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Jaganathan, Saravana Kumar

Natural Frequency of Cancer Cells as a Starting Point in Cancer Treatment

Abstract Views :1217 | PDF Views:148

Authors

Saravana Kumar Jaganathan ¹, Aruna Priyadarshni Subramanian ¹, Muthu Vignesh Vellayappan ¹, Arunpandian Balaji ¹, Agnes Aruna John ¹, Ashok Kumar Jaganathan ², Eko Supriyanto ¹

Affiliations
1 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Research and Development Wing, AVTEC Ltd, CK Birla Group, Hosur 635 114, IN

Source

Current Science, Vol 110, No 9 (2016), Pagination: 1828-1832

Abstract

Breast cancer and prostate cancer are the most common gender-specific types of cancer among women and men respectively, around the world. The most preferred treatment embraced by the patients is chemotherapy. The anticancer drugs developed and used so far cannot completely cure cancer at all stages and also exhibit some side effects in the patients who undergo chemotherapy. Besides this, some cancer cells eventually acquire resistance to many drugs and evade the treatment procedures. All these factors play a vital role in persuading the researches to find alternative modes of treatment for cancer. This communication proposes an unconventional mode of cancer treatment by determining the natural frequencies of normal and cancer cells. By utilizing these frequencies, it is possible to kill the cancer cells specifically, sparing the healthy cells. The normal and cancer cells in case of breast (MCF-10A, MCF-7) as well as prostate cancer (BPH, LNCap) are modelled as a sphere in ANSYS. The modal analysis is done in order to obtain their natural frequencies along with their mode shapes at different frequencies. The results show that the natural frequency of the normal cells is much higher than that of the cancer cells at each corresponding mode. The natural frequency is proportional to the mechanical properties of the cells and is insignificant with respect to the change in diameter of the cells. Thus, utilizing the natural frequency, cancer cells may be specifically targeted while the burdens of chemotherapy and drug resistance.

Keywords

Breast Cancer, Modal Analysis, Natural Frequency, Prostate Cancer.

Full Text

References

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Jaganathan, S. K. et al., Estimation and comparison of natural frequency of coronary metallic stents using modal analysis. Indian J. Sci. Technol., 2015, 8(12), 1–7.

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Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

Abstract Views :246 | PDF Views:92

Authors

Agnes Aruna John ¹, Saravana Kumar Jaganathan ², Eko Supriyanto ³, A. Manikandan ⁴

Affiliations
1 Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 70000, VN
3 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
4 Department of Chemistry, Bharath Institute of Higher Education and Research, Bharath University, Chennai 600 073, IN

Source

Current Science, Vol 111, No 6 (2016), Pagination: 1003-1015

Abstract

Titanium (Ti) and Ti-based alloys are the best promising orthopaedic metal transplants. The Young's modulus of Ti and bone are nearer and so Ti implants are known as osseointegrated implants. However, the need for enhancing the osseointegration, corrosion resistance and biocompatibility cannot be ruled out in promoting the Ti as a golden standard. This review describes various surface modifications like acid etching, sand blasting, surface coating, alkali-heat treatment, plasma treatment and ion implantation of Ti-based implants which are the best solutions to promote biocompatibility, osseointegration and ultimately the longevity of implants. In addition, it gives an outline to accomplish the risky task in orthopaedics like recovering skeletal function by replacing the damaged bone for human being survival and it will assist the energetic collaboration of specialists in materials science, chemistry and biology for the quality enhancement.

Keywords

Corrosion Resistance, Osseointegration, Orthopaedics, Titanium and its Alloys, Surface Modification.

Full Text

An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer

Abstract Views :312 | PDF Views:85

Authors

Aruna Priyadharshni Subramanian ¹, Agnes Aruna John ¹, Muthu Vignesh Vellayappan ¹, Arunpandian Balaji ¹, Saravana Kumar Jaganathan ², A. Manikandan ³, Eko Supriyanto ⁴

Affiliations
1 Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, VN
3 Department of Chemistry, Bharath University, Chennai 600 073, IN
4 IJNU-TM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai 81300, Johor, MY

Source

Current Science, Vol 112, No 09 (2017), Pagination: 1839-1854

Abstract

Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.

Keywords

Anti-Cancer, Apoptosis, Breast Cancer, Honey, Phenolic.

Full Text

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Folic Acid Decorated Chitosan Nanoparticles and its Derivatives for the Delivery of Drugs and Genes to Cancer Cells

Abstract Views :340 | PDF Views:80

Authors

Agnes Aruna John ¹, Saravana Kumar Jaganathan ², Manikandan Ayyar ³, Navaneetha Pandiyaraj Krishnasamy ⁴, Rathanasamy Rajasekar ⁵, Eko Supriyanto ⁶

Affiliations
1 Universiti Teknologi Malaysia, Skudai 81310, Johor, MY
2 2Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, VN
3 Department of Chemistry, Bharath Institute of Higher Education and Research, Bharath University, Chennai 600 073, IN
4 Department of Physics, Sri Shakthi Institute of Engineering and Technology, Coimbatore 641 062, IN
5 Department of Mechanical Engineering, Kongu Engineering College, Erode-638 052, IN
6 IJN-UTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Universiti Teknologi Malaysia, Skudai 81300, Johor, MY

Source

Current Science, Vol 113, No 08 (2017), Pagination: 1530-1542

Abstract

Nanotechnology offers a number of nanoscale implements for medicine. Among these, nanoparticles are revolutionizing the field of drug and gene delivery. Chitosan is a natural polymer which provides a profitable tool to an innovative delivery system due to its inherent physicochemical and biological characteristics. Chitosan nanoparticles are promising drug and gene delivery carriers because of small size, better stability, low toxicity, inexpensiveness, simplicity, easy fabrication and versatile means of administration. Chitosan can also be easily modified chemically due to the presence of reactive functional hydroxide and amine groups. Folic acid is commonly engaged as a ligand, for targeting cancer cells, as its receptor, that transports folic acid into the cells through endocytosis and is over-expressed on the surface of several human epithelial cancer cells. Integrating folic acid into chitosan-based drug delivery inventions directs the systems with a well-organized targeting ability. The present review outlines several illustrations of this versatile system based on folate decorated chitosan, which have shown potential as auspicious delivery systems published over the past few years. In addition, it is probable to formulate chitosan nanocarriers that exhibit manifold usage beyond targeted delivery, such as nanotheranostics and cancer stem cell therapy.

Keywords

Cancer, Chitosan, Doxorubicin, Drug Delivery, Folic Acid, 5-fluorouracil, Gene Delivery.

Full Text

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