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Efficacy of Magnesium Sulphate in Attenuation of Succinylcholine Induced Fasciculations - A Dose Finding Study


Affiliations
1 VIMS, Ballari, India

Succinylcholine is still a drug of choice for general anaesthesia practice, rapid sequence intubation and in patients having predicted difficult airway. However, it is associated with undesirable effect like fasciculation with incidence being 94%. Magnesium competes with calcium at the neuromuscular junction and inhibits release of acetylcholine and has been shown to reduce incidence of fasciculations.

Keywords

Fasciculations, Magnesium Sulphate, Succinylcholine.
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  • Sakuraba S, Serita R, Kosugi S, et al. Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction. Acta Anaesthesiol Belg 2007;57(3):253-257
  • Mahendra Kumar, Nalin Talwar, Ritu Goyal, Usha Shukla, AK Sethi. Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia. Journal of Anaesthesiology Clinical Pharmacology. 2012; 28(1):81-85

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  • Efficacy of Magnesium Sulphate in Attenuation of Succinylcholine Induced Fasciculations - A Dose Finding Study

Abstract Views: 102  | 

Authors

Y. Vedashree
VIMS, Ballari, India
S. Balabhaskar
VIMS, Ballari, India
D. Srinivasalu
VIMS, Ballari, India
H. Balasubramanya
VIMS, Ballari, India

Abstract


Succinylcholine is still a drug of choice for general anaesthesia practice, rapid sequence intubation and in patients having predicted difficult airway. However, it is associated with undesirable effect like fasciculation with incidence being 94%. Magnesium competes with calcium at the neuromuscular junction and inhibits release of acetylcholine and has been shown to reduce incidence of fasciculations.

Keywords


Fasciculations, Magnesium Sulphate, Succinylcholine.

References





DOI: https://doi.org/10.18311/isacon-Karnataka%2F2017%2FFP040