Pagination: 669-676Abstract
Tuberculosis is a major health concern that has received lot of attention from researchers across the world. The virulent form of tuberculosis is caused by Mycobacterium tuberculosis (M. tb), a highly evolved, slow-growing, facultative pathogen. In the literature, the major suspected pathway responsible for its virulence is the Esx-1 secretion system owing to the properties attributed by ESAT-6 secretion. By arguing through literature instances that support ESAT-6 secretion independent virulence, this review not only questions ESAT-6 secretion as a sole readout to virulence, but also, suggests survivability as a likely separable property from virulence in mycobacterium, ultimately trying to create a tiny breach to the existing paradigm of thinking in mycobacterial pathogenesis in relation to ESAT-6 secretion.Keywords
ESAT-6 Secretion, Mycobacterium Tuberculosis, Virulence, Survivability.Full Text
References
- WHO, Global tuberculosis report 2016, WHO, 2017.
- Pym, A. S., Brodin, P., Brosch, R., Huerre, M. and Cole, S. T., Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol. Microbiol., 2002, 46, 709–717.
- Ganguly, N., Siddiqui, I. and Sharma, P., Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence. Tuberculosis, 2008, 88, 510–517.
- Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C. and Stover, C. K., Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J. Bacteriol., 1996, 178, 1274–1282.
- Pym, A. S. et al., Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat. Med., 2003, 9, 533– 539.
- Lewis, K. et al., Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette?Gu?rin Attenuation. J. Infect. Dis., 2003, 187, 117–123.
- Stoop, E. J. M., Bitter, W. and van der Sar, A. M., Tubercle bacilli rely on a type VII army for pathogenicity. Trends Microbiol., 2012, 20, 477–484.
- Gao, L.-Y., Guo, S., McLaughlin, B., Morisaki, H., Engel, J. N. and Brown, E. J., A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol. Microbiol., 2004, 53, 1677–1693.
- Sreejit, G. et al., The ESAT-6 protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (?2M) affecting antigen presentation function of macrophage. PLOS Pathog., 2014, 10, e1004446.
- Simeone, R., Bottai, D. and Brosch, R., ESX/type VII secretion systems and their role in host?pathogen interaction. Curr. Opin. Microbiol., 2009, 12, 4–10.
- Seghatoleslam, A. et al., Macrophage immune response suppression by recombinant Mycobacterium tuberculosis antigens, the ESAT-6, CFP-10, and ESAT-6/CFP-10 fusion proteins. Iran. J. Med. Sci., 2016, 41, 296–304.
- Pathak, S. K. et al., Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nat. Immunol., 2007, 8, 610–618.
- Hsu, T. et al., The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc. Natl. Acad. Sci. USA, 2003, 100, 12420–12425.
- Stanley, S. A., Raghavan, S., Hwang, W. W. and Cox, J. S., Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl. Acad. Sci. USA, 2003, 100, 13001–13006.
- Sherman, D. R., Guinn, K. M., Hickey, M. J., Mathur, S. K., Zakel, K. L. and Smith, S., Mycobacterium tuberculosis H37Rv: Delta RD1 is more virulent than M. bovis bacille Calmette-Guérin in long-term murine infection. J. Infect. Dis., 2004, 190, 123– 126.
- Bitter, W. et al., Systematic genetic nomenclature for type VII secretion systems. PLOS Pathog., 2009, 5, e1000507.
- Luthra, A., Mahmood, A., Arora, A. and Ramachandran, R., Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis. J. Biol. Chem., 2008, 283, 36532–36541.
- Ates, L. S. and Brosch, R., Discovery of the type VII ESX-1 secretion needle? Mol. Microbiol., 2017, 103, 7–12.
- Zhang, M., Chen, J. M., Sala, C., Rybniker, J., Dhar, N. and Cole, S. T., EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis. Mol. Microbiol., 2014, 93, 1057–1065.
- Behr, M. A. and Sherman, D. R., Mycobacterial virulence and specialized secretion: same story, different ending. Nat. Med., 2007, 13, 286–287.
- Solans, L. et al., A Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component. Infect. Immun., 2014, 82, 3446–3456.
- Blasco, B. et al., Virulence regulator EspR of mycobacterium tuberculosis is a nucleoid-associated protein. PLOS Pathog., 2012, 8, e1002621.
- Raghavan, S., Manzanillo, P., Chan, K., Dovey, C. and Cox, J. S., Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature, 2008, 454, 717–721.
- Cao, G. et al., EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the twocomponent systems MprAB and PhoPR. Microbiology, 2015, 161, 477–489.
- Garces, A. et al., EspA acts as a critical mediator of ESX1dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLOS Pathog., 2010, 6, e1000957.
- Chen, J. M. et al., Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence. J. Bacteriol., 2013, 195, 5421–5430.
- Korotkova, N. et al., Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. J. Struct. Biol., 2015, 191, 236–244.
- Ohol, Y. M., Goetz, D. H., Chan, K., Shiloh, M. U., Craik, C. S. and Cox, J. S., Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host Microbe, 2010, 7, 210–220.
- Chen, J. M. et al., Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence. Mol. Microbiol., 2013, 89, 1154–1166.
- McLaughlin, B. et al., A Mycobacterium ESX-1?Secreted virulence factor with unique requirements for export. PLOS Pathog., 2007, 3, e105.
- Anil Kumar, V. et al., EspR-dependent ESAT-6 protein secretion of Mycobacterium tuberculosis requires the presence of virulence regulator PhoP. J. Biol. Chem., 2016, 291, 19018–19030.
- Houben, D. et al., ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cell. Microbiol., 2012, 14, 1287–1298.
- Kennedy, G. M., Hooley, G. C., Champion, M. M., Mba Medie, F. and Champion, P. A. D., A novel ESX-1 locus reveals that surfaceassociated ESX-1 substrates mediate virulence in Mycobacterium marinum. J. Bacteriol., 2014, 196, 1877–1888.
- Fortune, S. M. et al., Mutually dependent secretion of proteins required for mycobacterial virulence. Poc. Natl. Acad. Sci. USA, 2005, 102, 10676–10681.
- Hunt, D. M. et al., Long-range transcriptional control of an Operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis. J. Bacteriol., 2012, 194, 2307–2320.
- Flint, J. L., Kowalski, J. C., Karnati, P. K. and Derbyshire, K. M., The RD1 virulence locus of Mycobacterium tuberculosis regulates DNA transfer in Mycobacterium smegmatis. Proc. Natl. Acad. Sci. USA, 2004, 101, 12598–12603.
- Converse, S. E. and Cox, J. S., A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J. Bacteriol., 2005, 187, 1238–1245.
- Woodworth, J. S., Fortune, S. M. and Behar, S. M., Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis Antigen CFP10. Infect. Immun., 2008, 76, 4199–4205.
- Frigui, W. et al., Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLOS Pathog., 2008, 4, e33.
- Brodin, P. et al., Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect. Immun., 2006, 74, 88–98.
- Bottai, D. et al., ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J. Infect. Dis., 2011, 203, 1155–1164.
- Broset, E., Mart?n, C. and Gonzalo-Asensio, J., Evolutionary landscape of the Mycobacterium tuberculosis complex from the viewpoint of PhoPR: implications for virulence regulation and application to vaccine development. MBio, 2015, 6, e01289-15.
- Kim, W. S. et al., Virulence-dependent alterations in the kinetics of immune cells during pulmonary infection by Mycobacterium tuberculosis. PLOS ONE, 2015, 10, e0145234.
- Repasy, T., Martinez, N., Lee, J., West, K., Li, W. and Kornfeld, H., Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis. Microbes Infect., 2015, 17, 564–574.