Asian Journal of Research in Pharmaceutical Sciences

Lankesh P. Shewale ¹, Sheetal B. Gondkar ¹, Ravindra B. Saudagar ², Avinash B. Dareker ¹

Affiliations
1 Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

The objective of this study was to design matrix tablets for oral sustained release of clopidogrel bisulfate and to investigate the sustained release behavior of the matrix tablets. Matrices were prepared by direct compression technique, melt method and microencapsulation using sodium carboxymethylcellulose, carnuba wax and ethyl cellulose as a release retardant. The FT-IR analysis indicated the stability and compatibility of drug with excipients. The formulation was optimized on the basis of acceptable tablet properties and invitro drug release. The resulting formulations produced tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies indicated that formulations F2 batch exhibited good drug release pattern to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from F2 formulation was sustained upto 12 hrs. Tablet Fitting in-vitro drug release data from optimized matrix formulation to Korsmeyer Pappas model equation indicated that diffusion and erosion could be mechanism of drug release. Matrix tablet F2 showed no change in physical appearance, drug content after storage 40°C, 75% RH for 3 months.

Keywords

Matrix Tablet, Release Retardant, Diffusion, Clopidogrel Bisulfate.

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Nikhil P. Mahalpure ¹, Sheetal B. Gondkar ¹, Ravindra B. Saudagar ²

Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

Conventional oral drug delivery systems supply continues release of drug, which cannot release of the drug and effective concentration at the target site. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic devices are the most promising technique for controlled drug delivery. Osmotic drug delivery system is one among the controlled drug delivery employed orally and also as an implantable devices. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi leeper pump, Higuchi Theeuwes pump, Elementary Osmotic pump etc. various techniques available for preparation of Osmotic Drug Delivery System include Push pull osmotic pump, Osmotic bursting osmotic pump, Liquid oral osmotic system, Sandwiched osmotic tablets, monolithic osmotic system and Controlled porosity osmotic pump. The present review is concerned with the study of drug release system which are tablets coated with walls of controlled porosity. When these system are exposed to water, low levels of water soluble additives is leached from polymeric material i.e. semi permeable membrane and drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In this paper, various type of osmotically controlled drug delivery systems and mainly the basic components and evaluation parameter of controlled porosity osmotic pump tablets have been discussed briefly.

Keywords

Osmotic Pump, Controlled-Porosity Osmotic Pump Tablet, Semi Permeable Membrane, Osmogent, Leachable Pore Formers.

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