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Patil, Sandeep B.
- Determination of LC50 Values of Extracts of Euphorbia nerifolia Linn Using Brine Shrimp Lethality Assay
Authors
1 Appasaheb Birnale college of Pharmacy, South Shivaji nagar, Sangli 416 416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 3 (2011), Pagination: 69-70Abstract
Brine shrimp lethality assay is an important tool for preliminary assessment of cytotoxicity of herbal drugs. This method is used for the determination of LC50 values of herbal extracts. In this study, extract of Euphorbia hirta Linn and Euphorbia nerifolia Linn, which are reported in traditional literature for their anti-tumour activity, had been selected to test for brine shrimp lethality activity. This experimentation shows that the LC50 of ethyl acetate and acetone extract of Euphorbia hirta Linn and methanolic extract Euphorbia nerifolia Linn are found to be 71.15, 92.15 and 49.55ug/ml respectively.Keywords
Brine shrimp lethality assay, Euphorbia hirta Linn, Euphorbia nerifolia Linn.
- Determination of LC50 Values of Extracts of Euphorbia hirta Linn and Euphorbia neriifolia Linn Using Brine Shrimp Lethality Assay
Authors
1 Appasaheb Birnale college of Pharmacy, South Shivaji nagar, Sangli 416 416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 2 (2011), Pagination: 42-43Abstract
Brine shrimp lethality assay is an important tool for preliminary assessment of cytotoxicity of herbal drugs. This method is used for the determination of LC50 values of herbal extracts. In this study, extract of Euphorbia hirta Linn and Euphorbia nerifolia Linn, which are reported in traditional literature for their anti-tumour activity, had been selected to test for brine shrimp lethality activity. This experimentation shows that the LC50 of ethyl acetate and acetone extract of Euphorbia hirta Linn and methanolic extract Euphorbia neriifolia Linn are found to be 71.15, 92.15 and 49.55ug/ml respectively.Keywords
Brine shrimp lethality assay, Euphorbia hirta Linn, Euphorbia neriifolia Linn.- Centrally Acting Analgesic Activity and CNS Depressant Activity of Cajanus cajan Linn
Authors
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli, IN
2 Department of Pharmaceutical chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
3 Department of Botany, Dr. Patangrao Kadam Mahavidyalya, Sangli, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 2 (2011), Pagination: 50-51Abstract
Cajanus cajan Linn which is synonymous to cajanus indicus is given different names like Red Gram. Pigeon Pea, Congo Pea and "Tur" by the local people of India.
The plant is an erect shrub which grows height of 1.5 to 3 meters with many branches. The leaves are pinnately trifoliate and the leaflets are oblong-lanceolate and entire.
The analgesic potency of aqueous extract of the leaves of Cajanus cajan Linn.and CNS depressant activity was investigated using animal model. Result showed that aq. extract of Cajanus cajan Linn. increased pain threshold in mice using hot plate methods and CNS depressant activity in mice by using actophotometer model. It is concluded that the Aqueous extract of Cajanus cajan Linn. can demonstrate strong analgesic and CNS depressant potency comparable in a times and dose dependant manner to a non steroidal anti-inflammatory drugs and benzodiazepines drug respectively.