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Jafari, Alireza
- Evaluating Risk Factors in Patients with Severe Asthma: A Cross-Sectional Study
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Authors
Ali Alavi Foumani
1,
Alireza Jafari
1,
Ehsan Kazem Nejad Leili
2,
Elnaz Daraie
1,
Negar Sheikhli
1,
Shima Ildari
1,
Reyhaneh Shabanian
1
Affiliations
1 Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, IR
2 Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, IR
1 Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, IR
2 Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, IR
Source
Current Science, Vol 118, No 7 (2020), Pagination: 1093-1098Abstract
Severe asthma (SA) is a major health problem which can be controlled with highdoses of inhaled or systemic glucocorticoids. In this cross-sectional study, 96 patients with SA attending a pulmonary clinic in Rasht, Iran were included. They were identified based on the American Thoracic Society and European Respiratory Society guidelines. Data were collected from spirometry results, asthma control test (ACT), and depression anxiety stressscales. Among these 96 patients with SA, 69 were women (71.9%) and 27 (28.1%) were men. Mean age of patients was 54.5 ± 12.4 years. There was a significant relationship between gender and ACT score (P= 0.03). However, there was no significant relationship between depression severity and ACT score (P> 0.00). This study showed a significant relationshipbetween anxiety and ACT score (P= 0.008). In addition, a significant relationship was seen between frequency of asthma exacerbation, stress, forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (P< 0.05). Thus there are many risk factors in our patients with SA including psychological disorders such as anxiety and depression which cause asthma exacerbations. The study also showed that increased sputum neutrophils are associated with asthma exacerbations.Keywords
Psychological Disorders, Pulmonary Function, Risk Factors, Severe Asthma.Full Text
References
- El-Sherbiny, I. M., El-Baz, N. M. and Yacoub, M. H., Inhaled nano- and microparticles for drug delivery. Global Cardiol. Sci. Pract., 2015, 2015(1), 2.
- Asher, I. and Pearce, N., Global burden of asthma among children. Int. J. Tuberculosis Lung Dis., 2014. 18(11), 1269–1278.
- To, T. et al., Is asthma a vanishing disease? A study to forecast the burden of asthma in 2022. BMC Public Health, 2013, 13(1), 254.
- Peters, S. P. et al., Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment. Respir. Med., 2006, 100(7), 1139–1151.
- Bateman, E. D. et al., Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J., 2008, 31(1), 143–178.
- Butler, C. and Heaney, L., Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur. Respir. J., 2006, 27(6), 1324– 1325.
- Taube, C., Difficult and severe asthma in adults: definition, diagnosis and treatment. Dtsch. Med. Wochenschr., 1946, 2012, 137(12), 585–591; doi:10.1055/s-0031-1298953.
- Jia, C. E. et al., The asthma control test and asthma control questionnaire for assessing asthma control: systematic review and meta-analysis. J. Allergy Clin. Immunol., 2013, 131(3), 695–703.
- Lavoie, K. L. et al., What is worse for asthma control and quality of life: depressive disorders, anxiety disorders, or both? Chest, 2006, 130(4), 1039–1047.
- Di Marco, F. et al., Close correlation between anxiety, depression, and asthma control. Res. Med., 2010, 104(1), 22–28.
- Kuehn, B. M., Asthma linked to psychiatric disorders. Jama, 2008, 299(2), 158–160.
- Chung, K. F. et al., International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur. Resp. J., 2014, 43(2), 343–373.
- Fazlollahi, M. R. et al., Paediatric asthma prevalence: the first national population-based survey in Iran. Clin Respir J., 2019, 13(1), 14–22.
- Ayuk, A. C., Ramjith, J. and Zar, H. J., Environmental risk factors for asthma in 13–14 year old African children. Pediatr. Pulmonol., 2018, 53(11), 1475–1484.
- Lai, C. K. et al., Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax, 2009, 64(6), 476–483.
- Melosini, L. et al., Asthma control test (ACT): comparison with clinical, functional, and biological markers of asthma control. J. Asthma, 2012, 49(3), 317–323.