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Comparative Study of Bupivacaine with Nalbuphine and Bupivacaine with Buprenorphine Intrathecally for Post-Operative Analgesia for Lower Limb and Lower Abdominal Surgeries-Prospective Randomised Study


Affiliations
1 AIMS, Mandya, Karnataka, India

Nalbuphine is an opioid, which is structurally related to oxymorphone, highly lipid soluble with an agonist activity at kappa and an antagonist activity at µ opioid receptor. Buprenorphine is also a highly lipid soluble thebaine derivative with a partial agonist activity at the μ-opioid receptor. Aim of the study was to compare the onset, duration of sensory blockade, duration of motor blockade, 2 segment regression and duration of post-operative analgesia achieved, by comparing hyperbaric bupivacaine with nalbuphine and hyperbaric bupivacaine with buprenorphine after intrathecal administration.

Keywords

Nalbuphine, Buprenorphine, Modified Bromage Scale, Sub-Arachnoid Block, Hyperbaric Bupivacaine.
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  • Veering B. Focus on Adjuvants in regional Anaesthesia. Euro Anesthesia 2005;28-31:217-21.
  • Morgan M. The rational use of intrathecal and extradural opioids. Br J Anaesth 1989;63: 165-88.

Abstract Views: 125




  • Comparative Study of Bupivacaine with Nalbuphine and Bupivacaine with Buprenorphine Intrathecally for Post-Operative Analgesia for Lower Limb and Lower Abdominal Surgeries-Prospective Randomised Study

Abstract Views: 125  | 

Authors

Upakara Selvin Rajan
AIMS, Mandya, Karnataka, India
R. Manjula
AIMS, Mandya, Karnataka, India

Abstract


Nalbuphine is an opioid, which is structurally related to oxymorphone, highly lipid soluble with an agonist activity at kappa and an antagonist activity at µ opioid receptor. Buprenorphine is also a highly lipid soluble thebaine derivative with a partial agonist activity at the μ-opioid receptor. Aim of the study was to compare the onset, duration of sensory blockade, duration of motor blockade, 2 segment regression and duration of post-operative analgesia achieved, by comparing hyperbaric bupivacaine with nalbuphine and hyperbaric bupivacaine with buprenorphine after intrathecal administration.

Keywords


Nalbuphine, Buprenorphine, Modified Bromage Scale, Sub-Arachnoid Block, Hyperbaric Bupivacaine.

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DOI: https://doi.org/10.18311/isacon-Karnataka%2F2017%2FFP026