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Vellayappan, Muthu Vignesh
- Natural Frequency of Cancer Cells as a Starting Point in Cancer Treatment
Abstract Views :1211 |
PDF Views:145
Authors
Saravana Kumar Jaganathan
1,
Aruna Priyadarshni Subramanian
1,
Muthu Vignesh Vellayappan
1,
Arunpandian Balaji
1,
Agnes Aruna John
1,
Ashok Kumar Jaganathan
2,
Eko Supriyanto
1
Affiliations
1 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Research and Development Wing, AVTEC Ltd, CK Birla Group, Hosur 635 114, IN
1 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Research and Development Wing, AVTEC Ltd, CK Birla Group, Hosur 635 114, IN
Source
Current Science, Vol 110, No 9 (2016), Pagination: 1828-1832Abstract
Breast cancer and prostate cancer are the most common gender-specific types of cancer among women and men respectively, around the world. The most preferred treatment embraced by the patients is chemotherapy. The anticancer drugs developed and used so far cannot completely cure cancer at all stages and also exhibit some side effects in the patients who undergo chemotherapy. Besides this, some cancer cells eventually acquire resistance to many drugs and evade the treatment procedures. All these factors play a vital role in persuading the researches to find alternative modes of treatment for cancer. This communication proposes an unconventional mode of cancer treatment by determining the natural frequencies of normal and cancer cells. By utilizing these frequencies, it is possible to kill the cancer cells specifically, sparing the healthy cells. The normal and cancer cells in case of breast (MCF-10A, MCF-7) as well as prostate cancer (BPH, LNCap) are modelled as a sphere in ANSYS. The modal analysis is done in order to obtain their natural frequencies along with their mode shapes at different frequencies. The results show that the natural frequency of the normal cells is much higher than that of the cancer cells at each corresponding mode. The natural frequency is proportional to the mechanical properties of the cells and is insignificant with respect to the change in diameter of the cells. Thus, utilizing the natural frequency, cancer cells may be specifically targeted while the burdens of chemotherapy and drug resistance.Keywords
Breast Cancer, Modal Analysis, Natural Frequency, Prostate Cancer.Full Text
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- An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer
Abstract Views :312 |
PDF Views:85
Authors
Aruna Priyadharshni Subramanian
1,
Agnes Aruna John
1,
Muthu Vignesh Vellayappan
1,
Arunpandian Balaji
1,
Saravana Kumar Jaganathan
2,
A. Manikandan
3,
Eko Supriyanto
4
Affiliations
1 Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, VN
3 Department of Chemistry, Bharath University, Chennai 600 073, IN
4 IJNU-TM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai 81300, Johor, MY
1 Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, VN
3 Department of Chemistry, Bharath University, Chennai 600 073, IN
4 IJNU-TM Cardiovascular Engineering Center, Universiti Teknologi Malaysia, Skudai 81300, Johor, MY
Source
Current Science, Vol 112, No 09 (2017), Pagination: 1839-1854Abstract
Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.Keywords
Anti-Cancer, Apoptosis, Breast Cancer, Honey, Phenolic.Full Text
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