Asian Journal of Research in Pharmaceutical Sciences

Ismail Hussain ¹, Ravikumar ², V. B. Narayanaswamy ³, Injamamul Haque ¹, Mohibul Hoque ⁴

Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
4 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN

Abstract

Transdermal drug delivery systems are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc. are intended to deliver a therapeutically effective amount of drug across the skin. In the present work, Transdermal drug delivery of Risperidone were formulated in different concentration (10%, 20% and 30% ) of glycerine and polyethylene glycol 400 as plasticizer and a blend of two in different concentrations of polymers (PVPK30,HPMC,PVA and Eudragit RS 100) were formulated by solvent casting method. Drug polymer interaction study was carried out using FTIR and DSC studies. In this study the results indicates, as increase in the concentration of glycerine and Polyethylene glycol increases the diffusion rate of Risperidone patches. The physico-chemical parameters like weight variation, thickness, folding endurance. Percentage Flatness and Water vapour transmission of the Risperidone patches were evaluated. All the physico chemical parameters were found to be satisfactory. Risperidone patches formulated by using 30% glycerine 30% PEG400shows enhanced rate of diffusion than the patches prepared with 10% and 20% glycerine10% and 20% PEG400 respectively. Risperidone patches formulated with 20% glycerine 20% PEG400 had enhanced rate than the patches prepared with 10%glycerine/10% PEG400 respectively. Among polymers, combination of HPMC and Eudragit had enhanced diffusion rate than the combination of HPMC and PVPK30 in all formulations formulated by using glycerine as plasticizer. The polymers, combination of PVPK30 and Eudragit had enhanced diffusion rate than the combination of PVPK30 and PVA in all formulations formulated by using PEG400 as plasticizer. The Risperidone transdermal patches shows greater diffusion rate when formulated with higher concentration of plasticizer hence the30% of glycerine and PEG 400 had shown a values higher than 20 and 10 % glycerine and PEG 400. The kinetic study and mechanism for the diffusion of Risperidone transdermal patches obeys higuchi, peppas model. The correlation coefficient (R2) values were greater, indicating from the analysis of diffusion data as per above models. The T50 and T80 values for Risperidone patches formulated with glycerine andPEG400 are exhibited good results. The SEM films indicating uniform distribution of the drug with polymers and plasticizers.

Keywords

Transdermal Drug Delivery, Diffusion Rate, Eudragit, Risperidone, Plasticizer, HPMC.

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V. P. Muhammed Jameel ¹, Ravikumar ², V. B. Narayanaswamy ³

Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN

Abstract

The objective of this research was to formulate fast dissolving tablets of Flecainide acetate that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Flecainide acetate is used for the treatment of cardiac arrhythmias and tachyarrhythmias. Fast dissolving tablets of Flecainide acetate were prepared by direct compression method using various superdisintegrants and by using sublimation method. Thirty two formulations were prepared by using different superdisintegrants and subliming agents and evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation S4 were found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation S4 containing Crospovidone as superdisintegrant and camphor as subliming agent were found to be the optimized combinations. Stability studies were carried out at 25°C±2°C/60%±5% RH and 40°C±2°C/75%±5% RH for formulation S4 for 90 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.

Keywords

Fast Dissolving Tablets, Flecainide Acetate, Superdisintegrant, Direct Compression, Sodium Starch Glycollate, Camphor, Crosspovidone.

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