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This issue of Annual Review of Nutrition (ARN) deals with many unusual nutrients as also with the complex interactions between nutrients. While the nutritional significance of fat-soluble vitamins is well-documented, most researchers tend to focus on the more popular areas, such as vitamin A and vision or vitamin D and bone health. Usually the other vitamins such as vitamin E and vitamin K get downplayed – and this issue of ARN attempts to bridge this gap. Shearer and Okano focus on vitamin K, which is classically known for its role in blood coagulation. The Vitamin K cycle involves its utilization as a cofactor for a microsomal enzyme, γ -carboxyglutamyl carboxylase (GGCX), and its subsequent regeneration by the enzyme Vit K epoxide reductase (VKOR).
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