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Brain-derived neurotrophic factor (BDNF) protects the retina from light-induced injury. In this study, white light suppressed the cell viability of 661W photoreceptor cells in a time- and intensity-dependent manner, decreased the mRNA and protein levels of ceramide kinase-like (CERKL), but increased the reactive oxygen species (ROS) content in 24 h. Decrease in ROS content and increase in CERKL level were detected after BDNF treatment. BDNF also attenuated the light-induced ROS accumulation, as well as cell viability and CERKL suppression. Thus, strong light causes CERKL suppression, ROS accumulation and the consequent attenuation of photoreceptor viability, while BDNF protects it from such injuries through upregulating CERKL expression and downregulating ROS accumulation.

Keywords

Brain-derived Neurotrophic Factor, Ceramide Kinase-like, Light-induced Injury, Photoreceptors, Reactive Oxygen Species.
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