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Mandal, Amit Kumar
- Functional Prediction from Conformational Dynamics of Glycated and Glutathionylated HbE and HbD Punjab
Abstract Views :375 |
PDF Views:76
Authors
Sreekala Narayanan
1,
Boby Mathew
1,
Bindu Y. Srinivasu
1,
Monita Muralidharan
1,
Vijay Bhat
2,
Amit Kumar Mandal
1
Affiliations
1 Clinical Proteomics Unit, Division of Molecular Medicine, St John’s Research Institute, St John’s National Academy of Health Sciences, Bengaluru 560 034, IN
2 Manipal Hospital, Old Airport Road, Bengaluru 560 017, IN
1 Clinical Proteomics Unit, Division of Molecular Medicine, St John’s Research Institute, St John’s National Academy of Health Sciences, Bengaluru 560 034, IN
2 Manipal Hospital, Old Airport Road, Bengaluru 560 017, IN
Source
Current Science, Vol 118, No 5 (2020), Pagination: 722-727Abstract
Glycation and glutathionylation are important posttranslational modifications (PTMs) of human haemoglobin that act as biomarkers of diabetes mellitus and oxidative stress. These PTMs perturb the function of normal haemoglobin. However, the structure–function correlation of these PTMs of genetically modified haemoglobin remained unexplored. Using hydrogen/ deuterium exchange mass spectrometry, we studied the conformational dynamics of glycated and glutathionylated forms of two haemoglobin variants, HbE and HbD Punjab. Like glycated and glutathionylated normal haemoglobin, these PTMs of HbE were expected to have increased oxygen affinity. However, for HbD Punjab, glycation was predicted to have decreased oxygen affinity whereas glutathionylation to have increased oxygen affinity.Keywords
Glutathionylation, HbE, HbD Punjab, Glycation, Post-Translational Modifications, Structure–Function Correlation.Full Text
References
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- Coronaviruses and Tea Consumption: A Potential Strategy to Help Boost the Immune System
Abstract Views :267 |
PDF Views:70
Authors
Biswajit Bera
1,
Ahmet Kati
2,
Paulami Dam
3,
Amit Kumar Mandal
4,
Pritom Chowdhury
5,
Soumyananda Chakraborti
6,
Malay Kumar Saha
7,
Anil Bhuimali
8,
Octavio L. Franco
9
Affiliations
1 Quality Control Laboratory, Tea Board India, Ministry of Commerce and Industry, Siliguri 735 135, IN
2 Biotechnology Department, Institution of Health Sciences, University of Health Sciences Turkey, Istanbul, TR
3 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, Uttar Dinajpur 733 134, IN
4 Centre for Nanotechnology Sciences, Raiganj University, Uttar Dianjpur 733 134, IN
5 Department of Biotechnology, Tocklai Tea Research Institute, Tea Research Association, Jorhat 785 008, IN
6 Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, PL
7 Department of Virology, National Institute of Cholera and Enteric Diseases, Kolkata 700 010, IN
8 Raiganj University, Uttar Dianjpur 733 134, IN
9 Center of Proteomic and Biochemical Analysis, Post Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasilia, IN
1 Quality Control Laboratory, Tea Board India, Ministry of Commerce and Industry, Siliguri 735 135, IN
2 Biotechnology Department, Institution of Health Sciences, University of Health Sciences Turkey, Istanbul, TR
3 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, Uttar Dinajpur 733 134, IN
4 Centre for Nanotechnology Sciences, Raiganj University, Uttar Dianjpur 733 134, IN
5 Department of Biotechnology, Tocklai Tea Research Institute, Tea Research Association, Jorhat 785 008, IN
6 Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, PL
7 Department of Virology, National Institute of Cholera and Enteric Diseases, Kolkata 700 010, IN
8 Raiganj University, Uttar Dianjpur 733 134, IN
9 Center of Proteomic and Biochemical Analysis, Post Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Brasilia, IN
Source
Current Science, Vol 119, No 6 (2020), Pagination: 893-894Abstract
No Abstract.Keywords
No Keywords.Full Text
- Malaria epidemiology and its control during the COVID-19 pandemic situation in India
Abstract Views :128 |
PDF Views:63
Authors
Affiliations
1 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, North Dinajpur 733 134, India; Hematology Department, Nil Ratan Sircar Medical College and Hospital, Kolkata 700 014, India, IN
2 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, North Dinajpur 733 134, India, IN
1 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, North Dinajpur 733 134, India; Hematology Department, Nil Ratan Sircar Medical College and Hospital, Kolkata 700 014, India, IN
2 Chemical Biology Laboratory, Department of Sericulture, Raiganj University, North Dinajpur 733 134, India, IN
Source
Current Science, Vol 123, No 11 (2022), Pagination: 1299-1299Abstract
No Abstract.Full Text