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Khandbahale, Sarika V.
- Review on Resealed Erythrocyte
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1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
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Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 261-268Abstract
Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. Such drug-loaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, these carriers are called resealed erythrocytes. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Leucocytes, platelets, erythrocytes, nano erythrocytes, hepatocytes, and fibroblast etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.Keywords
Resealed Erythrocytes, Drug Targeting, Isolation, Drug Loading Method, Characterization Methods and Applications.- In-Situ Nasal Gel-A Review
Abstract Views :186 |
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Authors
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1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 1 (2017), Pagination: 23-32Abstract
Over the few decades, advances in the in-situ gel technologies have spurred development in many medical and biomedical applications including controlled drug delivery. Many Novel In-Situ gel based delivery matrices have been designed and fabricated to fulfill the ever increasing needs of the pharmaceutical and medical fields. In-Situ gel drug delivery systems are sol form before administration in the body, but once administered, undergo gelation in-situ, to form gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. In-Situ gels exhibit the properties of linear polymer solutions outside the body (allowing easy injection) but gel In-Situ within the body, providing prolonged drug release profiles. Recently, it has been shown that many drugs have better bioavailability by nasal route than the oral route. This has been attributed to reach vasculature and highly permeable structure of nasal mucosa coupled with avoidance of Hepatic-first pass metabolism. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.Keywords
Nasal In-Situ Gel, Absorption Enhancer, Nasal Formulation, Mucoadhesive Drug Delivery System.- Nanoparticle- A Review
Abstract Views :154 |
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Authors
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1 Department of Quality Assurance Technique, R. G. Sapkal college of Pharmacy, Anjaneri Nashik, IN
2 Depatment of Pharmaceutical chemistry, R.G. Sapkal college of Pharmacy Anjaneri, Nashik, IN
1 Department of Quality Assurance Technique, R. G. Sapkal college of Pharmacy, Anjaneri Nashik, IN
2 Depatment of Pharmaceutical chemistry, R.G. Sapkal college of Pharmacy Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 3 (2017), Pagination: 162-172Abstract
Nanotechnology refers to the creation and utilization of materials whose constituents exist at the nanoscale; and, by convention, be up to 100 nm in size. Nanotechnology explores electrical, optical, and magnetic activity as well as structural behaviour at the molecular and submolecular level. It has the potential to revolutionize a series of medical and biotechnology tools and procedures so that they are portable, cheaper, safer, and easier to administer. Nanoparticles are being used for diverse purposes, from medical treatments, using in various branches of industry production such as solar and oxide fuel batteries for energy storage, to wide incorporation into diverse materials of everyday use such as cosmetics or clothes, optical devices, catalytic, bactericidal, electronic, sensor technology, biological labelling and treatment of some cancers. Due to their exceptional properties including antibacterial activity, high resistance to oxidation and high thermal conductivity, nanoparticles have attracted considerable attention in recent years. Nanoparticles can be synthesized chemically or biologically. Metallic nanoparticles that have immense applications in industries are of different types, namely, Gold, Silver, Alloy, magnetic etc. This study aims to present an overview of nanoparticles, with special reference to their mechanism of biosynthesis and types.Keywords
Nanoparticles, Silver, Bactericidal, Thermal Conductivity, Optical Devices.References
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