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Comparative Study of 0.5% Bupivacaine and 0.5% Bupivacaine with Clonidine (50μg) for Spinal Anaesthesia
In present day, bupivacaine is the most commonly used drug for spinal anaesthesia. To improve upon the quality of analgesia and prolong the duration of its action, many adjuvants have been tried. Intrathecal clonidine an α2 adrenoceptor agonist has potent central antinociceptive properties with analgesic effect at spinal level mediated by post-synaptically situated adrenoreceptor in dorsal horn of spinal cord. Low doses of clonidine have shown effectiveness in intensifying spinal anaesthesia. This study was done to evaluate the efficacy of spinal anaesthesia with clonidine added to hyperbaric bupivacaine in lower abdominal surgeries.
Spinal Anesthesia, Clonidine, Bupivacaine, Complete and Effective Analgesia.
- Eisenach JC, et al. a2-adrenergic agonists for regional anaesthesia: a clinical review of clonidine (1984-1995). Anaesthesiology; 1996:85, 655-674.
- Niemi L. Effects of intrathecal clonidine on duration of bupivacaine spinal anaesthesia, haemodynamic, and postoperative analgesia in patients undergoing knee arthroscopy. Acta Anaestesiological Scandinavica 1994, 38: 724–728.
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