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Garg, Rakesh Kumar
- Extraction and Analysis of Ketamine (a Rave Drug) from Spiked Fruit Juices Using MEPS-MS for Forensic Purposes
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PDF Views:95
Authors
Affiliations
1 Department of Forensic Science, Punjabi University, Patiala 147 002, IN
2 Department of Pharmaceutical Sciences and Drugs Research, Punjabi University, Patiala 147 002, IN
1 Department of Forensic Science, Punjabi University, Patiala 147 002, IN
2 Department of Pharmaceutical Sciences and Drugs Research, Punjabi University, Patiala 147 002, IN
Source
Current Science, Vol 110, No 6 (2016), Pagination: 1059-1062Abstract
Micro extraction packed sorbent (MEPS) containing C8 and SCX (strong cation exchange) is employed to extract ketamine, a rave drug from fruit juices. The eluant was detected by mass spectral analysis wherein the drug was detected as a parent as well as some prominent fragment ions. The resultant MEPS-MS method proved very efficient and rapid. The mass spectrum of the eluant showed the parent ion peak (MH+) of ketamine at m/z 238 along with (MH2+) peak (30% of MH+) due to chlorine atom in the drug molecule. The daughter ions at m/z 220 and 207 were possible to be formed from the MH+ by loss of water and methylamine molecule respectively. Another daughter ion at m/z 179 was proposed to be formed by the loss of CO (28 mass units) from m/z 207 whereas m/z 125 was assigned to a chlorobenzyl cation. Based on the mode of fragmentation of drug to m/z 220 and 207 and their abundances, these ions can be used for quantitative analysis through selective reaction monitoring (SRM).Keywords
Date Rape, Extraction, Juices, Ketamine, Mass Spectrometry, MEPS.Full Text
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- Mephedrone - An Emerging Drug of Abuse in India
Abstract Views :312 |
PDF Views:84
Authors
Affiliations
1 Department of Forensic Science, Punjabi University, Patiala 147 002, IN
1 Department of Forensic Science, Punjabi University, Patiala 147 002, IN
Source
Current Science, Vol 112, No 11 (2017), Pagination: 2212-2218Abstract
Mephedrone (MEPH) is a synthetic derivative of cathinone, an alkaloid extracted from plant khat. Developed countries like UK, USA, Australia and Israel are the main places of MEPH abuse. Abuse of cathinone and MEPH in India has started recently. The young generation in metropolitan cities like Delhi, Mumbai, Ahmedabad and Panaji is being affected by its abuse. The increasing misuse of MEPH in India was due to its non-inclusion in the Narcotics Drugs and Psychotropic Substances (NDPS) Act, 1985 earlier. Due to the threat of MEPH abuse in the country, the Government of India included it in the NDPS Act from February 2015. Since then, the law enforcement agencies have taken strict action against MEPH users and traffickers.
In India, new drugs are rapidly emerging in the market and posing challenges for forensic toxicologists and law enforcement agencies. The seized drugs, urine and blood samples of the abusers are sent to forensic science laboratories for analysis. These samples are first screened by thin-layer chromatography, and then the confirmation and quantitation are done using modern instrumental methods. However, no studies are available in the literature on drug detection in saliva, sweat and other biological materials. Therefore a suitable technique needs to be developed for its detection in biological matrices. Particularly so for a country like India, this drug abuse is constantly increasing. In this article, we deal with the chemistry, pharmodynamics, drug-herb interaction, metabolic fate (pharmokinetics), related fatalities, abuse, effects and detection methods of MEPH, to create awareness about this drug abuse in India.
Keywords
Drug Abuse, Mephedrone, Synthetic Cathinone, Traffickers.Full Text
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