Asian Journal of Research in Pharmaceutical Sciences

Sushil D. Patil ¹, Ashish Kumar Sharma ¹

Affiliations
1 Department of Pharmaceutical Chemistry, NIMS University, Shobha Nagar, Delhi Highway, Jaipur-303121 (Rajasthan), IN

Abstract

This compound we synthesize by a Knoevenagel condensation of 4-aminobenzaldehyde with compound (I) in presence of sodium acetate, but this compound do not comply with the primary aromatic amine test like nitrous acid test and carbylamine test as well as H¹ NMR spectra, in this reaction the amine group of benzaldehyde was further reacted another molecules of aldehydes. We modified the process and synthesized compound (Ia), the nitro group of compound Ia was converted in amino group by reduction.

Keywords

Thiazolidinedione, Benzaledhyde, Schiff Base.

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Sushil D. Patil ¹, Prajkta Varpe ², Sayali Chaure ², Siddharth B. Bhalerao ², Sanjay Kshirsagar ²

Affiliations
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, IN
2 Savitribai Phule Pune University, Pune, Maharshtra state, IN

Abstract

A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron) RP-18 column with a mobile phase consisting of Methanol: Water (20:80v/v) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.

Keywords

RP-HPLC, Force Degradation Study, Piracetam.

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